FOXP2 expression and gray matter density in the male brains of patients with schizophrenia.

Common genetic variants of FOXP2 may contribute to schizophrenia vulnerability, but controversial results have been reported for this proposal. Here we evaluated the potential impact of the common FOXP2 rs2396753 polymorphism in schizophrenia. It was previously reported to be part of a risk haplotyp...

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Autores: Sanjuán J, Castro-Martínez XH, García-Martí G, González-Fernández J, Sanz-Requena R, Haro JM, Meana JJ, Martí-Bonmatí L, Nacher J, Sebastiá-Ortega N, Gilabert-Juan J, Moltó MD
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p18090
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18090
Access Level:acceso abierto
Palabra clave:FOXP2
Gray matter
Magnetic resonance imaging
Male
Schizophrenia
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spelling FOXP2 expression and gray matter density in the male brains of patients with schizophrenia.Sanjuán JCastro-Martínez XHGarcía-Martí GGonzález-Fernández JSanz-Requena RHaro JMMeana JJMartí-Bonmatí LNacher JSebastiá-Ortega NGilabert-Juan JMoltó MDFOXP2Gray matterMagnetic resonance imagingMaleSchizophreniaCommon genetic variants of FOXP2 may contribute to schizophrenia vulnerability, but controversial results have been reported for this proposal. Here we evaluated the potential impact of the common FOXP2 rs2396753 polymorphism in schizophrenia. It was previously reported to be part of a risk haplotype for this disease and to have significant effects on gray matter concentration in the patients. We undertook the first examination into whether rs2396753 affects the brain expression of FOXP2 and a replication study of earlier neuroimaging findings of the influence of this genetic variant on brain structure. FOXP2 expression levels were measured in postmortem prefrontal cortex samples of 84 male subjects (48 patients and 36 controls) from the CIBERSAM Brain and the Stanley Foundation Array Collections. High-resolution anatomical magnetic resonance imaging was performed on 79 male subjects (61 patients, 18 controls) using optimized voxel-based morphometry. We found differences in FOXP2 expression and brain morphometry depending on the rs2396753, relating low FOXP2 mRNA levels with reduction of gray matter density. We detected an interaction between rs2396753 and the clinical groups, showing that heterozygous patients for this polymorphism have gray matter density decrease and low FOXP2 expression comparing with the heterozygous controls. This study shows the importance of independent replication of neuroimaging genetic studies of FOXP2 as a candidate gene in schizophrenia. Furthermore, our results suggest that the FOXP2 rs2396753 affects mRNA levels, thus providing new knowledge about its significance as a potential susceptibility polymorphism in schizophrenia.SPRINGER2021info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18090Brain Imaging and BehaviorISSN: 19317557ISSNe: 19317565reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p180902026-05-27T12:37:41Z
dc.title.none.fl_str_mv FOXP2 expression and gray matter density in the male brains of patients with schizophrenia.
title FOXP2 expression and gray matter density in the male brains of patients with schizophrenia.
spellingShingle FOXP2 expression and gray matter density in the male brains of patients with schizophrenia.
Sanjuán J
FOXP2
Gray matter
Magnetic resonance imaging
Male
Schizophrenia
title_short FOXP2 expression and gray matter density in the male brains of patients with schizophrenia.
title_full FOXP2 expression and gray matter density in the male brains of patients with schizophrenia.
title_fullStr FOXP2 expression and gray matter density in the male brains of patients with schizophrenia.
title_full_unstemmed FOXP2 expression and gray matter density in the male brains of patients with schizophrenia.
title_sort FOXP2 expression and gray matter density in the male brains of patients with schizophrenia.
dc.creator.none.fl_str_mv Sanjuán J
Castro-Martínez XH
García-Martí G
González-Fernández J
Sanz-Requena R
Haro JM
Meana JJ
Martí-Bonmatí L
Nacher J
Sebastiá-Ortega N
Gilabert-Juan J
Moltó MD
author Sanjuán J
author_facet Sanjuán J
Castro-Martínez XH
García-Martí G
González-Fernández J
Sanz-Requena R
Haro JM
Meana JJ
Martí-Bonmatí L
Nacher J
Sebastiá-Ortega N
Gilabert-Juan J
Moltó MD
author_role author
author2 Castro-Martínez XH
García-Martí G
González-Fernández J
Sanz-Requena R
Haro JM
Meana JJ
Martí-Bonmatí L
Nacher J
Sebastiá-Ortega N
Gilabert-Juan J
Moltó MD
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv FOXP2
Gray matter
Magnetic resonance imaging
Male
Schizophrenia
topic FOXP2
Gray matter
Magnetic resonance imaging
Male
Schizophrenia
description Common genetic variants of FOXP2 may contribute to schizophrenia vulnerability, but controversial results have been reported for this proposal. Here we evaluated the potential impact of the common FOXP2 rs2396753 polymorphism in schizophrenia. It was previously reported to be part of a risk haplotype for this disease and to have significant effects on gray matter concentration in the patients. We undertook the first examination into whether rs2396753 affects the brain expression of FOXP2 and a replication study of earlier neuroimaging findings of the influence of this genetic variant on brain structure. FOXP2 expression levels were measured in postmortem prefrontal cortex samples of 84 male subjects (48 patients and 36 controls) from the CIBERSAM Brain and the Stanley Foundation Array Collections. High-resolution anatomical magnetic resonance imaging was performed on 79 male subjects (61 patients, 18 controls) using optimized voxel-based morphometry. We found differences in FOXP2 expression and brain morphometry depending on the rs2396753, relating low FOXP2 mRNA levels with reduction of gray matter density. We detected an interaction between rs2396753 and the clinical groups, showing that heterozygous patients for this polymorphism have gray matter density decrease and low FOXP2 expression comparing with the heterozygous controls. This study shows the importance of independent replication of neuroimaging genetic studies of FOXP2 as a candidate gene in schizophrenia. Furthermore, our results suggest that the FOXP2 rs2396753 affects mRNA levels, thus providing new knowledge about its significance as a potential susceptibility polymorphism in schizophrenia.
publishDate 2021
dc.date.none.fl_str_mv 2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18090
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=18090
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv SPRINGER
publisher.none.fl_str_mv SPRINGER
dc.source.none.fl_str_mv Brain Imaging and Behavior
ISSN: 19317557
ISSNe: 19317565
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
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