Earth, a planetary PCR machine to create life, or the brief history of a tRNA

About 4 billion years ago, the Earth probably fulfilled the environmental conditions necessary to favour the transition from primitive chemistry to life. Based on a theoretical hairpin duplication origin of tRNAs and its putative peptide-coding capability before ribosomes existed, I postulate here t...

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Detalles Bibliográficos
Autor: Jiménez, Juan
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2025
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/421868
Acceso en línea:http://hdl.handle.net/10261/421868
Access Level:acceso abierto
Palabra clave:Earth-thermocycler
Nucleopeptide-reciprocal-replicator
Origin of life
Prebiotic chemistry
Proto tRNAs
RNA hairpins
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spelling Earth, a planetary PCR machine to create life, or the brief history of a tRNAJiménez, JuanEarth-thermocyclerNucleopeptide-reciprocal-replicatorOrigin of lifePrebiotic chemistryProto tRNAsRNA hairpinsAbout 4 billion years ago, the Earth probably fulfilled the environmental conditions necessary to favour the transition from primitive chemistry to life. Based on a theoretical hairpin duplication origin of tRNAs and its putative peptide-coding capability before ribosomes existed, I postulate here that, in this hypothetical environment, Earth's daily temperature cycles could have provided a unique planetary ‘PCR machine’ to create self-replicating RNA hairpins that simultaneously templated amino acid polymerization in a primordial ‘PCR well’ of prebiotic molecules. This early RNA hairpin-peptide interaction could have established a reciprocal nucleopeptide replicator that paved the way for catalytic translation and replication machineries towards the origin of LUCA.This work was supported by the Spanish Ministerio de Ciencia e Innovación (grant number PID2019-111124GB-I00). Funding for open access publishing: Universidad Pablo de Olavide/CBUA.Peer reviewedSpringerMinisterio de Ciencia, Innovación y Universidades (España)Agencia Estatal de Investigación (España)Universidad Pablo de OlavideConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202620262025info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/421868reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-111124GB-I00https://doi.org/10.1007/s11084-025-09691-8Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/4218682026-05-22T06:33:51Z
dc.title.none.fl_str_mv Earth, a planetary PCR machine to create life, or the brief history of a tRNA
title Earth, a planetary PCR machine to create life, or the brief history of a tRNA
spellingShingle Earth, a planetary PCR machine to create life, or the brief history of a tRNA
Jiménez, Juan
Earth-thermocycler
Nucleopeptide-reciprocal-replicator
Origin of life
Prebiotic chemistry
Proto tRNAs
RNA hairpins
title_short Earth, a planetary PCR machine to create life, or the brief history of a tRNA
title_full Earth, a planetary PCR machine to create life, or the brief history of a tRNA
title_fullStr Earth, a planetary PCR machine to create life, or the brief history of a tRNA
title_full_unstemmed Earth, a planetary PCR machine to create life, or the brief history of a tRNA
title_sort Earth, a planetary PCR machine to create life, or the brief history of a tRNA
dc.creator.none.fl_str_mv Jiménez, Juan
author Jiménez, Juan
author_facet Jiménez, Juan
author_role author
dc.contributor.none.fl_str_mv Ministerio de Ciencia, Innovación y Universidades (España)
Agencia Estatal de Investigación (España)
Universidad Pablo de Olavide
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Earth-thermocycler
Nucleopeptide-reciprocal-replicator
Origin of life
Prebiotic chemistry
Proto tRNAs
RNA hairpins
topic Earth-thermocycler
Nucleopeptide-reciprocal-replicator
Origin of life
Prebiotic chemistry
Proto tRNAs
RNA hairpins
description About 4 billion years ago, the Earth probably fulfilled the environmental conditions necessary to favour the transition from primitive chemistry to life. Based on a theoretical hairpin duplication origin of tRNAs and its putative peptide-coding capability before ribosomes existed, I postulate here that, in this hypothetical environment, Earth's daily temperature cycles could have provided a unique planetary ‘PCR machine’ to create self-replicating RNA hairpins that simultaneously templated amino acid polymerization in a primordial ‘PCR well’ of prebiotic molecules. This early RNA hairpin-peptide interaction could have established a reciprocal nucleopeptide replicator that paved the way for catalytic translation and replication machineries towards the origin of LUCA.
publishDate 2025
dc.date.none.fl_str_mv 2025
2026
2026
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/421868
url http://hdl.handle.net/10261/421868
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-111124GB-I00
https://doi.org/10.1007/s11084-025-09691-8
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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