Prenatal urban environment and blood pressure trajectories from childhood to early adulthood

Background: Prenatal urban environmental exposures have been associated with blood pressure in children. The dynamic of these associations across childhood and later ages is unknown. Objectives: The purpose of this study was to assess associations of prenatal urban environmental exposures with blood...

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Detalhes bibliográficos
Autores: Gonçalves Soares, Ana, Vrijheid, Martine, Nieuwenhuijsen, Mark J., Fossati, Serena, Timpson, Nicholas J.
Tipo de documento: artigo
Estado:Versão publicada
Data de publicação:2024
País:España
Recursos:Universitat Pompeu Fabra
Repositório:Repositorio Digital de la UPF
OAI Identifier:oai:repositori.upf.edu:10230/60502
Acesso em linha:http://hdl.handle.net/10230/60502
http://dx.doi.org/10.1016/j.jacadv.2023.100808
Access Level:Acceso aberto
Palavra-chave:ALSPAC
Blood pressure
Cohorts
LongITools
Trajectories
Urban environment
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spelling Prenatal urban environment and blood pressure trajectories from childhood to early adulthoodGonçalves Soares, AnaVrijheid, MartineNieuwenhuijsen, Mark J.Fossati, SerenaTimpson, Nicholas J.ALSPACBlood pressureCohortsLongIToolsTrajectoriesUrban environmentBackground: Prenatal urban environmental exposures have been associated with blood pressure in children. The dynamic of these associations across childhood and later ages is unknown. Objectives: The purpose of this study was to assess associations of prenatal urban environmental exposures with blood pressure trajectories from childhood to early adulthood. Methods: Repeated measures of systolic blood pressure (SBP) and diastolic blood pressure (DBP) were collected in up to 7,454 participants from a UK birth cohort. Prenatal urban exposures (n = 43) covered measures of noise, air pollution, built environment, natural spaces, traffic, meteorology, and food environment. An exposome-wide association study approach was used. Linear spline mixed-effects models were used to model associations of each exposure with trajectories of blood pressure. Replication was sought in 4 independent European cohorts (up to 9,261). Results: In discovery analyses, higher humidity was associated with a faster increase (mean yearly change in SBP for an interquartile range increase in humidity: 0.29 mm Hg/y, 95% CI: 0.20-0.39) and higher temperature with a slower increase (mean yearly change in SBP per interquartile range increase in temperature: −0.17 mm Hg/y, 95% CI: −0.28 to −0.07) in SBP in childhood. Higher levels of humidity and air pollution were associated with faster increase in DBP in childhood and slower increase in adolescence. There was little evidence of an association of other exposures with change in SBP or DBP. Results for humidity and temperature, but not for air pollution, were replicated in other cohorts. Conclusions: Replicated findings suggest that higher prenatal humidity and temperature could modulate blood pressure changes across childhood.Elsevier202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfhttp://hdl.handle.net/10230/60502http://dx.doi.org/10.1016/j.jacadv.2023.100808reponame:Repositorio Digital de la UPFinstname:Universitat Pompeu FabraInglésJACC: Advances. 2024;3(2):100808© 2024 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:repositori.upf.edu:10230/605022026-06-12T07:21:37Z
dc.title.none.fl_str_mv Prenatal urban environment and blood pressure trajectories from childhood to early adulthood
title Prenatal urban environment and blood pressure trajectories from childhood to early adulthood
spellingShingle Prenatal urban environment and blood pressure trajectories from childhood to early adulthood
Gonçalves Soares, Ana
ALSPAC
Blood pressure
Cohorts
LongITools
Trajectories
Urban environment
title_short Prenatal urban environment and blood pressure trajectories from childhood to early adulthood
title_full Prenatal urban environment and blood pressure trajectories from childhood to early adulthood
title_fullStr Prenatal urban environment and blood pressure trajectories from childhood to early adulthood
title_full_unstemmed Prenatal urban environment and blood pressure trajectories from childhood to early adulthood
title_sort Prenatal urban environment and blood pressure trajectories from childhood to early adulthood
dc.creator.none.fl_str_mv Gonçalves Soares, Ana
Vrijheid, Martine
Nieuwenhuijsen, Mark J.
Fossati, Serena
Timpson, Nicholas J.
author Gonçalves Soares, Ana
author_facet Gonçalves Soares, Ana
Vrijheid, Martine
Nieuwenhuijsen, Mark J.
Fossati, Serena
Timpson, Nicholas J.
author_role author
author2 Vrijheid, Martine
Nieuwenhuijsen, Mark J.
Fossati, Serena
Timpson, Nicholas J.
author2_role author
author
author
author
dc.subject.none.fl_str_mv ALSPAC
Blood pressure
Cohorts
LongITools
Trajectories
Urban environment
topic ALSPAC
Blood pressure
Cohorts
LongITools
Trajectories
Urban environment
description Background: Prenatal urban environmental exposures have been associated with blood pressure in children. The dynamic of these associations across childhood and later ages is unknown. Objectives: The purpose of this study was to assess associations of prenatal urban environmental exposures with blood pressure trajectories from childhood to early adulthood. Methods: Repeated measures of systolic blood pressure (SBP) and diastolic blood pressure (DBP) were collected in up to 7,454 participants from a UK birth cohort. Prenatal urban exposures (n = 43) covered measures of noise, air pollution, built environment, natural spaces, traffic, meteorology, and food environment. An exposome-wide association study approach was used. Linear spline mixed-effects models were used to model associations of each exposure with trajectories of blood pressure. Replication was sought in 4 independent European cohorts (up to 9,261). Results: In discovery analyses, higher humidity was associated with a faster increase (mean yearly change in SBP for an interquartile range increase in humidity: 0.29 mm Hg/y, 95% CI: 0.20-0.39) and higher temperature with a slower increase (mean yearly change in SBP per interquartile range increase in temperature: −0.17 mm Hg/y, 95% CI: −0.28 to −0.07) in SBP in childhood. Higher levels of humidity and air pollution were associated with faster increase in DBP in childhood and slower increase in adolescence. There was little evidence of an association of other exposures with change in SBP or DBP. Results for humidity and temperature, but not for air pollution, were replicated in other cohorts. Conclusions: Replicated findings suggest that higher prenatal humidity and temperature could modulate blood pressure changes across childhood.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10230/60502
http://dx.doi.org/10.1016/j.jacadv.2023.100808
url http://hdl.handle.net/10230/60502
http://dx.doi.org/10.1016/j.jacadv.2023.100808
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv JACC: Advances. 2024;3(2):100808
dc.rights.none.fl_str_mv http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositorio Digital de la UPF
instname:Universitat Pompeu Fabra
instname_str Universitat Pompeu Fabra
reponame_str Repositorio Digital de la UPF
collection Repositorio Digital de la UPF
repository.name.fl_str_mv
repository.mail.fl_str_mv
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