Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizons

The rapid progress in next-generation sequencing technologies has significantly contributed to our knowledge of the genetic events associated with the development, progression and treatment resistance of chronic lymphocytic leukemia patients. Together with the discovery of new driver mutations, next...

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Autores: Rodríguez-Vicente, Ana Eugenia, Bikos, Vasilis, Hernández-Sánchez, María, Malcikova, Jitka, Hernández, Jesús M., Pospisilova, Sarka
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2017
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/169280
Acceso en línea:http://hdl.handle.net/10261/169280
Access Level:acceso abierto
Palabra clave:Immunogenetics
CLL prognosis
Clonal evolution
Next-generation sequencing
Chronic lymphocytic leukemia
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spelling Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizonsRodríguez-Vicente, Ana EugeniaBikos, VasilisHernández-Sánchez, MaríaMalcikova, JitkaHernández, Jesús M.Pospisilova, SarkaImmunogeneticsCLL prognosisClonal evolutionNext-generation sequencingChronic lymphocytic leukemiaThe rapid progress in next-generation sequencing technologies has significantly contributed to our knowledge of the genetic events associated with the development, progression and treatment resistance of chronic lymphocytic leukemia patients. Together with the discovery of new driver mutations, next-generation sequencing has revealed an immense degree of both intra- and inter-tumor heterogeneity and enabled us to describe marked clonal evolution. Advances in immunogenetics may be implemented to detect minimal residual disease more sensitively and to track clonal B cell populations, their dynamics and molecular characteristics. The interpretation of these aspects is indispensable to thoroughly examine the genetic background of chronic lymphocytic leukemia. We review and discuss the recent results provided by the different next-generation sequencing techniques used in studying the chronic lymphocytic leukemia genome, as well as future perspectives in the methodologies and applications.This work received funding from the European Union Seventh Framework Programme [FP7/2007-2013] under Grant Agreement n°306242-NGS-PTL and MSMT CR (2013–2015/no.7E13008). It was also supported by grants from the Spanish Fondo de Investigaciones Sanitarias FIS 09/01543, PI12/00281 and PI15/01471, Proyectos de Investigación del SACYL 355/A/09, COST Action EuGESMA (BM0801), Fundación Manuel Solórzano, Obra Social Banca Cívica (Caja Burgos), Fundación Española de Hematología y Hemoterapia (FEHH), and by grants (RD12/0036/0069 and RD12/0036/0044) from the Red Temática de Investigación Cooperativa en Cáncer (RTICC), Instituto de Salud Carlos III (ISCIII), Spanish Ministry of Economy and Competitiveness and European Regional Development Fund (ERDF) “Una manera de hacer Europa” (CEI 2010-1-0010). AERV is supported by a grant from the Fundación Ramón Areces. MHS is fully supported by an Ayuda Predoctoral de la Junta de Castilla y León from the Fondo Social Europeo (JCYL-EDU/346/2013 PhD scholarship). SP, VB and JM were supported by AZV grants from the Ministry of Health of the Czech Republic No. 15-31834A, 15-30015A and 16-29447A, MH CR project 65269705 and MSMT CR project CEITEC2020 LQ1601 under the National Sustainability Programme II.Peer ReviewedImpact JournalsRed Temática de Investigación Cooperativa en Cáncer (España)Ministerio de Economía y Competitividad (España)Fundación Ramón ArecesJunta de Castilla y LeónMinistry of Health of the Czech RepublicFundacion de la Sociedad Española de Hematología y HemoterapiaInstituto de Salud Carlos IIIFundación Memoria de D. Samuel Solorzano BarrusoFundación Caja de BurgosEuropean CommissionConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]2018201820172018info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/169280reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/EC/FP7/306242https://doi.org/10.18632/oncotarget.19525Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/1692802026-05-22T06:33:51Z
dc.title.none.fl_str_mv Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizons
title Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizons
spellingShingle Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizons
Rodríguez-Vicente, Ana Eugenia
Immunogenetics
CLL prognosis
Clonal evolution
Next-generation sequencing
Chronic lymphocytic leukemia
title_short Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizons
title_full Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizons
title_fullStr Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizons
title_full_unstemmed Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizons
title_sort Next-generation sequencing in chronic lymphocytic leukemia: recent findings and new horizons
dc.creator.none.fl_str_mv Rodríguez-Vicente, Ana Eugenia
Bikos, Vasilis
Hernández-Sánchez, María
Malcikova, Jitka
Hernández, Jesús M.
Pospisilova, Sarka
author Rodríguez-Vicente, Ana Eugenia
author_facet Rodríguez-Vicente, Ana Eugenia
Bikos, Vasilis
Hernández-Sánchez, María
Malcikova, Jitka
Hernández, Jesús M.
Pospisilova, Sarka
author_role author
author2 Bikos, Vasilis
Hernández-Sánchez, María
Malcikova, Jitka
Hernández, Jesús M.
Pospisilova, Sarka
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Red Temática de Investigación Cooperativa en Cáncer (España)
Ministerio de Economía y Competitividad (España)
Fundación Ramón Areces
Junta de Castilla y León
Ministry of Health of the Czech Republic
Fundacion de la Sociedad Española de Hematología y Hemoterapia
Instituto de Salud Carlos III
Fundación Memoria de D. Samuel Solorzano Barruso
Fundación Caja de Burgos
European Commission
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Immunogenetics
CLL prognosis
Clonal evolution
Next-generation sequencing
Chronic lymphocytic leukemia
topic Immunogenetics
CLL prognosis
Clonal evolution
Next-generation sequencing
Chronic lymphocytic leukemia
description The rapid progress in next-generation sequencing technologies has significantly contributed to our knowledge of the genetic events associated with the development, progression and treatment resistance of chronic lymphocytic leukemia patients. Together with the discovery of new driver mutations, next-generation sequencing has revealed an immense degree of both intra- and inter-tumor heterogeneity and enabled us to describe marked clonal evolution. Advances in immunogenetics may be implemented to detect minimal residual disease more sensitively and to track clonal B cell populations, their dynamics and molecular characteristics. The interpretation of these aspects is indispensable to thoroughly examine the genetic background of chronic lymphocytic leukemia. We review and discuss the recent results provided by the different next-generation sequencing techniques used in studying the chronic lymphocytic leukemia genome, as well as future perspectives in the methodologies and applications.
publishDate 2017
dc.date.none.fl_str_mv 2017
2018
2018
2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/169280
url http://hdl.handle.net/10261/169280
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/EC/FP7/306242
https://doi.org/10.18632/oncotarget.19525
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Impact Journals
publisher.none.fl_str_mv Impact Journals
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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