Acid digestion and symbiont: proton sharing at the origin of mitochondriogenesis?: proton production by a symbiotic bacterium may have been the origin of two hallmark eukaryotic features, acid digestion and mitochondria

The initial relationships between organisms leading to endosymbiosis and the first eukaryote are currently a topic of hot debate. Here, I present a theory that offers a gradual scenario in which the origins of phagocytosis and mitochondria are intertwined in such a way that the evolution of one woul...

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Detalles Bibliográficos
Autor: Mencía Caballero, Mario
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/705438
Acceso en línea:http://hdl.handle.net/10486/705438
https://dx.doi.org/10.1002/bies.202200136
Access Level:acceso abierto
Palabra clave:Acid digestion
Eukaryogenesis
Mitochondriogenesis
Phagocytosis
Proton gradient
Biología y Biomedicina / Biología
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spelling Acid digestion and symbiont: proton sharing at the origin of mitochondriogenesis?: proton production by a symbiotic bacterium may have been the origin of two hallmark eukaryotic features, acid digestion and mitochondriaMencía Caballero, MarioAcid digestionEukaryogenesisMitochondriogenesisPhagocytosisProton gradientBiología y Biomedicina / BiologíaThe initial relationships between organisms leading to endosymbiosis and the first eukaryote are currently a topic of hot debate. Here, I present a theory that offers a gradual scenario in which the origins of phagocytosis and mitochondria are intertwined in such a way that the evolution of one would not be possible without the other. In this scenario, the premitochondrial bacterial symbiont became initially associated with a protophagocytic host on the basis of cooperation to kill prey with symbiontproduced toxins and reactive oxygen species (ROS). Subsequently, the cooperation was focused on the digestion stage, through the acidification of the protophagocytic cavities via exportation of protons produced by the aerobic respiration of the symbiont. The host gained an improved phagocytic capacity and the symbiont received organic compounds from prey. As the host gradually lost its membrane energetics to develop lysosomal digestion, respiration was centralized in the premitochondrial symbiont for energy production for the consortiumWileyDepartamento de Biología MolecularFacultad de Ciencias20222022-11-14research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/705438https://dx.doi.org/10.1002/bies.202200136reponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/7054382026-06-23T12:46:27Z
dc.title.none.fl_str_mv Acid digestion and symbiont: proton sharing at the origin of mitochondriogenesis?: proton production by a symbiotic bacterium may have been the origin of two hallmark eukaryotic features, acid digestion and mitochondria
title Acid digestion and symbiont: proton sharing at the origin of mitochondriogenesis?: proton production by a symbiotic bacterium may have been the origin of two hallmark eukaryotic features, acid digestion and mitochondria
spellingShingle Acid digestion and symbiont: proton sharing at the origin of mitochondriogenesis?: proton production by a symbiotic bacterium may have been the origin of two hallmark eukaryotic features, acid digestion and mitochondria
Mencía Caballero, Mario
Acid digestion
Eukaryogenesis
Mitochondriogenesis
Phagocytosis
Proton gradient
Biología y Biomedicina / Biología
title_short Acid digestion and symbiont: proton sharing at the origin of mitochondriogenesis?: proton production by a symbiotic bacterium may have been the origin of two hallmark eukaryotic features, acid digestion and mitochondria
title_full Acid digestion and symbiont: proton sharing at the origin of mitochondriogenesis?: proton production by a symbiotic bacterium may have been the origin of two hallmark eukaryotic features, acid digestion and mitochondria
title_fullStr Acid digestion and symbiont: proton sharing at the origin of mitochondriogenesis?: proton production by a symbiotic bacterium may have been the origin of two hallmark eukaryotic features, acid digestion and mitochondria
title_full_unstemmed Acid digestion and symbiont: proton sharing at the origin of mitochondriogenesis?: proton production by a symbiotic bacterium may have been the origin of two hallmark eukaryotic features, acid digestion and mitochondria
title_sort Acid digestion and symbiont: proton sharing at the origin of mitochondriogenesis?: proton production by a symbiotic bacterium may have been the origin of two hallmark eukaryotic features, acid digestion and mitochondria
dc.creator.none.fl_str_mv Mencía Caballero, Mario
author Mencía Caballero, Mario
author_facet Mencía Caballero, Mario
author_role author
dc.contributor.none.fl_str_mv Departamento de Biología Molecular
Facultad de Ciencias
dc.subject.none.fl_str_mv Acid digestion
Eukaryogenesis
Mitochondriogenesis
Phagocytosis
Proton gradient
Biología y Biomedicina / Biología
topic Acid digestion
Eukaryogenesis
Mitochondriogenesis
Phagocytosis
Proton gradient
Biología y Biomedicina / Biología
description The initial relationships between organisms leading to endosymbiosis and the first eukaryote are currently a topic of hot debate. Here, I present a theory that offers a gradual scenario in which the origins of phagocytosis and mitochondria are intertwined in such a way that the evolution of one would not be possible without the other. In this scenario, the premitochondrial bacterial symbiont became initially associated with a protophagocytic host on the basis of cooperation to kill prey with symbiontproduced toxins and reactive oxygen species (ROS). Subsequently, the cooperation was focused on the digestion stage, through the acidification of the protophagocytic cavities via exportation of protons produced by the aerobic respiration of the symbiont. The host gained an improved phagocytic capacity and the symbiont received organic compounds from prey. As the host gradually lost its membrane energetics to develop lysosomal digestion, respiration was centralized in the premitochondrial symbiont for energy production for the consortium
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-11-14
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/705438
https://dx.doi.org/10.1002/bies.202200136
url http://hdl.handle.net/10486/705438
https://dx.doi.org/10.1002/bies.202200136
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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