IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against hepatitis C virus genotype 1 or 4 in Caucasians
Objectives: The rs12979860 variant, linked to IL28B gene, predicts sustained viral response (SVR) to pegylated-interferon/ribavirin (pegIFN/RBV) therapy in Hepatitis C Virus genotype 1 or 4 (HCV-1/4)-infected patients. Recently, a functional variant, ss469415590, in linkage disequilibrium (LD) with...
| Autores: | , , , , , , , , , , , , , |
|---|---|
| Formato: | artículo |
| Fecha de publicación: | 2014 |
| País: | España |
| Recursos: | Universitat Autònoma de Barcelona |
| Repositorio: | Dipòsit Digital de Documents de la UAB |
| Idioma: | inglés |
| OAI Identifier: | oai:ddd.uab.cat:302464 |
| Acesso em linha: | https://ddd.uab.cat/record/302464 https://dx.doi.org/urn:doi:10.1371/journal.pone.0095515 |
| Access Level: | acceso abierto |
| Palavra-chave: | Adult Alleles Antiviral Agents Coinfection European Continental Ancestry Group Female Follow-Up Studies Genotype Hepacivirus Hepatitis C, Chronic Humans Interleukins Male Middle Aged Polymorphism, Single Nucleotide ROC Curve Treatment Outcome |
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IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against hepatitis C virus genotype 1 or 4 in CaucasiansReal, Luis M.|||0000-0003-4932-7429Neukam, KarinHerrero del Rio, Mª del Rocío|||0000-0002-9678-0309Guardiola, Josep M.Reiberger, Thomas|||0000-0002-4590-3583Rivero-Juarez, Antonio|||0000-0002-5813-6889Salazar, Juliana|||0000-0002-3581-4499Mandorfer, Mattias|||0000-0003-2330-0017Merino, DoloresSoriano, Vicente|||0000-0002-4624-5199Rivero Román, Antonio|||0000-0002-8643-4250Macías, Juan|||0000-0002-4778-790XPineda, Juan A.|||0000-0002-3751-0296Caruz, AntonioAdultAllelesAntiviral AgentsCoinfectionEuropean Continental Ancestry GroupFemaleFollow-Up StudiesGenotypeHepacivirusHepatitis C, ChronicHumansInterleukinsMaleMiddle AgedPolymorphism, Single NucleotideROC CurveTreatment OutcomeObjectives: The rs12979860 variant, linked to IL28B gene, predicts sustained viral response (SVR) to pegylated-interferon/ribavirin (pegIFN/RBV) therapy in Hepatitis C Virus genotype 1 or 4 (HCV-1/4)-infected patients. Recently, a functional variant, ss469415590, in linkage disequilibrium (LD) with rs12979860, has been discovered. Our objective was to assess the value of ss469415590 to predict SVR to pegIFN/RBV in Caucasian HCV-1/4-infected individuals and to compare its performance with that of rs12979860. Methods: 272 Caucasian HCV-1/4-infected patients who completed a course of pegIFN/RBV were genotyped for both rs12979860 and ss469415590 markers. Logistic regression models including factors with univariate association with SVR and each genetic marker were elaborated. The area under the receiver operating-characteristic curve (AUROC) was calculated for each model and both were compared. Results: Both markers were in LD (r = 0.82). For rs12979860, 66 (64.0%) CC versus 56 (33.1%) T allele carriers achieved SVR (Adjusted OR = 4.156, 95%CI = 2.388-7.232, p = 4.647×10). For ss469415590, 66 (66.0%) TT/TT versus 56 (32.5%) -G allele carriers (Adjusted OR = 4.783, 95% CI = 2.714-8.428, p = 6.153×10) achieved SVR. The AUROC of the model including rs12979860 was 0.742 (95%CI = 0.672-0.813) and of that based on ss469415590 was 0.756 (95%CI = 0.687-0.826) (p = 0.780). Conclusions: The ss469415590 variant shows an equivalent performance to predict SVR to pegIFN/RBV than the rs2979860 in Caucasian HCV-1/4-infected patients. © 2014 Real et al.Universitat Autònoma de Barcelona 22014-01-0120142014-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/302464https://dx.doi.org/urn:doi:10.1371/journal.pone.0095515reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengMinisterio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD12/0017open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:3024642026-06-06T12:50:31Z |
| dc.title.none.fl_str_mv |
IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against hepatitis C virus genotype 1 or 4 in Caucasians |
| title |
IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against hepatitis C virus genotype 1 or 4 in Caucasians |
| spellingShingle |
IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against hepatitis C virus genotype 1 or 4 in Caucasians Real, Luis M.|||0000-0003-4932-7429 Adult Alleles Antiviral Agents Coinfection European Continental Ancestry Group Female Follow-Up Studies Genotype Hepacivirus Hepatitis C, Chronic Humans Interleukins Male Middle Aged Polymorphism, Single Nucleotide ROC Curve Treatment Outcome |
| title_short |
IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against hepatitis C virus genotype 1 or 4 in Caucasians |
| title_full |
IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against hepatitis C virus genotype 1 or 4 in Caucasians |
| title_fullStr |
IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against hepatitis C virus genotype 1 or 4 in Caucasians |
| title_full_unstemmed |
IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against hepatitis C virus genotype 1 or 4 in Caucasians |
| title_sort |
IFNL4 ss469415590 variant shows similar performance to rs12979860 as predictor of response to treatment against hepatitis C virus genotype 1 or 4 in Caucasians |
| dc.creator.none.fl_str_mv |
Real, Luis M.|||0000-0003-4932-7429 Neukam, Karin Herrero del Rio, Mª del Rocío|||0000-0002-9678-0309 Guardiola, Josep M. Reiberger, Thomas|||0000-0002-4590-3583 Rivero-Juarez, Antonio|||0000-0002-5813-6889 Salazar, Juliana|||0000-0002-3581-4499 Mandorfer, Mattias|||0000-0003-2330-0017 Merino, Dolores Soriano, Vicente|||0000-0002-4624-5199 Rivero Román, Antonio|||0000-0002-8643-4250 Macías, Juan|||0000-0002-4778-790X Pineda, Juan A.|||0000-0002-3751-0296 Caruz, Antonio |
| author |
Real, Luis M.|||0000-0003-4932-7429 |
| author_facet |
Real, Luis M.|||0000-0003-4932-7429 Neukam, Karin Herrero del Rio, Mª del Rocío|||0000-0002-9678-0309 Guardiola, Josep M. Reiberger, Thomas|||0000-0002-4590-3583 Rivero-Juarez, Antonio|||0000-0002-5813-6889 Salazar, Juliana|||0000-0002-3581-4499 Mandorfer, Mattias|||0000-0003-2330-0017 Merino, Dolores Soriano, Vicente|||0000-0002-4624-5199 Rivero Román, Antonio|||0000-0002-8643-4250 Macías, Juan|||0000-0002-4778-790X Pineda, Juan A.|||0000-0002-3751-0296 Caruz, Antonio |
| author_role |
author |
| author2 |
Neukam, Karin Herrero del Rio, Mª del Rocío|||0000-0002-9678-0309 Guardiola, Josep M. Reiberger, Thomas|||0000-0002-4590-3583 Rivero-Juarez, Antonio|||0000-0002-5813-6889 Salazar, Juliana|||0000-0002-3581-4499 Mandorfer, Mattias|||0000-0003-2330-0017 Merino, Dolores Soriano, Vicente|||0000-0002-4624-5199 Rivero Román, Antonio|||0000-0002-8643-4250 Macías, Juan|||0000-0002-4778-790X Pineda, Juan A.|||0000-0002-3751-0296 Caruz, Antonio |
| author2_role |
author author author author author author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universitat Autònoma de Barcelona |
| dc.subject.none.fl_str_mv |
Adult Alleles Antiviral Agents Coinfection European Continental Ancestry Group Female Follow-Up Studies Genotype Hepacivirus Hepatitis C, Chronic Humans Interleukins Male Middle Aged Polymorphism, Single Nucleotide ROC Curve Treatment Outcome |
| topic |
Adult Alleles Antiviral Agents Coinfection European Continental Ancestry Group Female Follow-Up Studies Genotype Hepacivirus Hepatitis C, Chronic Humans Interleukins Male Middle Aged Polymorphism, Single Nucleotide ROC Curve Treatment Outcome |
| description |
Objectives: The rs12979860 variant, linked to IL28B gene, predicts sustained viral response (SVR) to pegylated-interferon/ribavirin (pegIFN/RBV) therapy in Hepatitis C Virus genotype 1 or 4 (HCV-1/4)-infected patients. Recently, a functional variant, ss469415590, in linkage disequilibrium (LD) with rs12979860, has been discovered. Our objective was to assess the value of ss469415590 to predict SVR to pegIFN/RBV in Caucasian HCV-1/4-infected individuals and to compare its performance with that of rs12979860. Methods: 272 Caucasian HCV-1/4-infected patients who completed a course of pegIFN/RBV were genotyped for both rs12979860 and ss469415590 markers. Logistic regression models including factors with univariate association with SVR and each genetic marker were elaborated. The area under the receiver operating-characteristic curve (AUROC) was calculated for each model and both were compared. Results: Both markers were in LD (r = 0.82). For rs12979860, 66 (64.0%) CC versus 56 (33.1%) T allele carriers achieved SVR (Adjusted OR = 4.156, 95%CI = 2.388-7.232, p = 4.647×10). For ss469415590, 66 (66.0%) TT/TT versus 56 (32.5%) -G allele carriers (Adjusted OR = 4.783, 95% CI = 2.714-8.428, p = 6.153×10) achieved SVR. The AUROC of the model including rs12979860 was 0.742 (95%CI = 0.672-0.813) and of that based on ss469415590 was 0.756 (95%CI = 0.687-0.826) (p = 0.780). Conclusions: The ss469415590 variant shows an equivalent performance to predict SVR to pegIFN/RBV than the rs2979860 in Caucasian HCV-1/4-infected patients. © 2014 Real et al. |
| publishDate |
2014 |
| dc.date.none.fl_str_mv |
2 2014-01-01 2014 2014-01-01 |
| dc.type.none.fl_str_mv |
Article http://purl.org/coar/resource_type/c_6501 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85 |
| dc.type.openaire.fl_str_mv |
info:eu-repo/semantics/article |
| format |
article |
| dc.identifier.none.fl_str_mv |
https://ddd.uab.cat/record/302464 https://dx.doi.org/urn:doi:10.1371/journal.pone.0095515 |
| url |
https://ddd.uab.cat/record/302464 https://dx.doi.org/urn:doi:10.1371/journal.pone.0095515 |
| dc.language.none.fl_str_mv |
Inglés eng |
| language_invalid_str_mv |
Inglés |
| language |
eng |
| dc.relation.none.fl_str_mv |
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RD12/0017 |
| dc.rights.none.fl_str_mv |
open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
| dc.rights.openaire.fl_str_mv |
info:eu-repo/semantics/openAccess |
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open access http://purl.org/coar/access_right/c_abf2 https://creativecommons.org/licenses/by/4.0/ |
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openAccess |
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application/pdf |
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reponame:Dipòsit Digital de Documents de la UAB instname:Universitat Autònoma de Barcelona |
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Universitat Autònoma de Barcelona |
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Dipòsit Digital de Documents de la UAB |
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Dipòsit Digital de Documents de la UAB |
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15.812429 |