Working on genomic stability: From the S-phase to mitosis

[EN]Fidelity in chromosome duplication and segregation is indispensable for maintaining genomic stability and the perpetuation of life. Challenges to genome integrity jeopardize cell survival and are at the root of di erent types of pathologies, such as cancer. The following three main sources of ge...

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Autores: Ovejero, Sara, Bueno Núñez, Andrés Avelino, Sacristán Martín, María Paz
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2020
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/154794
Acceso en línea:http://hdl.handle.net/10366/154794
Access Level:acceso abierto
Palabra clave:Cell Cycle
DNA Replication
Replication Stress
Mitosis
Chromosome Instability
DNA Damage Response
2302 Bioquímica
2415 Biología Molecular
2407 Biología Celular
ciclo celular
id ES_7c481c2a24c738baf2c644cd699751d4
oai_identifier_str oai:gredos.usal.es:10366/154794
network_acronym_str ES
network_name_str España
repository_id_str
spelling Working on genomic stability: From the S-phase to mitosisOvejero, SaraBueno Núñez, Andrés AvelinoSacristán Martín, María PazCell CycleDNA ReplicationReplication StressMitosisChromosome InstabilityDNA Damage ResponseCell Cycle2302 Bioquímica2415 Biología Molecular2407 Biología Celularciclo celular[EN]Fidelity in chromosome duplication and segregation is indispensable for maintaining genomic stability and the perpetuation of life. Challenges to genome integrity jeopardize cell survival and are at the root of di erent types of pathologies, such as cancer. The following three main sources of genomic instability exist: DNA damage, replicative stress, and chromosome segregation defects. In response to these challenges, eukaryotic cells have evolved control mechanisms, also known as checkpoint systems, which sense under-replicated or damaged DNA and activate specialized DNA repair machineries. Cells make use of these checkpoints throughout interphase to shield genome integrity before mitosis. Later on, when the cells enter into mitosis, the spindle assembly checkpoint (SAC) is activated and remains active until the chromosomes are properly attached to the spindle apparatus to ensure an equal segregation among daughter cells. All of these processes are tightly interconnected and under strict regulation in the context of the cell division cycle. The chromosomal instability underlying cancer pathogenesis has recently emerged as a major source for understanding the mitotic processes that helps to safeguard genome integrity. Here, we review the special interconnection between the S-phase and mitosis in the presence of under-replicated DNA regions. Furthermore, we discuss what is known about the DNA damage response activated in mitosis that preserves chromosomal integrity.MDPI202420242020info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10366/154794reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésBFU2015-69709-PSA042P17CC0 1.0 Universalhttp://creativecommons.org/publicdomain/zero/1.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1547942026-06-07T06:28:51Z
dc.title.none.fl_str_mv Working on genomic stability: From the S-phase to mitosis
title Working on genomic stability: From the S-phase to mitosis
spellingShingle Working on genomic stability: From the S-phase to mitosis
Ovejero, Sara
Cell Cycle
DNA Replication
Replication Stress
Mitosis
Chromosome Instability
DNA Damage Response
Cell Cycle
2302 Bioquímica
2415 Biología Molecular
2407 Biología Celular
ciclo celular
title_short Working on genomic stability: From the S-phase to mitosis
title_full Working on genomic stability: From the S-phase to mitosis
title_fullStr Working on genomic stability: From the S-phase to mitosis
title_full_unstemmed Working on genomic stability: From the S-phase to mitosis
title_sort Working on genomic stability: From the S-phase to mitosis
dc.creator.none.fl_str_mv Ovejero, Sara
Bueno Núñez, Andrés Avelino
Sacristán Martín, María Paz
author Ovejero, Sara
author_facet Ovejero, Sara
Bueno Núñez, Andrés Avelino
Sacristán Martín, María Paz
author_role author
author2 Bueno Núñez, Andrés Avelino
Sacristán Martín, María Paz
author2_role author
author
dc.subject.none.fl_str_mv Cell Cycle
DNA Replication
Replication Stress
Mitosis
Chromosome Instability
DNA Damage Response
Cell Cycle
2302 Bioquímica
2415 Biología Molecular
2407 Biología Celular
ciclo celular
topic Cell Cycle
DNA Replication
Replication Stress
Mitosis
Chromosome Instability
DNA Damage Response
Cell Cycle
2302 Bioquímica
2415 Biología Molecular
2407 Biología Celular
ciclo celular
description [EN]Fidelity in chromosome duplication and segregation is indispensable for maintaining genomic stability and the perpetuation of life. Challenges to genome integrity jeopardize cell survival and are at the root of di erent types of pathologies, such as cancer. The following three main sources of genomic instability exist: DNA damage, replicative stress, and chromosome segregation defects. In response to these challenges, eukaryotic cells have evolved control mechanisms, also known as checkpoint systems, which sense under-replicated or damaged DNA and activate specialized DNA repair machineries. Cells make use of these checkpoints throughout interphase to shield genome integrity before mitosis. Later on, when the cells enter into mitosis, the spindle assembly checkpoint (SAC) is activated and remains active until the chromosomes are properly attached to the spindle apparatus to ensure an equal segregation among daughter cells. All of these processes are tightly interconnected and under strict regulation in the context of the cell division cycle. The chromosomal instability underlying cancer pathogenesis has recently emerged as a major source for understanding the mitotic processes that helps to safeguard genome integrity. Here, we review the special interconnection between the S-phase and mitosis in the presence of under-replicated DNA regions. Furthermore, we discuss what is known about the DNA damage response activated in mitosis that preserves chromosomal integrity.
publishDate 2020
dc.date.none.fl_str_mv 2020
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/154794
url http://hdl.handle.net/10366/154794
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv BFU2015-69709-P
SA042P17
dc.rights.none.fl_str_mv CC0 1.0 Universal
http://creativecommons.org/publicdomain/zero/1.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv CC0 1.0 Universal
http://creativecommons.org/publicdomain/zero/1.0/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411578677297152
score 15,300719

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