Preparation of benzolactams by Pd(II)-catalyzed carbonylation of N-unprotected arylethylamines
An unprecedented NH2-directed Pd(II)-catalytic carbonylation of quaternary aromatic α -amino esters to yield 6-membered 10 benzolactams has been developed. The reaction shows a strong bias to 6-membered lactams over 5-membered ones. The steric hindrance around the amino group seems to be pivotal for...
| Autores: | , , , , , , |
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| Tipo de recurso: | artículo |
| Estado: | Versión aceptada para publicación |
| Fecha de publicación: | 2011 |
| País: | España |
| Institución: | Universidad de Barcelona |
| Repositorio: | Dipòsit Digital de la UB |
| OAI Identifier: | oai:diposit.ub.edu:2445/48695 |
| Acceso en línea: | https://hdl.handle.net/2445/48695 |
| Access Level: | acceso abierto |
| Palabra clave: | Pal·ladi (Element químic) Química organometàl·lica Reaccions químiques Lactames Imines Palladium Organometallic chemistry Chemical reactions Lactams |
| Sumario: | An unprecedented NH2-directed Pd(II)-catalytic carbonylation of quaternary aromatic α -amino esters to yield 6-membered 10 benzolactams has been developed. The reaction shows a strong bias to 6-membered lactams over 5-membered ones. The steric hindrance around the amino group seems to be pivotal for the success of the process. |
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