Current status of terpenoids as inflammasome inhibitors

Increasing evidence supports NLRP3 inflammasome as a new target to control inflammation. Dysregulation of NLRP3 inflammasome has been reported to be involved in the pathogenesis of several human inflammatory diseases. However, no NLRP3 inflammasome inhibitors are available in clinic. Terpenoids are...

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Detalles Bibliográficos
Autores: Hortelano, Sonsoles, González-Cofrade, Laura, Cuadrado, Irene, de Las Heras, Beatriz
Tipo de recurso: artículo
Fecha de publicación:2020
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/17374
Acceso en línea:http://hdl.handle.net/20.500.12105/17374
Access Level:acceso abierto
Palabra clave:Animals
Gene Expression Regulation
Humans
Inflammasomes
Inflammation
NLR Family, Pyrin Domain-Containing 3 Protein
Terpenes
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spelling Current status of terpenoids as inflammasome inhibitorsHortelano, SonsolesGonzález-Cofrade, LauraCuadrado, Irenede Las Heras, BeatrizAnimalsGene Expression RegulationHumansInflammasomesInflammationNLR Family, Pyrin Domain-Containing 3 ProteinTerpenesIncreasing evidence supports NLRP3 inflammasome as a new target to control inflammation. Dysregulation of NLRP3 inflammasome has been reported to be involved in the pathogenesis of several human inflammatory diseases. However, no NLRP3 inflammasome inhibitors are available in clinic. Terpenoids are natural products with multi-target activities against inflammation. Recent studies have revealed that these compounds are capable of inhibiting the activation of NLRP3 inflammasome in several mouse models of NLRP3 inflammasome-related pathogenesis. Thus, terpenoids represent an interesting pharmacological approach for the treatment of inflammatory diseases as they are endowed with a dual mechanism of inhibition of NF-KB transcription factor and inflammasome activation, both critically involved in their anti-inflammatory effects. This work provides an overview of the current knowledge on the therapeutic potential of terpenoids as NLRP3 inflammasome inhibitors.ElsevierInstituto de Salud Carlos IIIMinisterio de Sanidad (España)Ministerio de Economía y Competitividad (España)Ministerio de Educación, Cultura y Deporte (España)20242024-01-2520202020-02-0120202020-02-01review articlehttp://purl.org/coar/resource_type/c_dcae04bcSMURhttp://purl.org/coar/version/c_71e4c1898caa6e32info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/20.500.12105/17374reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/173742026-06-12T12:43:37Z
dc.title.none.fl_str_mv Current status of terpenoids as inflammasome inhibitors
title Current status of terpenoids as inflammasome inhibitors
spellingShingle Current status of terpenoids as inflammasome inhibitors
Hortelano, Sonsoles
Animals
Gene Expression Regulation
Humans
Inflammasomes
Inflammation
NLR Family, Pyrin Domain-Containing 3 Protein
Terpenes
title_short Current status of terpenoids as inflammasome inhibitors
title_full Current status of terpenoids as inflammasome inhibitors
title_fullStr Current status of terpenoids as inflammasome inhibitors
title_full_unstemmed Current status of terpenoids as inflammasome inhibitors
title_sort Current status of terpenoids as inflammasome inhibitors
dc.creator.none.fl_str_mv Hortelano, Sonsoles
González-Cofrade, Laura
Cuadrado, Irene
de Las Heras, Beatriz
author Hortelano, Sonsoles
author_facet Hortelano, Sonsoles
González-Cofrade, Laura
Cuadrado, Irene
de Las Heras, Beatriz
author_role author
author2 González-Cofrade, Laura
Cuadrado, Irene
de Las Heras, Beatriz
author2_role author
author
author
dc.contributor.none.fl_str_mv Instituto de Salud Carlos III
Ministerio de Sanidad (España)
Ministerio de Economía y Competitividad (España)
Ministerio de Educación, Cultura y Deporte (España)
dc.subject.none.fl_str_mv Animals
Gene Expression Regulation
Humans
Inflammasomes
Inflammation
NLR Family, Pyrin Domain-Containing 3 Protein
Terpenes
topic Animals
Gene Expression Regulation
Humans
Inflammasomes
Inflammation
NLR Family, Pyrin Domain-Containing 3 Protein
Terpenes
description Increasing evidence supports NLRP3 inflammasome as a new target to control inflammation. Dysregulation of NLRP3 inflammasome has been reported to be involved in the pathogenesis of several human inflammatory diseases. However, no NLRP3 inflammasome inhibitors are available in clinic. Terpenoids are natural products with multi-target activities against inflammation. Recent studies have revealed that these compounds are capable of inhibiting the activation of NLRP3 inflammasome in several mouse models of NLRP3 inflammasome-related pathogenesis. Thus, terpenoids represent an interesting pharmacological approach for the treatment of inflammatory diseases as they are endowed with a dual mechanism of inhibition of NF-KB transcription factor and inflammasome activation, both critically involved in their anti-inflammatory effects. This work provides an overview of the current knowledge on the therapeutic potential of terpenoids as NLRP3 inflammasome inhibitors.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020-02-01
2020
2020-02-01
2024
2024-01-25
dc.type.none.fl_str_mv review article
http://purl.org/coar/resource_type/c_dcae04bc
SMUR
http://purl.org/coar/version/c_71e4c1898caa6e32
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/17374
url http://hdl.handle.net/20.500.12105/17374
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial-NoDerivatives 4.0 Internacional
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,81155

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