Genetic Differences in Reactivity to the Environment Impact Psychotic-Like and Affective Reactivity in Daily Life.
Background and Hypothesis: Consistent with diathesis-stress models, psychosis research has focused on geneticmoderation of adverse environmental exposures. In con-trast, the Differential Susceptibility (DS) model suggeststhat the same genetic variants that increase risk-inducingeffects of adverse ex...
| Autores: | , , , , , , |
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| Formato: | artículo |
| Estado: | Versión publicada |
| Fecha de publicación: | 2025 |
| País: | España |
| Recursos: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:dnet:ubarcelona__::86a78b7c8756f4027357be521f42fa5c |
| Acesso em linha: | https://hdl.handle.net/2445/228863 |
| Access Level: | acceso abierto |
| Palavra-chave: | Psicologia Genètica humana Trastorns afectius Psychology Human genetics Affective disorders |
| Resumo: | Background and Hypothesis: Consistent with diathesis-stress models, psychosis research has focused on geneticmoderation of adverse environmental exposures. In con-trast, the Differential Susceptibility (DS) model suggeststhat the same genetic variants that increase risk-inducingeffects of adverse experiences also enhance beneficial ef-fects from positive experiences. This study examinedwhether individuals with high genetic susceptibility to theenvironment showed differential psychotic-like and affec-tive reactivity in response to positive and negative events indaily life. Study Design: Experience sampling methodologyassessed context (positive and stressful) and momentarylevels of paranoia, psychotic-like experiences (PLE), andpositive (PA) and negative affect (NA) in 217 non-clinicaladults oversampled for schizotypy. Linear mixed modelsexamined whether Polygenic Risk Scores of EnvironmentalSensitivity (PRS-ES) moderated the impact of current con-text on subsequent experiences. Study Results: PRS-ESmoderated positive, but not stressful, context on subsequentlevels of momentary paranoia, NA, and PA, but not PLE.Genetic and environmental (G × E) interactions indicateddiathesis-stress at lower thresholds of PRS-ES, but a DSmodel at the highest threshold of the PRS-ES. Participantswith elevated PRS-ES showed increased paranoia and NAand decreased PA in subsequent assessments when re-porting low levels of positive situations, but also decreasedparanoia and NA and increased PA when rating contextsas positive. Conclusions: Findings support the influence ofgenetic sensitivity to the environment on psychotic-like andaffective reactivity in daily life, particularly in response topositive contexts. This highlights the transdiagnostic pro-tective role of positive experiences and informs ecologicalmomentary interventions. |
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