Bisphenol a exposure and kidney diseases
Bisphenol A (BPA) is a compound that is especially widespread in most commonly used objects due to its multiple uses in the plastic industry. However, several data support the need to restrict its use. In recent years, new implications of BPA on the renal system have been discovered, which denotes t...
| Autores: | , , , , , , |
|---|---|
| Tipo de recurso: | artículo |
| Fecha de publicación: | 2021 |
| País: | España |
| Institución: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:271889 |
| Acceso en línea: | https://ddd.uab.cat/record/271889 https://dx.doi.org/urn:doi:10.3390/biom11071046 |
| Access Level: | acceso abierto |
| Palabra clave: | Bisphenol A Kidney Systematic review Meta-analysis |
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Bisphenol a exposure and kidney diseasesSystematic review, meta-analysis and nhanes 03-16 studyMoreno-Gómez-toledano, R.Arenas, M.I.Vélez-Vélez, E.Coll, Elisabet|||0000-0003-0371-6250Quiroga, Borja|||0000-0001-5730-1929Bover, Jordi|||0000-0003-3577-2273Bosch, R.J.Bisphenol AKidneySystematic reviewMeta-analysisBisphenol A (BPA) is a compound that is especially widespread in most commonly used objects due to its multiple uses in the plastic industry. However, several data support the need to restrict its use. In recent years, new implications of BPA on the renal system have been discovered, which denotes the need to expand studies in patients. To this end, a systematic review and a meta-analysis was performed to explore existing literature that examines the BPA-kidney disease paradigm and to determine what and how future studies will need to be carried out. Our systematic review revealed that only few relevant publications have focused on the problem. However, the subsequent meta-analysis revealed that high blood concentrations of BPA could be a factor in developing kidney disease, at least in people with previous pathologies such as diabetes or hypertension. Furthermore, BPA could also represent a risk factor in healthy people whose urinary excretion is higher. Finally, the data analyzed from the NHANES 03-16 cohort provided new evidence on the possible involvement of BPA in kidney disease. Therefore, our results underline the need to carry out a thorough and methodologically homogeneous study, delving into the relationship between urinary and blood BPA, glomerular filtration rate, and urine albumin-to-creatinine ratio, preferably in population groups at risk, and subsequently in the general population, to solve this relevant conundrum with critical potential implications in Public Health.Universitat Autònoma de Barcelona 22021-01-0120212021-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/271889https://dx.doi.org/urn:doi:10.3390/biom11071046reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI15/02139open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2718892026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
Bisphenol a exposure and kidney diseases Systematic review, meta-analysis and nhanes 03-16 study |
| title |
Bisphenol a exposure and kidney diseases |
| spellingShingle |
Bisphenol a exposure and kidney diseases Moreno-Gómez-toledano, R. Bisphenol A Kidney Systematic review Meta-analysis |
| title_short |
Bisphenol a exposure and kidney diseases |
| title_full |
Bisphenol a exposure and kidney diseases |
| title_fullStr |
Bisphenol a exposure and kidney diseases |
| title_full_unstemmed |
Bisphenol a exposure and kidney diseases |
| title_sort |
Bisphenol a exposure and kidney diseases |
| dc.creator.none.fl_str_mv |
Moreno-Gómez-toledano, R. Arenas, M.I. Vélez-Vélez, E. Coll, Elisabet|||0000-0003-0371-6250 Quiroga, Borja|||0000-0001-5730-1929 Bover, Jordi|||0000-0003-3577-2273 Bosch, R.J. |
| author |
Moreno-Gómez-toledano, R. |
| author_facet |
Moreno-Gómez-toledano, R. Arenas, M.I. Vélez-Vélez, E. Coll, Elisabet|||0000-0003-0371-6250 Quiroga, Borja|||0000-0001-5730-1929 Bover, Jordi|||0000-0003-3577-2273 Bosch, R.J. |
| author_role |
author |
| author2 |
Arenas, M.I. Vélez-Vélez, E. Coll, Elisabet|||0000-0003-0371-6250 Quiroga, Borja|||0000-0001-5730-1929 Bover, Jordi|||0000-0003-3577-2273 Bosch, R.J. |
| author2_role |
author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Bisphenol A Kidney Systematic review Meta-analysis |
| topic |
Bisphenol A Kidney Systematic review Meta-analysis |
| description |
Bisphenol A (BPA) is a compound that is especially widespread in most commonly used objects due to its multiple uses in the plastic industry. However, several data support the need to restrict its use. In recent years, new implications of BPA on the renal system have been discovered, which denotes the need to expand studies in patients. To this end, a systematic review and a meta-analysis was performed to explore existing literature that examines the BPA-kidney disease paradigm and to determine what and how future studies will need to be carried out. Our systematic review revealed that only few relevant publications have focused on the problem. However, the subsequent meta-analysis revealed that high blood concentrations of BPA could be a factor in developing kidney disease, at least in people with previous pathologies such as diabetes or hypertension. Furthermore, BPA could also represent a risk factor in healthy people whose urinary excretion is higher. Finally, the data analyzed from the NHANES 03-16 cohort provided new evidence on the possible involvement of BPA in kidney disease. Therefore, our results underline the need to carry out a thorough and methodologically homogeneous study, delving into the relationship between urinary and blood BPA, glomerular filtration rate, and urine albumin-to-creatinine ratio, preferably in population groups at risk, and subsequently in the general population, to solve this relevant conundrum with critical potential implications in Public Health. |
| publishDate |
2021 |
| dc.date.none.fl_str_mv |
2 2021-01-01 2021 2021-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
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article |
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https://ddd.uab.cat/record/271889 https://dx.doi.org/urn:doi:10.3390/biom11071046 |
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https://ddd.uab.cat/record/271889 https://dx.doi.org/urn:doi:10.3390/biom11071046 |
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Inglés eng |
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Inglés |
| language |
eng |
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Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 PI15/02139 |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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