Perampanel outcomes at different stages of treatment in people with focal and generalized epilepsy treated in clinical practice: Evidence from the PERMIT study

Effectiveness; Focal epilepsy; Perampanel

Detalles Bibliográficos
Autores: Liguori, Claudio, Santamarina Pérez, Estevo, Strzelczyk, Adam, Rodríguez-Uranga, Juan Jesús, Shankar, Rohit, Rodríguez Osorio, Xiana
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/9445
Acceso en línea:https://hdl.handle.net/11351/9445
Access Level:acceso abierto
Palabra clave:Epilèpsia - Tractament
Anticonvulsius - Ús terapèutic
Avaluació de resultats (Assistència sanitària)
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Epilepsy::Epilepsies, Partial
Other subheadings::Other subheadings::Other subheadings::/drug therapy
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Central Nervous System Agents::Anticonvulsants
Other subheadings::Other subheadings::/therapeutic use
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::epilepsia::epilepsias parciales
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::fármacos del sistema nervioso central::anticonvulsivantes
Otros calificadores::Otros calificadores::/uso terapéutico
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento
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oai_identifier_str oai:scientiasalut.gencat.cat:11351/9445
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Perampanel outcomes at different stages of treatment in people with focal and generalized epilepsy treated in clinical practice: Evidence from the PERMIT study
title Perampanel outcomes at different stages of treatment in people with focal and generalized epilepsy treated in clinical practice: Evidence from the PERMIT study
spellingShingle Perampanel outcomes at different stages of treatment in people with focal and generalized epilepsy treated in clinical practice: Evidence from the PERMIT study
Liguori, Claudio
Epilèpsia - Tractament
Anticonvulsius - Ús terapèutic
Avaluació de resultats (Assistència sanitària)
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Epilepsy::Epilepsies, Partial
Other subheadings::Other subheadings::Other subheadings::/drug therapy
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Central Nervous System Agents::Anticonvulsants
Other subheadings::Other subheadings::/therapeutic use
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::epilepsia::epilepsias parciales
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::fármacos del sistema nervioso central::anticonvulsivantes
Otros calificadores::Otros calificadores::/uso terapéutico
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento
title_short Perampanel outcomes at different stages of treatment in people with focal and generalized epilepsy treated in clinical practice: Evidence from the PERMIT study
title_full Perampanel outcomes at different stages of treatment in people with focal and generalized epilepsy treated in clinical practice: Evidence from the PERMIT study
title_fullStr Perampanel outcomes at different stages of treatment in people with focal and generalized epilepsy treated in clinical practice: Evidence from the PERMIT study
title_full_unstemmed Perampanel outcomes at different stages of treatment in people with focal and generalized epilepsy treated in clinical practice: Evidence from the PERMIT study
title_sort Perampanel outcomes at different stages of treatment in people with focal and generalized epilepsy treated in clinical practice: Evidence from the PERMIT study
dc.creator.none.fl_str_mv Liguori, Claudio
Santamarina Pérez, Estevo
Strzelczyk, Adam
Rodríguez-Uranga, Juan Jesús
Shankar, Rohit
Rodríguez Osorio, Xiana
author Liguori, Claudio
author_facet Liguori, Claudio
Santamarina Pérez, Estevo
Strzelczyk, Adam
Rodríguez-Uranga, Juan Jesús
Shankar, Rohit
Rodríguez Osorio, Xiana
author_role author
author2 Santamarina Pérez, Estevo
Strzelczyk, Adam
Rodríguez-Uranga, Juan Jesús
Shankar, Rohit
Rodríguez Osorio, Xiana
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Liguori C] Epilepsy Centre, Neurology Unit, University Hospital “Tor Vergata”, Rome, Italy. Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy. [Santamarina E] Servei de Neurologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Strzelczyk A] Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Goethe University, Frankfurt am Main, Germany. [Rodríguez-Uranga JJ] Centro de Neurología Avanzada, Sevilla, Spain. [Shankar R] Peninsula School of Medicine, Plymouth, United Kingdom. [Rodríguez-Osorio X] Department of Neurology, Complexo Hospitalario Universitario de Santiago, Santiago, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Epilèpsia - Tractament
Anticonvulsius - Ús terapèutic
Avaluació de resultats (Assistència sanitària)
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Epilepsy::Epilepsies, Partial
Other subheadings::Other subheadings::Other subheadings::/drug therapy
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Central Nervous System Agents::Anticonvulsants
Other subheadings::Other subheadings::/therapeutic use
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::epilepsia::epilepsias parciales
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::fármacos del sistema nervioso central::anticonvulsivantes
Otros calificadores::Otros calificadores::/uso terapéutico
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento
topic Epilèpsia - Tractament
Anticonvulsius - Ús terapèutic
Avaluació de resultats (Assistència sanitària)
DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Epilepsy::Epilepsies, Partial
Other subheadings::Other subheadings::Other subheadings::/drug therapy
CHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Central Nervous System Agents::Anticonvulsants
Other subheadings::Other subheadings::/therapeutic use
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment Outcome
ENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::epilepsia::epilepsias parciales
Otros calificadores::Otros calificadores::Otros calificadores::/farmacoterapia
COMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::fármacos del sistema nervioso central::anticonvulsivantes
Otros calificadores::Otros calificadores::/uso terapéutico
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamiento
description Effectiveness; Focal epilepsy; Perampanel
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/9445
url https://hdl.handle.net/11351/9445
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Frontiers in Neurology;14
https://doi.org/10.3389/fneur.2023.1120150
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411604727070720
spelling Perampanel outcomes at different stages of treatment in people with focal and generalized epilepsy treated in clinical practice: Evidence from the PERMIT studyLiguori, ClaudioSantamarina Pérez, EstevoStrzelczyk, AdamRodríguez-Uranga, Juan JesúsShankar, RohitRodríguez Osorio, XianaEpilèpsia - TractamentAnticonvulsius - Ús terapèuticAvaluació de resultats (Assistència sanitària)DISEASES::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Epilepsy::Epilepsies, PartialOther subheadings::Other subheadings::Other subheadings::/drug therapyCHEMICALS AND DRUGS::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Central Nervous System Agents::AnticonvulsantsOther subheadings::Other subheadings::/therapeutic useANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Diagnosis::Prognosis::Treatment OutcomeENFERMEDADES::enfermedades del sistema nervioso::enfermedades del sistema nervioso central::enfermedades cerebrales::epilepsia::epilepsias parcialesOtros calificadores::Otros calificadores::Otros calificadores::/farmacoterapiaCOMPUESTOS QUÍMICOS Y DROGAS::acciones y usos químicos::acciones farmacológicas::usos terapéuticos::fármacos del sistema nervioso central::anticonvulsivantesOtros calificadores::Otros calificadores::/uso terapéuticoTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::diagnóstico::pronóstico::resultado del tratamientoEffectiveness; Focal epilepsy; PerampanelEficacia; Epilepsia focal; PerampanelEfectivitat; Epilèpsia focal; PerampanelIntroduction: The PERMIT study is the largest pooled analysis of perampanel (PER) clinical practice data conducted to date. Methods: This post-hoc analysis of PERMIT investigated the effectiveness, safety and tolerability of PER when used as early add-on therapy (after failure of one or two previous antiseizure medications) in comparison with late add-on therapy (after failure of three or more previous antiseizure medications). Retention and effectiveness were assessed after 3, 6, and 12 months, and at the last visit (last observation carried forward). Effectiveness was assessed by seizure type (total seizures, focal seizures, generalized tonic-clonic seizures [GTCS]) and assessments included seizure freedom rate and responder rate. Safety and tolerability were assessed by evaluating adverse events (AEs) and discontinuation due to AEs. Results: The Full Analysis Set included 1184 and 2861 PWE treated with PER as early and late add-on therapy, respectively. Compared to the late add-on subgroup, the early add-on subgroup was characterized by later mean age at epilepsy onset, shorter mean duration of epilepsy, lower rates of intellectual disability and psychiatric comorbidity, and lower frequency of seizures per month, suggesting a less severe form of epilepsy in this subgroup. After 12 months, retention was significantly higher in the early versus late add-on subgroup (67.7% vs. 62.4%; p = 0.004). At the last visit, responder rates in the early versus late add-on subgroup were significantly higher for total seizures (68.2% vs. 39.3%; p < 0.001), focal seizures (65.0% vs. 36.8%; p < 0.001) and GTCS (83.7% vs. 67.2%; p < 0.001), as were seizure freedom rates (total seizures, 35.9% vs. 11.9% [p < 0.001]; focal seizures, 29.4% vs. 8.7% [p < 0.001]; GTCS, 69.0% vs. 48.1% [p < 0.001]). Incidence of AEs was significantly lower in the early versus late add-on subgroup (42.1% vs. 54.7%; p < 0.001), as was the rate of discontinuation due to AEs over 12 months (15.0% vs. 18.1%; p = 0.031). Discussion: This study demonstrated that PER was effective and generally well tolerated when initiated as early or late add-on therapy, but it was significantly more effective and better tolerated when initiated early. These findings support PER's use as a broad-spectrum, early add-on therapy for use in PWE with focal and generalized seizures.The study received funding from Eisai Ltd. Editorial assistance was provided by John Scopes of mXm Medical Communications and funded Eisai Ltd.Frontiers MediaInstitut Català de la Salut[Liguori C] Epilepsy Centre, Neurology Unit, University Hospital “Tor Vergata”, Rome, Italy. Department of Systems Medicine, University of Rome “Tor Vergata”, Rome, Italy. [Santamarina E] Servei de Neurologia, Vall d'Hebron Hospital Universitari, Barcelona, Spain. [Strzelczyk A] Epilepsy Center Frankfurt Rhine-Main, Department of Neurology, Goethe University, Frankfurt am Main, Germany. [Rodríguez-Uranga JJ] Centro de Neurología Avanzada, Sevilla, Spain. [Shankar R] Peninsula School of Medicine, Plymouth, United Kingdom. [Rodríguez-Osorio X] Department of Neurology, Complexo Hospitalario Universitario de Santiago, Santiago, SpainVall d'Hebron Barcelona Hospital Campus202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttps://hdl.handle.net/11351/9445Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésFrontiers in Neurology;14https://doi.org/10.3389/fneur.2023.1120150Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/94452026-06-12T09:38:37Z
score 15.811543

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