Extremely high levels of vancomycin can cause severe renal toxicity

Vancomycin has usually been associated with nephrotoxicity. Generally, this toxicity is presented as proximal tubular cells injury with or without necrosis and as acute interstitial nephritis. However, development of both lesions is uncommonly described in literature. We present a case of vancomycin...

Descripción completa

Detalles Bibliográficos
Autores: Barceló-Vidal, Jaime|||0000-0002-4609-0465, Rodríguez-García, Eva, Grau, Santiago|||0000-0002-8428-1836
Tipo de recurso: artículo
Fecha de publicación:2018
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:227985
Acceso en línea:https://ddd.uab.cat/record/227985
https://dx.doi.org/urn:doi:10.2147/IDR.S171669
Access Level:acceso abierto
Palabra clave:Vancomycin
Therapeutic drug monitoring
Nephrotoxicity
id ES_7bd0e7a23fa50a8ea200d71286163fba
oai_identifier_str oai:ddd.uab.cat:227985
network_acronym_str ES
network_name_str España
repository_id_str
spelling Extremely high levels of vancomycin can cause severe renal toxicityBarceló-Vidal, Jaime|||0000-0002-4609-0465Rodríguez-García, EvaGrau, Santiago|||0000-0002-8428-1836VancomycinTherapeutic drug monitoringNephrotoxicityVancomycin has usually been associated with nephrotoxicity. Generally, this toxicity is presented as proximal tubular cells injury with or without necrosis and as acute interstitial nephritis. However, development of both lesions is uncommonly described in literature. We present a case of vancomycin-induced nephrotoxicity resulting in both acute interstitial nephritis and tubular cells damage confirmed by renal biopsy. Peak and trough levels of 77.11 and 63.60 μg/mL, respectively, were obtained at the first plasma determination. After 8 more plasma determinations and several hemodialysis sessions, vancomycin levels were undetectable 1 month after therapy was stopped. To our knowledge, this is the case report with the highest vancomycin trough levels developing both lesions and describing total vancomycin washout after a biopsy-proven vancomycin toxicity. In conclusion, early vancomycin therapeutic drug monitoring should be performed in order to avoid toxicities where, as seen in our patient, antibiotic exposure could last around 1 month after last dose administration. 22018-01-0120182018-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/227985https://dx.doi.org/urn:doi:10.2147/IDR.S171669reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2279852026-06-06T12:50:31Z
dc.title.none.fl_str_mv Extremely high levels of vancomycin can cause severe renal toxicity
title Extremely high levels of vancomycin can cause severe renal toxicity
spellingShingle Extremely high levels of vancomycin can cause severe renal toxicity
Barceló-Vidal, Jaime|||0000-0002-4609-0465
Vancomycin
Therapeutic drug monitoring
Nephrotoxicity
title_short Extremely high levels of vancomycin can cause severe renal toxicity
title_full Extremely high levels of vancomycin can cause severe renal toxicity
title_fullStr Extremely high levels of vancomycin can cause severe renal toxicity
title_full_unstemmed Extremely high levels of vancomycin can cause severe renal toxicity
title_sort Extremely high levels of vancomycin can cause severe renal toxicity
dc.creator.none.fl_str_mv Barceló-Vidal, Jaime|||0000-0002-4609-0465
Rodríguez-García, Eva
Grau, Santiago|||0000-0002-8428-1836
author Barceló-Vidal, Jaime|||0000-0002-4609-0465
author_facet Barceló-Vidal, Jaime|||0000-0002-4609-0465
Rodríguez-García, Eva
Grau, Santiago|||0000-0002-8428-1836
author_role author
author2 Rodríguez-García, Eva
Grau, Santiago|||0000-0002-8428-1836
author2_role author
author
dc.subject.none.fl_str_mv Vancomycin
Therapeutic drug monitoring
Nephrotoxicity
topic Vancomycin
Therapeutic drug monitoring
Nephrotoxicity
description Vancomycin has usually been associated with nephrotoxicity. Generally, this toxicity is presented as proximal tubular cells injury with or without necrosis and as acute interstitial nephritis. However, development of both lesions is uncommonly described in literature. We present a case of vancomycin-induced nephrotoxicity resulting in both acute interstitial nephritis and tubular cells damage confirmed by renal biopsy. Peak and trough levels of 77.11 and 63.60 μg/mL, respectively, were obtained at the first plasma determination. After 8 more plasma determinations and several hemodialysis sessions, vancomycin levels were undetectable 1 month after therapy was stopped. To our knowledge, this is the case report with the highest vancomycin trough levels developing both lesions and describing total vancomycin washout after a biopsy-proven vancomycin toxicity. In conclusion, early vancomycin therapeutic drug monitoring should be performed in order to avoid toxicities where, as seen in our patient, antibiotic exposure could last around 1 month after last dose administration.
publishDate 2018
dc.date.none.fl_str_mv 2
2018-01-01
2018
2018-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/227985
https://dx.doi.org/urn:doi:10.2147/IDR.S171669
url https://ddd.uab.cat/record/227985
https://dx.doi.org/urn:doi:10.2147/IDR.S171669
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411543603478528
score 15,301603

Similares en LA Referencia