Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study

Background: Selenium is an essential trace mineral with potential interest for cardiovascular disease (CVD) prevention owing to its antioxidant properties. Epidemiological data on selenium status and CVD remain inconsistent. The objective of this study was to ascertain whether low serum selenium (SS...

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Autores: Gutiérrez-Bedmar, Mario, Gil, Fernando, Olmedo, Pablo, Ruiz-Canela, Miguel, Martínez-González, Miguel Ángel, Salas-Salvadó, Jordi, Babio, Nancy, Fitó, Montserrat, Del Val García, Jose Luís, Corella, Dolores, Sorlí, José V, Ros, Emilio, Fiol, Miquel, Estruch, Ramón, Santos-Lozano, José Manuel, Arós, Fernando, Serra-Majem, Lluís, Pintó, Xavier, Gómez-Gracia, Enrique, Muñoz-Bravo, Carlos
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Instituto de Salud Carlos III (ISCIII)
Repositorio:Repisalud
Idioma:inglés
OAI Identifier:oai:repisalud.isciii.es:20.500.12105/18851
Acceso en línea:http://hdl.handle.net/20.500.12105/18851
Access Level:acceso abierto
Palabra clave:PREDIMED
Cardiovascular disease
Mediterranean diet
Older populations
Serum selenium
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spelling Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control StudyGutiérrez-Bedmar, MarioGil, FernandoOlmedo, PabloRuiz-Canela, MiguelMartínez-González, Miguel ÁngelSalas-Salvadó, JordiBabio, NancyFitó, MontserratDel Val García, Jose LuísCorella, DoloresSorlí, José VRos, EmilioFiol, MiquelEstruch, RamónSantos-Lozano, José ManuelArós, FernandoSerra-Majem, LluísPintó, XavierGómez-Gracia, EnriqueMuñoz-Bravo, CarlosPREDIMEDCardiovascular diseaseMediterranean dietOlder populationsSerum seleniumBackground: Selenium is an essential trace mineral with potential interest for cardiovascular disease (CVD) prevention owing to its antioxidant properties. Epidemiological data on selenium status and CVD remain inconsistent. The objective of this study was to ascertain whether low serum selenium (SSe) concentrations are related to an increased risk of a first CVD event in a population at high cardiovascular risk. Methods: We undertook a case-control study nested within the “PREvención con DIeta MEDiterránea” (PREDIMED) trial. A total of 207 participants diagnosed with CVD (myocardial infarction, stroke, or cardiovascular death) during the follow-up period (2003−2010) were matched by sex, age, and intervention group to 436 controls by incidence density sampling. Median time between serum sample collection and subsequent CVD event occurrence was 0.94 years. SSe levels were determined using inductively coupled plasma mass spectrometry analysis. Covariates were assessed through validated questionnaires, in-person interviews, and medical record reviews. Conditional logistic regression was used to calculate multivariable-adjusted odds ratios (ORs). Results: Among women, the mean SSe concentration was lower in cases than in controls (98.5 μg/L vs. 103.8 μg/L; p = 0.016). In controls, SSe levels were directly associated with percentage of total energy intake from proteins and fish intake (p for linear trend < 0.001 and 0.049, respectively), whereas SSe concentrations were inversely associated with age, body mass index, and percentage of total energy intake from carbohydrates (p for linear trend < 0.001, 0.008 and 0.016 respectively). In the total group, we observed an inverse dose−response gradient between SSe levels and risk of CVD in the fully-adjusted model (highest vs. lowest quartile: OR = 0.47, 95% CI: 0.27−0.81; ptrend = 0.003). Conclusions: Among elderly individuals at high cardiovascular risk, high SSe concentrations within population reference values are associated with lower first CVD incidence.20242024-02-2720222022-11-1020222022-11-10research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articlehttp://hdl.handle.net/20.500.12105/18851reponame:Repisaludinstname:Instituto de Salud Carlos III (ISCIII)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repisalud.isciii.es:20.500.12105/188512026-06-12T12:43:37Z
dc.title.none.fl_str_mv Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study
title Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study
spellingShingle Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study
Gutiérrez-Bedmar, Mario
PREDIMED
Cardiovascular disease
Mediterranean diet
Older populations
Serum selenium
title_short Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study
title_full Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study
title_fullStr Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study
title_full_unstemmed Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study
title_sort Serum Selenium and Incident Cardiovascular Disease in the PREvención con DIeta MEDiterránea (PREDIMED) Trial: Nested Case-Control Study
dc.creator.none.fl_str_mv Gutiérrez-Bedmar, Mario
Gil, Fernando
Olmedo, Pablo
Ruiz-Canela, Miguel
Martínez-González, Miguel Ángel
Salas-Salvadó, Jordi
Babio, Nancy
Fitó, Montserrat
Del Val García, Jose Luís
Corella, Dolores
Sorlí, José V
Ros, Emilio
Fiol, Miquel
Estruch, Ramón
Santos-Lozano, José Manuel
Arós, Fernando
Serra-Majem, Lluís
Pintó, Xavier
Gómez-Gracia, Enrique
Muñoz-Bravo, Carlos
author Gutiérrez-Bedmar, Mario
author_facet Gutiérrez-Bedmar, Mario
Gil, Fernando
Olmedo, Pablo
Ruiz-Canela, Miguel
Martínez-González, Miguel Ángel
Salas-Salvadó, Jordi
Babio, Nancy
Fitó, Montserrat
Del Val García, Jose Luís
Corella, Dolores
Sorlí, José V
Ros, Emilio
Fiol, Miquel
Estruch, Ramón
Santos-Lozano, José Manuel
Arós, Fernando
Serra-Majem, Lluís
Pintó, Xavier
Gómez-Gracia, Enrique
Muñoz-Bravo, Carlos
author_role author
author2 Gil, Fernando
Olmedo, Pablo
Ruiz-Canela, Miguel
Martínez-González, Miguel Ángel
Salas-Salvadó, Jordi
Babio, Nancy
Fitó, Montserrat
Del Val García, Jose Luís
Corella, Dolores
Sorlí, José V
Ros, Emilio
Fiol, Miquel
Estruch, Ramón
Santos-Lozano, José Manuel
Arós, Fernando
Serra-Majem, Lluís
Pintó, Xavier
Gómez-Gracia, Enrique
Muñoz-Bravo, Carlos
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv
dc.subject.none.fl_str_mv PREDIMED
Cardiovascular disease
Mediterranean diet
Older populations
Serum selenium
topic PREDIMED
Cardiovascular disease
Mediterranean diet
Older populations
Serum selenium
description Background: Selenium is an essential trace mineral with potential interest for cardiovascular disease (CVD) prevention owing to its antioxidant properties. Epidemiological data on selenium status and CVD remain inconsistent. The objective of this study was to ascertain whether low serum selenium (SSe) concentrations are related to an increased risk of a first CVD event in a population at high cardiovascular risk. Methods: We undertook a case-control study nested within the “PREvención con DIeta MEDiterránea” (PREDIMED) trial. A total of 207 participants diagnosed with CVD (myocardial infarction, stroke, or cardiovascular death) during the follow-up period (2003−2010) were matched by sex, age, and intervention group to 436 controls by incidence density sampling. Median time between serum sample collection and subsequent CVD event occurrence was 0.94 years. SSe levels were determined using inductively coupled plasma mass spectrometry analysis. Covariates were assessed through validated questionnaires, in-person interviews, and medical record reviews. Conditional logistic regression was used to calculate multivariable-adjusted odds ratios (ORs). Results: Among women, the mean SSe concentration was lower in cases than in controls (98.5 μg/L vs. 103.8 μg/L; p = 0.016). In controls, SSe levels were directly associated with percentage of total energy intake from proteins and fish intake (p for linear trend < 0.001 and 0.049, respectively), whereas SSe concentrations were inversely associated with age, body mass index, and percentage of total energy intake from carbohydrates (p for linear trend < 0.001, 0.008 and 0.016 respectively). In the total group, we observed an inverse dose−response gradient between SSe levels and risk of CVD in the fully-adjusted model (highest vs. lowest quartile: OR = 0.47, 95% CI: 0.27−0.81; ptrend = 0.003). Conclusions: Among elderly individuals at high cardiovascular risk, high SSe concentrations within population reference values are associated with lower first CVD incidence.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-11-10
2022
2022-11-10
2024
2024-02-27
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/20.500.12105/18851
url http://hdl.handle.net/20.500.12105/18851
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.source.none.fl_str_mv reponame:Repisalud
instname:Instituto de Salud Carlos III (ISCIII)
instname_str Instituto de Salud Carlos III (ISCIII)
reponame_str Repisalud
collection Repisalud
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411549372743680
score 15.811543

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