Development of a catheter-based technique for endoluminal radiofrequency sealing of pancreatic duct

[EN] Introduction: Endoluminal sealing of the pancreatic duct by glue or sutures facilitates the management of the pancreatic stump. Our objective was to develop a catheter-based alternative for endoluminal radiofrequency (RF) sealing of the pancreatic duct. Materials and methods: We devised a novel...

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Autores: Ewertowska, Elzbieta, Andaluz, Anna, Moll, Xavier, Adrià Aguilar, Garcia, Felix, Fondevila, Dolors, Quesada, Rita, Burdio, Fernando, Trujillo Guillen, Macarena|||0000-0003-4145-2188, Berjano, Enrique|||0000-0002-3247-2665
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/139356
Acceso en línea:https://riunet.upv.es/handle/10251/139356
Access Level:acceso abierto
Palabra clave:Ablation
Endoluminal
Pancreatic duct
Radiofrequency
Sealing
MATEMATICA APLICADA
TECNOLOGIA ELECTRONICA
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network_acronym_str ES
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repository_id_str
dc.title.none.fl_str_mv Development of a catheter-based technique for endoluminal radiofrequency sealing of pancreatic duct
title Development of a catheter-based technique for endoluminal radiofrequency sealing of pancreatic duct
spellingShingle Development of a catheter-based technique for endoluminal radiofrequency sealing of pancreatic duct
Ewertowska, Elzbieta
Ablation
Endoluminal
Pancreatic duct
Radiofrequency
Sealing
MATEMATICA APLICADA
TECNOLOGIA ELECTRONICA
title_short Development of a catheter-based technique for endoluminal radiofrequency sealing of pancreatic duct
title_full Development of a catheter-based technique for endoluminal radiofrequency sealing of pancreatic duct
title_fullStr Development of a catheter-based technique for endoluminal radiofrequency sealing of pancreatic duct
title_full_unstemmed Development of a catheter-based technique for endoluminal radiofrequency sealing of pancreatic duct
title_sort Development of a catheter-based technique for endoluminal radiofrequency sealing of pancreatic duct
dc.creator.none.fl_str_mv Ewertowska, Elzbieta
Andaluz, Anna
Moll, Xavier
Adrià Aguilar
Garcia, Felix
Fondevila, Dolors
Quesada, Rita
Burdio, Fernando
Trujillo Guillen, Macarena|||0000-0003-4145-2188
Berjano, Enrique|||0000-0002-3247-2665
author Ewertowska, Elzbieta
author_facet Ewertowska, Elzbieta
Andaluz, Anna
Moll, Xavier
Adrià Aguilar
Garcia, Felix
Fondevila, Dolors
Quesada, Rita
Burdio, Fernando
Trujillo Guillen, Macarena|||0000-0003-4145-2188
Berjano, Enrique|||0000-0002-3247-2665
author_role author
author2 Andaluz, Anna
Moll, Xavier
Adrià Aguilar
Garcia, Felix
Fondevila, Dolors
Quesada, Rita
Burdio, Fernando
Trujillo Guillen, Macarena|||0000-0003-4145-2188
Berjano, Enrique|||0000-0002-3247-2665
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Ingeniería Electrónica
Departamento de Matemática Aplicada
Escuela Técnica Superior de Ingeniería Aeroespacial y Diseño Industrial
Escuela Técnica Superior de Arquitectura
Biosignals & Minimally Invasive Technologies-BioMIT
Agencia Estatal de Investigación
Ministerio de Economía y Competitividad
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Ablation
Endoluminal
Pancreatic duct
Radiofrequency
Sealing
MATEMATICA APLICADA
TECNOLOGIA ELECTRONICA
topic Ablation
Endoluminal
Pancreatic duct
Radiofrequency
Sealing
MATEMATICA APLICADA
TECNOLOGIA ELECTRONICA
description [EN] Introduction: Endoluminal sealing of the pancreatic duct by glue or sutures facilitates the management of the pancreatic stump. Our objective was to develop a catheter-based alternative for endoluminal radiofrequency (RF) sealing of the pancreatic duct. Materials and methods: We devised a novel RF ablation technique based on impedance-guided catheter pullback. First, bench tests were performed on ex vivo models to tune up the technique before the in vivo study, after which endoluminal RF sealing of a similar to 10 cm non-transected pancreatic duct was conducted on porcine models using a 3 Fr catheter. After 30 days, sealing effectiveness was assessed by a permeability test and a histological analysis. Results: The RF technique was feasible in all cases and delivered similar to 5 W of power on an initial impedance of 308 +/- 60 ohm. Electrical impedance evolution was similar in all cases and provided guidance for modulating the pullback speed to avoid tissue sticking and achieve a continuous lesion. During the follow-up the animals rate of weight gain was significantly reduced (p < 0.05). Apart from signs of exocrine atrophy, no other postoperative complications were found. At necropsy, the permeability test failed and the catheter could not be reintroduced endoluminally, confirming that sealing had been successful. The histological analysis revealed a homogeneous exocrine atrophy along the ablated segment in all the animals. Conclusions: Catheter-based RF ablation could be used effectively and safely for endoluminal sealing of the pancreatic duct. The findings suggest that a fully continuous lesion may not be required to obtain complete exocrine atrophy.
publishDate 2019
dc.date.none.fl_str_mv 2019
2019-01-01
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/139356
url https://riunet.upv.es/handle/10251/139356
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 TEC2014-52383-C3-1-R TECNOLOGIAS BASADAS EN ENERGIA DE RADIOFRECUENCIA Y MICROONDAS PARA CIRUGIA DE MINIMA INVASION
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 BES-2015-073285 BES-2015-073285
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 RTI2018-094357-B-C21 MODELADO Y EXPERIMENTACION PARA TERAPIAS ABLATIVAS INNOVADORAS
Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 RTI2018-094357-B-C22 INVESTIGACION QUIRURGICA PARA TERAPIAS ABLATIVAS INNOVADORAS
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reconocimiento (by)
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Taylor & Francis
publisher.none.fl_str_mv Taylor & Francis
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411608067833856
spelling Development of a catheter-based technique for endoluminal radiofrequency sealing of pancreatic ductEwertowska, ElzbietaAndaluz, AnnaMoll, XavierAdrià AguilarGarcia, FelixFondevila, DolorsQuesada, RitaBurdio, FernandoTrujillo Guillen, Macarena|||0000-0003-4145-2188Berjano, Enrique|||0000-0002-3247-2665AblationEndoluminalPancreatic ductRadiofrequencySealingMATEMATICA APLICADATECNOLOGIA ELECTRONICA[EN] Introduction: Endoluminal sealing of the pancreatic duct by glue or sutures facilitates the management of the pancreatic stump. Our objective was to develop a catheter-based alternative for endoluminal radiofrequency (RF) sealing of the pancreatic duct. Materials and methods: We devised a novel RF ablation technique based on impedance-guided catheter pullback. First, bench tests were performed on ex vivo models to tune up the technique before the in vivo study, after which endoluminal RF sealing of a similar to 10 cm non-transected pancreatic duct was conducted on porcine models using a 3 Fr catheter. After 30 days, sealing effectiveness was assessed by a permeability test and a histological analysis. Results: The RF technique was feasible in all cases and delivered similar to 5 W of power on an initial impedance of 308 +/- 60 ohm. Electrical impedance evolution was similar in all cases and provided guidance for modulating the pullback speed to avoid tissue sticking and achieve a continuous lesion. During the follow-up the animals rate of weight gain was significantly reduced (p < 0.05). Apart from signs of exocrine atrophy, no other postoperative complications were found. At necropsy, the permeability test failed and the catheter could not be reintroduced endoluminally, confirming that sealing had been successful. The histological analysis revealed a homogeneous exocrine atrophy along the ablated segment in all the animals. Conclusions: Catheter-based RF ablation could be used effectively and safely for endoluminal sealing of the pancreatic duct. The findings suggest that a fully continuous lesion may not be required to obtain complete exocrine atrophy.This work was supported by the Spanish Ministerio de Economia, Industria y Competitividad under "Plan Estatal de Investigacion, Desarrollo e Innovacion Orientada a los Retos de la Sociedad" (Grant TEC2014-52383-C3-R) and by the Spanish Ministerio de Ciencia, Innovacion y Universidades under "Programa Estatal de I+D+i Orientada a los Retos de la Sociedad" (Grant: RTI2018-094357-B-C21 and -C22). Elzbieta Ewertowska has a Predoctoral Grant (BES-2015-073285) from the Ministry of Economy, Industry and Competitiveness (Government of Spain). Also funding was received from Secretaria de Estado de Investigacion, Desarrollo e Innovacion.Taylor & FrancisDepartamento de Ingeniería ElectrónicaDepartamento de Matemática AplicadaEscuela Técnica Superior de Ingeniería Aeroespacial y Diseño IndustrialEscuela Técnica Superior de ArquitecturaBiosignals & Minimally Invasive Technologies-BioMITAgencia Estatal de InvestigaciónMinisterio de Economía y CompetitividadRepositorio Institucional de la Universitat Politècnica de València Riunet20192019-01-01journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/139356reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 TEC2014-52383-C3-1-R TECNOLOGIAS BASADAS EN ENERGIA DE RADIOFRECUENCIA Y MICROONDAS PARA CIRUGIA DE MINIMA INVASIONMinisterio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 BES-2015-073285 BES-2015-073285Agencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 RTI2018-094357-B-C21 MODELADO Y EXPERIMENTACION PARA TERAPIAS ABLATIVAS INNOVADORASAgencia Estatal de Investigación http://dx.doi.org/10.13039/501100011033 Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020 RTI2018-094357-B-C22 INVESTIGACION QUIRURGICA PARA TERAPIAS ABLATIVAS INNOVADORASopen accesshttp://purl.org/coar/access_right/c_abf2Reconocimiento (by)http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/1393562026-06-13T07:49:27Z
score 15.300719

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