In Vitro Diagnostic Testing for Antibiotic Allergy.

Allergy to antibiotics is an important worldwide problem, with an estimated prevalence of up to 10% of the population. Reaction patterns for different antibiotics have changed in accordance with consumption trends. Most of the allergic reactions to antibiotics have been reported for betalactams, fol...

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Detalles Bibliográficos
Autores: Doña, Inmaculada, Torres, Maria J, Montañez, Maria I, Fernández, Tahia D
Tipo de recurso: artículo
Fecha de publicación:2017
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/17272
Acceso en línea:http://hdl.handle.net/20.500.12105/17272
Access Level:acceso abierto
Palabra clave:Antibiotic
drug allergy
in vitro test
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spelling In Vitro Diagnostic Testing for Antibiotic Allergy.Doña, InmaculadaTorres, Maria JMontañez, Maria IFernández, Tahia DAntibioticdrug allergyin vitro testAllergy to antibiotics is an important worldwide problem, with an estimated prevalence of up to 10% of the population. Reaction patterns for different antibiotics have changed in accordance with consumption trends. Most of the allergic reactions to antibiotics have been reported for betalactams, followed by quinolones and macrolides and, to a lesser extent, to others, such as metronidazole clindamycin and sulfonamides. The diagnostic procedure includes a detailed clinical history, which is not always possible and can be unreliable. This is usually followed by in vivo, skin, and drug provocation tests. These are not recommended for severe, potentially lifethreaten reactions or for drugs that are known to produce a high rate of false positive results. Given the limitations of in vivo tests, in vitro test can be helpful for diagnosis, despite having suboptimal sensitivity. The most highly employed techniques for diagnosing immediate reactions to antibiotics are immunoassays and basophil activation tests, while lymphocyte transformation tests are more commonly used to diagnose non-immediate reactions. In this review, we describe different in vitro techniques employed to diagnose antibiotic allergy.20242024-01-2320172017-01-0120172017-01-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/17272reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/172722026-06-12T12:43:37Z
dc.title.none.fl_str_mv In Vitro Diagnostic Testing for Antibiotic Allergy.
title In Vitro Diagnostic Testing for Antibiotic Allergy.
spellingShingle In Vitro Diagnostic Testing for Antibiotic Allergy.
Doña, Inmaculada
Antibiotic
drug allergy
in vitro test
title_short In Vitro Diagnostic Testing for Antibiotic Allergy.
title_full In Vitro Diagnostic Testing for Antibiotic Allergy.
title_fullStr In Vitro Diagnostic Testing for Antibiotic Allergy.
title_full_unstemmed In Vitro Diagnostic Testing for Antibiotic Allergy.
title_sort In Vitro Diagnostic Testing for Antibiotic Allergy.
dc.creator.none.fl_str_mv Doña, Inmaculada
Torres, Maria J
Montañez, Maria I
Fernández, Tahia D
author Doña, Inmaculada
author_facet Doña, Inmaculada
Torres, Maria J
Montañez, Maria I
Fernández, Tahia D
author_role author
author2 Torres, Maria J
Montañez, Maria I
Fernández, Tahia D
author2_role author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv Antibiotic
drug allergy
in vitro test
topic Antibiotic
drug allergy
in vitro test
description Allergy to antibiotics is an important worldwide problem, with an estimated prevalence of up to 10% of the population. Reaction patterns for different antibiotics have changed in accordance with consumption trends. Most of the allergic reactions to antibiotics have been reported for betalactams, followed by quinolones and macrolides and, to a lesser extent, to others, such as metronidazole clindamycin and sulfonamides. The diagnostic procedure includes a detailed clinical history, which is not always possible and can be unreliable. This is usually followed by in vivo, skin, and drug provocation tests. These are not recommended for severe, potentially lifethreaten reactions or for drugs that are known to produce a high rate of false positive results. Given the limitations of in vivo tests, in vitro test can be helpful for diagnosis, despite having suboptimal sensitivity. The most highly employed techniques for diagnosing immediate reactions to antibiotics are immunoassays and basophil activation tests, while lymphocyte transformation tests are more commonly used to diagnose non-immediate reactions. In this review, we describe different in vitro techniques employed to diagnose antibiotic allergy.
publishDate 2017
dc.date.none.fl_str_mv 2017
2017-01-01
2017
2017-01-01
2024
2024-01-23
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/17272
url http://hdl.handle.net/20.500.12105/17272
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
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