Pyridine Based Antitumour Compounds Acting at the Colchicine Site

[EN]Antimitotics binding at the colchicine site of tubulin are important antitumour and vascular disrupting agents. Pyridines and azines are privileged scaffolds in medicinal chemistry and in recent years many colchicine site ligands (CSL) have incorporated them into their structures with the aim of...

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Autores: Álvarez Lozano, Raquel, Aramburu Villar, Laura, Puebla Ibáñez, María Pilar, Caballero Salvador, Esther, González Díaz, Myriam, Vicente, Alba, Medarde Agustín, Manuel, Peláez Lamamie de C. Arroyo, Rafael
Tipo de recurso: artículo
Fecha de publicación:2016
País:España
Institución:Universidad de Salamanca (USAL)
Repositorio:GREDOS. Repositorio Institucional de la Universidad de Salamanca
OAI Identifier:oai:gredos.usal.es:10366/138233
Acceso en línea:http://hdl.handle.net/10366/138233
Access Level:acceso abierto
Palabra clave:Pharmaceutical chemistry
Pyridine
Drug design
Azines
Antimitotics
Tubulin
Colchicine
Antitumour
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spelling Pyridine Based Antitumour Compounds Acting at the Colchicine SiteÁlvarez Lozano, RaquelAramburu Villar, LauraPuebla Ibáñez, María PilarCaballero Salvador, EstherGonzález Díaz, MyriamVicente, AlbaMedarde Agustín, ManuelPeláez Lamamie de C. Arroyo, RafaelPharmaceutical chemistryPyridineDrug designAzinesAntimitoticsTubulinColchicineAntitumour[EN]Antimitotics binding at the colchicine site of tubulin are important antitumour and vascular disrupting agents. Pyridines and azines are privileged scaffolds in medicinal chemistry and in recent years many colchicine site ligands (CSL) have incorporated them into their structures with the aim of improving their pharmacokinetic and pharmacodynamics properties. CSL have been classified according to their chemical structures and the chemical structures of the pyridine and azine containing antimitotic compounds are described. The design principles behind the structural modifications and the achieved effect on the biological activity upon inclusion of these heterocycles are also discussed. Lessons from the achievements and failures have been extracted and future perspectives delineated.201820182016info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10366/138233reponame:GREDOS. Repositorio Institucional de la Universidad de Salamancainstname:Universidad de Salamanca (USAL)InglésSA147U13Attribution-NonCommercial-NoDerivs 4.0 Internationalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:gredos.usal.es:10366/1382332026-06-07T06:28:51Z
dc.title.none.fl_str_mv Pyridine Based Antitumour Compounds Acting at the Colchicine Site
title Pyridine Based Antitumour Compounds Acting at the Colchicine Site
spellingShingle Pyridine Based Antitumour Compounds Acting at the Colchicine Site
Álvarez Lozano, Raquel
Pharmaceutical chemistry
Pyridine
Drug design
Azines
Antimitotics
Tubulin
Colchicine
Antitumour
title_short Pyridine Based Antitumour Compounds Acting at the Colchicine Site
title_full Pyridine Based Antitumour Compounds Acting at the Colchicine Site
title_fullStr Pyridine Based Antitumour Compounds Acting at the Colchicine Site
title_full_unstemmed Pyridine Based Antitumour Compounds Acting at the Colchicine Site
title_sort Pyridine Based Antitumour Compounds Acting at the Colchicine Site
dc.creator.none.fl_str_mv Álvarez Lozano, Raquel
Aramburu Villar, Laura
Puebla Ibáñez, María Pilar
Caballero Salvador, Esther
González Díaz, Myriam
Vicente, Alba
Medarde Agustín, Manuel
Peláez Lamamie de C. Arroyo, Rafael
author Álvarez Lozano, Raquel
author_facet Álvarez Lozano, Raquel
Aramburu Villar, Laura
Puebla Ibáñez, María Pilar
Caballero Salvador, Esther
González Díaz, Myriam
Vicente, Alba
Medarde Agustín, Manuel
Peláez Lamamie de C. Arroyo, Rafael
author_role author
author2 Aramburu Villar, Laura
Puebla Ibáñez, María Pilar
Caballero Salvador, Esther
González Díaz, Myriam
Vicente, Alba
Medarde Agustín, Manuel
Peláez Lamamie de C. Arroyo, Rafael
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Pharmaceutical chemistry
Pyridine
Drug design
Azines
Antimitotics
Tubulin
Colchicine
Antitumour
topic Pharmaceutical chemistry
Pyridine
Drug design
Azines
Antimitotics
Tubulin
Colchicine
Antitumour
description [EN]Antimitotics binding at the colchicine site of tubulin are important antitumour and vascular disrupting agents. Pyridines and azines are privileged scaffolds in medicinal chemistry and in recent years many colchicine site ligands (CSL) have incorporated them into their structures with the aim of improving their pharmacokinetic and pharmacodynamics properties. CSL have been classified according to their chemical structures and the chemical structures of the pyridine and azine containing antimitotic compounds are described. The design principles behind the structural modifications and the achieved effect on the biological activity upon inclusion of these heterocycles are also discussed. Lessons from the achievements and failures have been extracted and future perspectives delineated.
publishDate 2016
dc.date.none.fl_str_mv 2016
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10366/138233
url http://hdl.handle.net/10366/138233
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv SA147U13
dc.rights.none.fl_str_mv Attribution-NonCommercial-NoDerivs 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivs 4.0 International
http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname:Universidad de Salamanca (USAL)
instname_str Universidad de Salamanca (USAL)
reponame_str GREDOS. Repositorio Institucional de la Universidad de Salamanca
collection GREDOS. Repositorio Institucional de la Universidad de Salamanca
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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