Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity
Recent studies have linked changes in peripheral chemokine concentrations to the presence of both addictive behaviors and psychiatric disorders. The present study further explore this link by analyzing the potential association of psychiatry comorbidity with alterations in the concentrations of circ...
| Autores: | , , , , , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2017 |
| País: | España |
| Recursos: | Universitat Pompeu Fabra |
| Repositorio: | Repositorio Digital de la UPF |
| OAI Identifier: | oai:repositori.upf.edu:10230/33617 |
| Acesso em linha: | http://hdl.handle.net/10230/33617 http://dx.doi.org/10.3389/fpsyt.2016.00214 |
| Access Level: | acceso abierto |
| Palavra-chave: | Alcoholisme -- Tractament PRISM Alcohol use disorder Chemokine Eotaxin Outpatient setting Psychiatric comorbidity Sex |
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| dc.title.none.fl_str_mv |
Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity |
| title |
Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity |
| spellingShingle |
Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity García-Marchena, Nuria Alcoholisme -- Tractament PRISM Alcohol use disorder Chemokine Eotaxin Outpatient setting Psychiatric comorbidity Sex |
| title_short |
Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity |
| title_full |
Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity |
| title_fullStr |
Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity |
| title_full_unstemmed |
Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity |
| title_sort |
Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric Comorbidity |
| dc.creator.none.fl_str_mv |
García-Marchena, Nuria Araos, Pedro Barrios, Vicente Sánchez-Marín, Laura Chowen, Julie A. Pedraz, María Castilla Ortega, Estela Romero-Sanchiz, Pablo Ponce, Guillermo Gavito, Ana L. Decara, Juan M. Silva Peña, Daniel Torrens, Marta Argente, Jesús Rubio, Gabriel Serrano, Antonia Rodríguez de Fonseca, Fernando Pavón, Francisco Javier |
| author |
García-Marchena, Nuria |
| author_facet |
García-Marchena, Nuria Araos, Pedro Barrios, Vicente Sánchez-Marín, Laura Chowen, Julie A. Pedraz, María Castilla Ortega, Estela Romero-Sanchiz, Pablo Ponce, Guillermo Gavito, Ana L. Decara, Juan M. Silva Peña, Daniel Torrens, Marta Argente, Jesús Rubio, Gabriel Serrano, Antonia Rodríguez de Fonseca, Fernando Pavón, Francisco Javier |
| author_role |
author |
| author2 |
Araos, Pedro Barrios, Vicente Sánchez-Marín, Laura Chowen, Julie A. Pedraz, María Castilla Ortega, Estela Romero-Sanchiz, Pablo Ponce, Guillermo Gavito, Ana L. Decara, Juan M. Silva Peña, Daniel Torrens, Marta Argente, Jesús Rubio, Gabriel Serrano, Antonia Rodríguez de Fonseca, Fernando Pavón, Francisco Javier |
| author2_role |
author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
Alcoholisme -- Tractament PRISM Alcohol use disorder Chemokine Eotaxin Outpatient setting Psychiatric comorbidity Sex |
| topic |
Alcoholisme -- Tractament PRISM Alcohol use disorder Chemokine Eotaxin Outpatient setting Psychiatric comorbidity Sex |
| description |
Recent studies have linked changes in peripheral chemokine concentrations to the presence of both addictive behaviors and psychiatric disorders. The present study further explore this link by analyzing the potential association of psychiatry comorbidity with alterations in the concentrations of circulating plasma chemokine in patients of both sexes diagnosed with alcohol use disorders (AUD). To this end, 85 abstinent subjects with AUD from an outpatient setting and 55 healthy subjects were evaluated for substance and mental disorders. Plasma samples were obtained to quantify chemokine concentrations [C-C motif (CC), C-X-C motif (CXC), and C-X3-C motif (CX3C) chemokines]. Abstinent AUD patients displayed a high prevalence of comorbid mental disorders (72%) and other substance use disorders (45%). Plasma concentrations of chemokines CXCL12/stromal cell-derived factor-1 (p < 0.001) and CX3CL1/fractalkine (p < 0.05) were lower in AUD patients compared to controls, whereas CCL11/eotaxin-1 concentrations were strongly decreased in female AUD patients (p < 0.001). In the alcohol group, CXCL8 concentrations were increased in patients with liver and pancreas diseases and there was a significant correlation to aspartate transaminase (r = +0.456, p < 0.001) and gamma-glutamyltransferase (r = +0.647, p < 0.001). Focusing on comorbid psychiatric disorders, we distinguish between patients with additional mental disorders (N = 61) and other substance use disorders (N = 38). Only CCL11 concentrations were found to be altered in AUD patients diagnosed with mental disorders (p < 0.01) with a strong main effect of sex. Thus, patients with mood disorders (N = 42) and/or anxiety (N = 16) had lower CCL11 concentrations than non-comorbid patients being more evident in women. The alcohol-induced alterations in circulating chemokines were also explored in preclinical models of alcohol use with male Wistar rats. Rats exposed to repeated ethanol (3 g/kg, gavage) had lower CXCL12 (p < 0.01) concentrations and higher CCL11 concentrations (p < 0.001) relative to vehicle-treated rats. Additionally, the increased CCL11 concentrations in rats exposed to ethanol were enhanced by the prior exposure to restraint stress (p < 0.01). Concordantly, acute ethanol exposure induced changes in CXCL12, CX3CL1, and CCL11 in the same direction to repeated exposure. These results clearly indicate a contribution of specific chemokines to the phenotype of AUD and a strong effect of sex, revealing a link of CCL11 to alcohol and anxiety/stress. |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2018 2018 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
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http://hdl.handle.net/10230/33617 http://dx.doi.org/10.3389/fpsyt.2016.00214 |
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http://hdl.handle.net/10230/33617 http://dx.doi.org/10.3389/fpsyt.2016.00214 |
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Inglés |
| language_invalid_str_mv |
Inglés |
| dc.relation.none.fl_str_mv |
Frontiers in Psychiatry. 2017 Jan 18;7:214 |
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http://creativecommons.org/licenses/by/4.0/ info:eu-repo/semantics/openAccess |
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http://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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reponame:Repositorio Digital de la UPF instname:Universitat Pompeu Fabra |
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Universitat Pompeu Fabra |
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Plasma Chemokines in Patients with Alcohol Use Disorders: Association of CCL11 (Eotaxin-1) with Psychiatric ComorbidityGarcía-Marchena, NuriaAraos, PedroBarrios, VicenteSánchez-Marín, LauraChowen, Julie A.Pedraz, MaríaCastilla Ortega, EstelaRomero-Sanchiz, PabloPonce, GuillermoGavito, Ana L.Decara, Juan M.Silva Peña, DanielTorrens, MartaArgente, JesúsRubio, GabrielSerrano, AntoniaRodríguez de Fonseca, FernandoPavón, Francisco JavierAlcoholisme -- TractamentPRISMAlcohol use disorderChemokineEotaxinOutpatient settingPsychiatric comorbiditySexRecent studies have linked changes in peripheral chemokine concentrations to the presence of both addictive behaviors and psychiatric disorders. The present study further explore this link by analyzing the potential association of psychiatry comorbidity with alterations in the concentrations of circulating plasma chemokine in patients of both sexes diagnosed with alcohol use disorders (AUD). To this end, 85 abstinent subjects with AUD from an outpatient setting and 55 healthy subjects were evaluated for substance and mental disorders. Plasma samples were obtained to quantify chemokine concentrations [C-C motif (CC), C-X-C motif (CXC), and C-X3-C motif (CX3C) chemokines]. Abstinent AUD patients displayed a high prevalence of comorbid mental disorders (72%) and other substance use disorders (45%). Plasma concentrations of chemokines CXCL12/stromal cell-derived factor-1 (p < 0.001) and CX3CL1/fractalkine (p < 0.05) were lower in AUD patients compared to controls, whereas CCL11/eotaxin-1 concentrations were strongly decreased in female AUD patients (p < 0.001). In the alcohol group, CXCL8 concentrations were increased in patients with liver and pancreas diseases and there was a significant correlation to aspartate transaminase (r = +0.456, p < 0.001) and gamma-glutamyltransferase (r = +0.647, p < 0.001). Focusing on comorbid psychiatric disorders, we distinguish between patients with additional mental disorders (N = 61) and other substance use disorders (N = 38). Only CCL11 concentrations were found to be altered in AUD patients diagnosed with mental disorders (p < 0.01) with a strong main effect of sex. Thus, patients with mood disorders (N = 42) and/or anxiety (N = 16) had lower CCL11 concentrations than non-comorbid patients being more evident in women. The alcohol-induced alterations in circulating chemokines were also explored in preclinical models of alcohol use with male Wistar rats. Rats exposed to repeated ethanol (3 g/kg, gavage) had lower CXCL12 (p < 0.01) concentrations and higher CCL11 concentrations (p < 0.001) relative to vehicle-treated rats. Additionally, the increased CCL11 concentrations in rats exposed to ethanol were enhanced by the prior exposure to restraint stress (p < 0.01). Concordantly, acute ethanol exposure induced changes in CXCL12, CX3CL1, and CCL11 in the same direction to repeated exposure. These results clearly indicate a contribution of specific chemokines to the phenotype of AUD and a strong effect of sex, revealing a link of CCL11 to alcohol and anxiety/stress.Frontiers201820182017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/33617http://dx.doi.org/10.3389/fpsyt.2016.00214reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésFrontiers in Psychiatry. 2017 Jan 18;7:214Copyright © 2017 García-Marchena, Araos, Barrios, Sánchez-Marín, Chowen, Pedraz, Castilla-Ortega, Romero-Sanchiz, Ponce, Gavito, Decara, Silva, Torrens, Argente, Rubio, Serrano, de Fonseca and Pavón. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/336172026-06-12T07:21:37Z |
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