Association of renin–angiotensin system blockers with COVID-19 diagnosis and prognosis in patients with hypertension: a population-based study

COVID-19; Angiotensin receptor blockers; Hypertension

Detalles Bibliográficos
Autores: Sole Romeo, Maria Jose, Ribera Soler, Aida, Azancot Rivero, M Antonieta, Oristrell Santamaria, Gerard, Méndez, Leonardo, Cohen, Jordana, Ferreira González, Ignacio, Marsal Mora, Josep Ramon, Méndez Fernández, Ana Belén, Andrés Villarreal, Mireia, Barrabés, José A.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/7825
Acceso en línea:https://hdl.handle.net/11351/7825
Access Level:acceso abierto
Palabra clave:Hipertensió
COVID-19 (Malaltia) - Mortalitat
Angiotensines
DISEASES::Cardiovascular Diseases::Vascular Diseases::Hypertension
ENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::hipertensión
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network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Association of renin–angiotensin system blockers with COVID-19 diagnosis and prognosis in patients with hypertension: a population-based study
title Association of renin–angiotensin system blockers with COVID-19 diagnosis and prognosis in patients with hypertension: a population-based study
spellingShingle Association of renin–angiotensin system blockers with COVID-19 diagnosis and prognosis in patients with hypertension: a population-based study
Sole Romeo, Maria Jose
Hipertensió
COVID-19 (Malaltia) - Mortalitat
Angiotensines
DISEASES::Cardiovascular Diseases::Vascular Diseases::Hypertension
ENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::hipertensión
title_short Association of renin–angiotensin system blockers with COVID-19 diagnosis and prognosis in patients with hypertension: a population-based study
title_full Association of renin–angiotensin system blockers with COVID-19 diagnosis and prognosis in patients with hypertension: a population-based study
title_fullStr Association of renin–angiotensin system blockers with COVID-19 diagnosis and prognosis in patients with hypertension: a population-based study
title_full_unstemmed Association of renin–angiotensin system blockers with COVID-19 diagnosis and prognosis in patients with hypertension: a population-based study
title_sort Association of renin–angiotensin system blockers with COVID-19 diagnosis and prognosis in patients with hypertension: a population-based study
dc.creator.none.fl_str_mv Sole Romeo, Maria Jose
Ribera Soler, Aida
Azancot Rivero, M Antonieta
Oristrell Santamaria, Gerard
Méndez, Leonardo
Cohen, Jordana
Ferreira González, Ignacio
Marsal Mora, Josep Ramon
Méndez Fernández, Ana Belén
Andrés Villarreal, Mireia
Barrabés, José A.
author Sole Romeo, Maria Jose
author_facet Sole Romeo, Maria Jose
Ribera Soler, Aida
Azancot Rivero, M Antonieta
Oristrell Santamaria, Gerard
Méndez, Leonardo
Cohen, Jordana
Ferreira González, Ignacio
Marsal Mora, Josep Ramon
Méndez Fernández, Ana Belén
Andrés Villarreal, Mireia
Barrabés, José A.
author_role author
author2 Ribera Soler, Aida
Azancot Rivero, M Antonieta
Oristrell Santamaria, Gerard
Méndez, Leonardo
Cohen, Jordana
Ferreira González, Ignacio
Marsal Mora, Josep Ramon
Méndez Fernández, Ana Belén
Andrés Villarreal, Mireia
Barrabés, José A.
author2_role author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Soler MJ, Azancot MA] Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Grup de Recerca en Nefrologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Ribera A, Marsal JR] Servei de Cardiologia, Unitat d'Epidemiologia Cardiovascular, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. [Mendez AB, Oristrell G] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Andres M, Barrabés JA] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. [Méndez-Boo L] Departament de Salut, SISAP: Sistema d’Informació dels Serveis d’Atenció Primària, Direcció de Sistemes d’Informació, Institut Català de la Salut, Generalitat de Catalunya, Barcelona, Spain. [Cohen J] Division of Renal-Electrolyte and Hypertension, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA. [Ferreira-González I] Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Hipertensió
COVID-19 (Malaltia) - Mortalitat
Angiotensines
DISEASES::Cardiovascular Diseases::Vascular Diseases::Hypertension
ENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::hipertensión
topic Hipertensió
COVID-19 (Malaltia) - Mortalitat
Angiotensines
DISEASES::Cardiovascular Diseases::Vascular Diseases::Hypertension
ENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::hipertensión
description COVID-19; Angiotensin receptor blockers; Hypertension
publishDate 2022
dc.date.none.fl_str_mv 2022
2022
2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/7825
url https://hdl.handle.net/11351/7825
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Clinical Kidney Journal;15(1)
https://doi.org/10.1093/ckj/sfab161
dc.rights.none.fl_str_mv Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Oxford University Press
publisher.none.fl_str_mv Oxford University Press
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411538325995520
spelling Association of renin–angiotensin system blockers with COVID-19 diagnosis and prognosis in patients with hypertension: a population-based studySole Romeo, Maria JoseRibera Soler, AidaAzancot Rivero, M AntonietaOristrell Santamaria, GerardMéndez, LeonardoCohen, JordanaFerreira González, IgnacioMarsal Mora, Josep RamonMéndez Fernández, Ana BelénAndrés Villarreal, MireiaBarrabés, José A.HipertensióCOVID-19 (Malaltia) - MortalitatAngiotensinesDISEASES::Cardiovascular Diseases::Vascular Diseases::HypertensionENFERMEDADES::enfermedades cardiovasculares::enfermedades vasculares::hipertensiónCOVID-19; Angiotensin receptor blockers; HypertensionCOVID-19; Bloqueadores de los receptores de angiotensina; HipertensiónCOVID-19; Bloquejadors dels receptors d'angiotensina; HipertensióBackground The effect of renin–angiotensin system (RAS) blockade either by angiotensin-converting enzyme inhibitors (ACEis) or angiotensin-receptor blockers (ARBs) on coronavirus disease 2019 (COVID-19) susceptibility, mortality and severity is inadequately described. We examined the association between RAS blockade and COVID-19 diagnosis and prognosis in a large population-based cohort of patients with hypertension (HTN). Methods This is a cohort study using regional health records. We identified all individuals aged 18–95 years from 87 healthcare reference areas of the main health provider in Catalonia (Spain), with a history of HTN from primary care records. Data were linked to COVID-19 test results, hospital, pharmacy and mortality records from 1 March 2020 to 14 August 2020. We defined exposure to RAS blockers as the dispensation of ACEi/ARBs during the 3 months before COVID-19 diagnosis or 1 March 2020. Primary outcomes were: COVID-19 infection and severe progression in hospitalized patients with COVID-19 (the composite of need for invasive respiratory support or death). For both outcomes and for each exposure of interest (RAS blockade, ACEi or ARB) we estimated associations in age-, sex-, healthcare area- and propensity score-matched samples. Results From a cohort of 1 365 215 inhabitants we identified 305 972 patients with HTN history. Recent use of ACEi/ARBs in patients with HTN was associated with a lower 6-month cumulative incidence of COVID-19 diagnosis {3.78% [95% confidence interval (CI) 3.69–3.86%] versus 4.53% (95% CI 4.40–4.65%); P < 0.001}. In the 12 344 patients with COVID-19 infection, the use of ACEi/ARBs was not associated with a higher risk of hospitalization with need for invasive respiratory support or death [OR = 0.91 (0.71–1.15); P = 0.426]. Conclusions RAS blockade in patients with HTN is not associated with higher risk of COVID-19 infection or with a worse progression of the disease.The study was partially funded by ‘CIBER de Epidemiología y Salud Pública (CIBERESP)’.Oxford University PressInstitut Català de la Salut[Soler MJ, Azancot MA] Servei de Nefrologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Universitat Autònoma de Barcelona, Bellaterra, Spain. Grup de Recerca en Nefrologia, Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Ribera A, Marsal JR] Servei de Cardiologia, Unitat d'Epidemiologia Cardiovascular, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. [Mendez AB, Oristrell G] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. [Andres M, Barrabés JA] Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain. Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. [Méndez-Boo L] Departament de Salut, SISAP: Sistema d’Informació dels Serveis d’Atenció Primària, Direcció de Sistemes d’Informació, Institut Català de la Salut, Generalitat de Catalunya, Barcelona, Spain. [Cohen J] Division of Renal-Electrolyte and Hypertension, Center for Clinical Epidemiology and Biostatistics, Perelman School of Medicine, University of Pennsylvania, Pennsylvania, PA, USA. [Ferreira-González I] Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP), Madrid, Spain. Servei de Cardiologia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. Vall d’Hebron Institut de Recerca (VHIR), Barcelona, SpainVall d'Hebron Barcelona Hospital Campus202220222022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/11351/7825Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésClinical Kidney Journal;15(1)https://doi.org/10.1093/ckj/sfab161Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/78252026-06-12T09:38:37Z
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