Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: a 2-year diagnostic accuracy study of participants from a randomized controlled trial

Posttransplant diabetes mellitus (PTDM) and prediabetes (impaired glucose tolerance [IGT] and impaired fasting glucose [IFG]) are associated with cardiovascular events. We assessed the diagnostic performance of fasting plasma glucose (FPG) and HbA1c as alternatives to oral glucose tolerance test (OG...

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Autores: Kurnikowski, Amelie, Nordheim, Espen, Schwaiger, Elisabeth, Krenn, Simon, Harreiter, Jürgen, Kautzky-Willer, Alexandra, Leutner, Michael, Werzowa, Johannes M., Tura, Andrea, Budde, Klemens, Eller, Kathrin, Pascual Santos, Julio, Krebs, Michael, Jenssen, Trond Geir, Hecking, Manfred
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/55268
Acceso en línea:http://hdl.handle.net/10230/55268
http://dx.doi.org/10.1111/ajt.17187
Access Level:acceso abierto
Palabra clave:Trasplantació d&apos
òrgans, teixits, etc.
Ronyons--Trasplantació
Diabetis
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spelling Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: a 2-year diagnostic accuracy study of participants from a randomized controlled trialKurnikowski, AmelieNordheim, EspenSchwaiger, ElisabethKrenn, SimonHarreiter, JürgenKautzky-Willer, AlexandraLeutner, MichaelWerzowa, Johannes M.Tura, AndreaBudde, KlemensEller, KathrinPascual Santos, JulioKrebs, MichaelJenssen, Trond GeirHecking, ManfredTrasplantació d&aposòrgans, teixits, etc.Ronyons--TrasplantacióDiabetisPosttransplant diabetes mellitus (PTDM) and prediabetes (impaired glucose tolerance [IGT] and impaired fasting glucose [IFG]) are associated with cardiovascular events. We assessed the diagnostic performance of fasting plasma glucose (FPG) and HbA1c as alternatives to oral glucose tolerance test (OGTT)-derived 2-hour plasma glucose (2hPG) using sensitivity and specificity in 263 kidney transplant recipients (KTRs) from a clinical trial. Between visits at 6, 12, and 24 months after transplantation, 28%-31% of patients switched glycemic category (normal glucose tolerance [NGT], IGT/IFG, PTDM). Correlations of FPG and HbA1c against 2hPG were lower at 6 months (r = 0.59 [FPG against 2hPG]; r = 0.45 [HbA1c against 2hPG]) vs. 24 months (r = 0.73 [FPG against 2hPG]; r = 0.74 [HbA1c against 2hPG]). Up to 69% of 2hPG-defined PTDM cases were missed by conventional HbA1c and FPG thresholds. For prediabetes, concordance of FPG and HbA1c with 2hPG ranged from 6%-9%. In conclusion, in our well-defined randomized trial cohort, one-third of KTRs switched glycemic category over 2 years and although the correlations of FPG and HbA1c with 2hPG improved with time, their diagnostic concordance was poor for PTDM and, especially, prediabetes. Considering posttransplant metabolic instability, FPG's and HbA1c 's diagnostic performance, the OGTT remains indispensable to diagnose PTDM and prediabetes after kidney transplantationWiley202320232022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/55268http://dx.doi.org/10.1111/ajt.17187reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésThis is the peer reviewed version of the following article: Kurnikowski A, Nordheim E, Schwaiger E, Krenn S, Harreiter J, Kautzky-Willer A, et al. Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: a 2-year diagnostic accuracy study of participants from a randomized controlled trial. Am J Transplant. 2022 Dec; 22(12): 2880-91, which has been published in final form at http://dx.doi.org/10.1111/ajt.17187. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.info:eu-repo/semantics/openAccessoai:recercat.cat:10230/552682026-05-29T05:05:01Z
dc.title.none.fl_str_mv Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: a 2-year diagnostic accuracy study of participants from a randomized controlled trial
title Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: a 2-year diagnostic accuracy study of participants from a randomized controlled trial
spellingShingle Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: a 2-year diagnostic accuracy study of participants from a randomized controlled trial
Kurnikowski, Amelie
Trasplantació d&apos
òrgans, teixits, etc.
Ronyons--Trasplantació
Diabetis
title_short Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: a 2-year diagnostic accuracy study of participants from a randomized controlled trial
title_full Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: a 2-year diagnostic accuracy study of participants from a randomized controlled trial
title_fullStr Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: a 2-year diagnostic accuracy study of participants from a randomized controlled trial
title_full_unstemmed Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: a 2-year diagnostic accuracy study of participants from a randomized controlled trial
title_sort Criteria for prediabetes and posttransplant diabetes mellitus after kidney transplantation: a 2-year diagnostic accuracy study of participants from a randomized controlled trial
dc.creator.none.fl_str_mv Kurnikowski, Amelie
Nordheim, Espen
Schwaiger, Elisabeth
Krenn, Simon
Harreiter, Jürgen
Kautzky-Willer, Alexandra
Leutner, Michael
Werzowa, Johannes M.
Tura, Andrea
Budde, Klemens
Eller, Kathrin
Pascual Santos, Julio
Krebs, Michael
Jenssen, Trond Geir
Hecking, Manfred
author Kurnikowski, Amelie
author_facet Kurnikowski, Amelie
Nordheim, Espen
Schwaiger, Elisabeth
Krenn, Simon
Harreiter, Jürgen
Kautzky-Willer, Alexandra
Leutner, Michael
Werzowa, Johannes M.
Tura, Andrea
Budde, Klemens
Eller, Kathrin
Pascual Santos, Julio
Krebs, Michael
Jenssen, Trond Geir
Hecking, Manfred
author_role author
author2 Nordheim, Espen
Schwaiger, Elisabeth
Krenn, Simon
Harreiter, Jürgen
Kautzky-Willer, Alexandra
Leutner, Michael
Werzowa, Johannes M.
Tura, Andrea
Budde, Klemens
Eller, Kathrin
Pascual Santos, Julio
Krebs, Michael
Jenssen, Trond Geir
Hecking, Manfred
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Trasplantació d&apos
òrgans, teixits, etc.
Ronyons--Trasplantació
Diabetis
topic Trasplantació d&apos
òrgans, teixits, etc.
Ronyons--Trasplantació
Diabetis
description Posttransplant diabetes mellitus (PTDM) and prediabetes (impaired glucose tolerance [IGT] and impaired fasting glucose [IFG]) are associated with cardiovascular events. We assessed the diagnostic performance of fasting plasma glucose (FPG) and HbA1c as alternatives to oral glucose tolerance test (OGTT)-derived 2-hour plasma glucose (2hPG) using sensitivity and specificity in 263 kidney transplant recipients (KTRs) from a clinical trial. Between visits at 6, 12, and 24 months after transplantation, 28%-31% of patients switched glycemic category (normal glucose tolerance [NGT], IGT/IFG, PTDM). Correlations of FPG and HbA1c against 2hPG were lower at 6 months (r = 0.59 [FPG against 2hPG]; r = 0.45 [HbA1c against 2hPG]) vs. 24 months (r = 0.73 [FPG against 2hPG]; r = 0.74 [HbA1c against 2hPG]). Up to 69% of 2hPG-defined PTDM cases were missed by conventional HbA1c and FPG thresholds. For prediabetes, concordance of FPG and HbA1c with 2hPG ranged from 6%-9%. In conclusion, in our well-defined randomized trial cohort, one-third of KTRs switched glycemic category over 2 years and although the correlations of FPG and HbA1c with 2hPG improved with time, their diagnostic concordance was poor for PTDM and, especially, prediabetes. Considering posttransplant metabolic instability, FPG's and HbA1c 's diagnostic performance, the OGTT remains indispensable to diagnose PTDM and prediabetes after kidney transplantation
publishDate 2022
dc.date.none.fl_str_mv 2022
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/55268
http://dx.doi.org/10.1111/ajt.17187
url http://hdl.handle.net/10230/55268
http://dx.doi.org/10.1111/ajt.17187
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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