How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU

Santonen, Tiina; Mahiout, Selma; Alvito, Paula; Apel, Petra; Bessems, Jos; Bil, Wieneke; Borges, Teresa; Bose-O'Reilly, Stephan; Buekers, Jurgen; Cañas Portilla, Ana Isabel; Castaño, Argelia; De Alba-González, Mercedes; Domínguez-Morueco, Noelia; Esteban-Lopez, Marta; Falnoga, Ingrid; Gerofke, Antje; González-Caballero, MCarmen; Horvat, Milena; Huuskonen, Pasi; Kadikis, Normunds; Kolossa-Gehring, Marike; Lange, Rosa; Louro, Henriqueta; Martins, Carla; Meslin, Matthieu; Niemann, Lars; Pedraza-Diaz, Susana; Plichta, Veronika; Porras, Simo P; Rousselle, Christophe; Scholten, Bernice; Silva, Maria João; Šlejkovec, Zdenka; Tratnik, Janja Snoj; Joksić, Agnes Šömen; Tarazona, Jose; Uhl, Maria; Van Nieuwenhuyse, An; Viegas, Susana; Vinggaard, Anne Marie; Woutersen, Marjolijn; Schoeters, Greet

How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU

One of the aims of the European Human Biomonitoring Initiative, HBM4EU, was to provide examples of and good practices for the effective use of human biomonitoring (HBM) data in human health risk assessment (RA). The need for such information is pressing, as previous research has indicated that regul...

Descripción completa

Detalles Bibliográficos
Autores:	Santonen, Tiina, Mahiout, Selma, Alvito, Paula, Apel, Petra, Bessems, Jos, Bil, Wieneke, Borges, Teresa, Bose-O'Reilly, Stephan, Buekers, Jurgen, Cañas Portilla, Ana Isabel, Castaño, Argelia, De Alba-González, Mercedes, Domínguez-Morueco, Noelia, Esteban-Lopez, Marta, Falnoga, Ingrid, Gerofke, Antje, González-Caballero, MCarmen, Horvat, Milena, Huuskonen, Pasi, Kadikis, Normunds, Kolossa-Gehring, Marike, Lange, Rosa, Louro, Henriqueta, Martins, Carla, Meslin, Matthieu, Niemann, Lars, Pedraza-Diaz, Susana, Plichta, Veronika, Porras, Simo P, Rousselle, Christophe, Scholten, Bernice, Silva, Maria João, Šlejkovec, Zdenka, Tratnik, Janja Snoj, Joksić, Agnes Šömen, Tarazona, Jose, Uhl, Maria, Van Nieuwenhuyse, An, Viegas, Susana, Vinggaard, Anne Marie, Woutersen, Marjolijn, Schoeters, Greet
Tipo de recurso:	artículo
Fecha de publicación:	2023
País:	España
Institución:	Instituto de Salud Carlos III (ISCIII)
Repositorio:	Repisalud
Idioma:	inglés
OAI Identifier:	oai:repisalud.isciii.es:20.500.12105/16313
Acceso en línea:	http://hdl.handle.net/20.500.12105/16313
Access Level:	acceso abierto
Palabra clave:	Biological Monitoring Mercury Humans Environmental Monitoring Policy Risk Assessment

id	ES_7be6e8a90ea4ff32dd394283ff7c57d5
oai_identifier_str	oai:repisalud.isciii.es:20.500.12105/16313
network_acronym_str	ES
network_name_str	España
repository_id_str
spelling	How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EUSantonen, TiinaMahiout, SelmaAlvito, PaulaApel, PetraBessems, JosBil, WienekeBorges, TeresaBose-O'Reilly, StephanBuekers, JurgenCañas Portilla, Ana IsabelCastaño, ArgeliaDe Alba-González, MercedesDomínguez-Morueco, NoeliaEsteban-Lopez, MartaFalnoga, IngridGerofke, AntjeGonzález-Caballero, MCarmenHorvat, MilenaHuuskonen, PasiKadikis, NormundsKolossa-Gehring, MarikeLange, RosaLouro, HenriquetaMartins, CarlaMeslin, MatthieuNiemann, LarsPedraza-Diaz, SusanaPlichta, VeronikaPorras, Simo PRousselle, ChristopheScholten, BerniceSilva, Maria JoãoŠlejkovec, ZdenkaTratnik, Janja SnojJoksić, Agnes ŠömenTarazona, JoseUhl, MariaVan Nieuwenhuyse, AnViegas, SusanaVinggaard, Anne MarieWoutersen, MarjolijnSchoeters, GreetBiological MonitoringMercuryHumansEnvironmental MonitoringPolicyRisk AssessmentOne of the aims of the European Human Biomonitoring Initiative, HBM4EU, was to provide examples of and good practices for the effective use of human biomonitoring (HBM) data in human health risk assessment (RA). The need for such information is pressing, as previous research has indicated that regulatory risk assessors generally lack knowledge and experience of the use of HBM data in RA. By recognising this gap in expertise, as well as the added value of incorporating HBM data into RA, this paper aims to support the integration of HBM into regulatory RA. Based on the work of the HBM4EU, we provide examples of different approaches to including HBM in RA and in estimations of the environmental burden of disease (EBoD), the benefits and pitfalls involved, information on the important methodological aspects to consider, and recommendations on how to overcome obstacles. The examples are derived from RAs or EBoD estimations made under the HBM4EU for the following HBM4EU priority substances: acrylamide, o-toluidine of the aniline family, aprotic solvents, arsenic, bisphenols, cadmium, diisocyanates, flame retardants, hexavalent chromium [Cr(VI)], lead, mercury, mixture of per-/poly-fluorinated compounds, mixture of pesticides, mixture of phthalates, mycotoxins, polycyclic aromatic hydrocarbons (PAHs), and the UV-filter benzophenone-3. Although the RA and EBoD work presented here is not intended to have direct regulatory implications, the results can be useful for raising awareness of possibly needed policy actions, as newly generated HBM data from HBM4EU on the current exposure of the EU population has been used in many RAs and EBoD estimations.ElsevierUnión Europea. Comisión Europea. H202020232023-07-2520232023-04-0120232023-04-01research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfapplication/pdfhttp://hdl.handle.net/20.500.12105/16313reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)InglésengEuropean Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 733032open accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial-NoDerivatives 4.0 Internacionalhttp://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/163132026-06-12T12:43:37Z
dc.title.none.fl_str_mv	How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU
title	How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU
spellingShingle	How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU Santonen, Tiina Biological Monitoring Mercury Humans Environmental Monitoring Policy Risk Assessment
title_short	How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU
title_full	How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU
title_fullStr	How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU
title_full_unstemmed	How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU
title_sort	How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU
dc.creator.none.fl_str_mv	Santonen, Tiina Mahiout, Selma Alvito, Paula Apel, Petra Bessems, Jos Bil, Wieneke Borges, Teresa Bose-O'Reilly, Stephan Buekers, Jurgen Cañas Portilla, Ana Isabel Castaño, Argelia De Alba-González, Mercedes Domínguez-Morueco, Noelia Esteban-Lopez, Marta Falnoga, Ingrid Gerofke, Antje González-Caballero, MCarmen Horvat, Milena Huuskonen, Pasi Kadikis, Normunds Kolossa-Gehring, Marike Lange, Rosa Louro, Henriqueta Martins, Carla Meslin, Matthieu Niemann, Lars Pedraza-Diaz, Susana Plichta, Veronika Porras, Simo P Rousselle, Christophe Scholten, Bernice Silva, Maria João Šlejkovec, Zdenka Tratnik, Janja Snoj Joksić, Agnes Šömen Tarazona, Jose Uhl, Maria Van Nieuwenhuyse, An Viegas, Susana Vinggaard, Anne Marie Woutersen, Marjolijn Schoeters, Greet
author	Santonen, Tiina
author_facet	Santonen, Tiina Mahiout, Selma Alvito, Paula Apel, Petra Bessems, Jos Bil, Wieneke Borges, Teresa Bose-O'Reilly, Stephan Buekers, Jurgen Cañas Portilla, Ana Isabel Castaño, Argelia De Alba-González, Mercedes Domínguez-Morueco, Noelia Esteban-Lopez, Marta Falnoga, Ingrid Gerofke, Antje González-Caballero, MCarmen Horvat, Milena Huuskonen, Pasi Kadikis, Normunds Kolossa-Gehring, Marike Lange, Rosa Louro, Henriqueta Martins, Carla Meslin, Matthieu Niemann, Lars Pedraza-Diaz, Susana Plichta, Veronika Porras, Simo P Rousselle, Christophe Scholten, Bernice Silva, Maria João Šlejkovec, Zdenka Tratnik, Janja Snoj Joksić, Agnes Šömen Tarazona, Jose Uhl, Maria Van Nieuwenhuyse, An Viegas, Susana Vinggaard, Anne Marie Woutersen, Marjolijn Schoeters, Greet
author_role	author
author2	Mahiout, Selma Alvito, Paula Apel, Petra Bessems, Jos Bil, Wieneke Borges, Teresa Bose-O'Reilly, Stephan Buekers, Jurgen Cañas Portilla, Ana Isabel Castaño, Argelia De Alba-González, Mercedes Domínguez-Morueco, Noelia Esteban-Lopez, Marta Falnoga, Ingrid Gerofke, Antje González-Caballero, MCarmen Horvat, Milena Huuskonen, Pasi Kadikis, Normunds Kolossa-Gehring, Marike Lange, Rosa Louro, Henriqueta Martins, Carla Meslin, Matthieu Niemann, Lars Pedraza-Diaz, Susana Plichta, Veronika Porras, Simo P Rousselle, Christophe Scholten, Bernice Silva, Maria João Šlejkovec, Zdenka Tratnik, Janja Snoj Joksić, Agnes Šömen Tarazona, Jose Uhl, Maria Van Nieuwenhuyse, An Viegas, Susana Vinggaard, Anne Marie Woutersen, Marjolijn Schoeters, Greet
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.contributor.none.fl_str_mv	Unión Europea. Comisión Europea. H2020
dc.subject.none.fl_str_mv	Biological Monitoring Mercury Humans Environmental Monitoring Policy Risk Assessment
topic	Biological Monitoring Mercury Humans Environmental Monitoring Policy Risk Assessment
description	One of the aims of the European Human Biomonitoring Initiative, HBM4EU, was to provide examples of and good practices for the effective use of human biomonitoring (HBM) data in human health risk assessment (RA). The need for such information is pressing, as previous research has indicated that regulatory risk assessors generally lack knowledge and experience of the use of HBM data in RA. By recognising this gap in expertise, as well as the added value of incorporating HBM data into RA, this paper aims to support the integration of HBM into regulatory RA. Based on the work of the HBM4EU, we provide examples of different approaches to including HBM in RA and in estimations of the environmental burden of disease (EBoD), the benefits and pitfalls involved, information on the important methodological aspects to consider, and recommendations on how to overcome obstacles. The examples are derived from RAs or EBoD estimations made under the HBM4EU for the following HBM4EU priority substances: acrylamide, o-toluidine of the aniline family, aprotic solvents, arsenic, bisphenols, cadmium, diisocyanates, flame retardants, hexavalent chromium [Cr(VI)], lead, mercury, mixture of per-/poly-fluorinated compounds, mixture of pesticides, mixture of phthalates, mycotoxins, polycyclic aromatic hydrocarbons (PAHs), and the UV-filter benzophenone-3. Although the RA and EBoD work presented here is not intended to have direct regulatory implications, the results can be useful for raising awareness of possibly needed policy actions, as newly generated HBM data from HBM4EU on the current exposure of the EU population has been used in many RAs and EBoD estimations.
publishDate	2023
dc.date.none.fl_str_mv	2023 2023-07-25 2023 2023-04-01 2023 2023-04-01
dc.type.none.fl_str_mv	research article http://purl.org/coar/resource_type/c_2df8fbb1 VoR http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv	info:eu-repo/semantics/article
format	article
dc.identifier.none.fl_str_mv	http://hdl.handle.net/20.500.12105/16313
url	http://hdl.handle.net/20.500.12105/16313
dc.language.none.fl_str_mv	Inglés eng
language_invalid_str_mv	Inglés
language	eng
dc.relation.none.fl_str_mv	European Commission http://dx.doi.org/10.13039/501100000780 Horizon 2020 Framework Programme 733032
dc.rights.none.fl_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv	info:eu-repo/semantics/openAccess
rights_invalid_str_mv	open access http://purl.org/coar/access_right/c_abf2 Attribution-NonCommercial-NoDerivatives 4.0 Internacional http://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv	openAccess
dc.format.none.fl_str_mv	application/pdf application/pdf
dc.publisher.none.fl_str_mv	Elsevier
publisher.none.fl_str_mv	Elsevier
dc.source.none.fl_str_mv	reponame:Repisalud instname:Instituto de Salud Carlos III (ISCIII)
instname_str	Instituto de Salud Carlos III (ISCIII)
reponame_str	Repisalud
collection	Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869411550280810496
score	15,811543

How to use human biomonitoring in chemical risk assessment: Methodological aspects, recommendations, and lessons learned from HBM4EU

Similares en LA Referencia