Podocyte and tubular involvement in AngioJet-induced kidney injury

The AngioJet technique combines localized thrombolysis and percutaneous mechanical thrombectomy (PMT). However, PMT may cause acute kidney injury (AKI), which has been ascribed to severe mechanical haemolysis, although no renal biopsies have been reported. We now report the first renal biopsy in a p...

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Autores: Esteras, Raquel, Cannata-Ortiz, Pablo, del Palacio-Tamarit, Marta, Guerrero-Hue, Melania, García-Caballero, Cristina, Egido, Jesús, Gimeno Beltran, Javier|||0000-0001-6085-5228, Ortiz, Alberto|||0000-0002-9805-9523, Gracia-Iguacel, Carolina, Moreno Gutiérrez, Juan Antonio|||0000-0002-7468-2871
Tipo de recurso: artículo
Fecha de publicación:2019
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:236738
Acceso en línea:https://ddd.uab.cat/record/236738
https://dx.doi.org/urn:doi:10.1093/ckj/sfz104
Access Level:acceso abierto
Palabra clave:Acute kidney injury
AngioJet
Haemoglobinuria
Mechanical thrombolysis
Podocyte
Tubular cell
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spelling Podocyte and tubular involvement in AngioJet-induced kidney injuryEsteras, RaquelCannata-Ortiz, Pablodel Palacio-Tamarit, MartaGuerrero-Hue, MelaniaGarcía-Caballero, CristinaEgido, JesúsGimeno Beltran, Javier|||0000-0001-6085-5228Ortiz, Alberto|||0000-0002-9805-9523Gracia-Iguacel, CarolinaMoreno Gutiérrez, Juan Antonio|||0000-0002-7468-2871Acute kidney injuryAngioJetHaemoglobinuriaMechanical thrombolysisPodocyteTubular cellThe AngioJet technique combines localized thrombolysis and percutaneous mechanical thrombectomy (PMT). However, PMT may cause acute kidney injury (AKI), which has been ascribed to severe mechanical haemolysis, although no renal biopsies have been reported. We now report the first renal biopsy in a patient with AKI following PMT. There is histological evidence of haemoglobin (Hb)-induced tubular injury and podocyte stress characterized by intracellular Hb and staining for ferritin and hemo-oxygenase-1, suggestive of an adaptive response to oxidative stress. This confirms that Hb is involved in kidney cell injury and supports the existence of several different kidney cellular targets.Universitat Autònoma de Barcelona 22019-01-0120192019-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/236738https://dx.doi.org/urn:doi:10.1093/ckj/sfz104reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengInstituto de Salud Carlos III https://doi.org/10.13039/501100004587 CP16-00017Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI16-02057Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17-00130Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/01495Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD016-0009Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RYC-2017-22369Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 FI18-00310open accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2367382026-06-06T12:50:31Z
dc.title.none.fl_str_mv Podocyte and tubular involvement in AngioJet-induced kidney injury
title Podocyte and tubular involvement in AngioJet-induced kidney injury
spellingShingle Podocyte and tubular involvement in AngioJet-induced kidney injury
Esteras, Raquel
Acute kidney injury
AngioJet
Haemoglobinuria
Mechanical thrombolysis
Podocyte
Tubular cell
title_short Podocyte and tubular involvement in AngioJet-induced kidney injury
title_full Podocyte and tubular involvement in AngioJet-induced kidney injury
title_fullStr Podocyte and tubular involvement in AngioJet-induced kidney injury
title_full_unstemmed Podocyte and tubular involvement in AngioJet-induced kidney injury
title_sort Podocyte and tubular involvement in AngioJet-induced kidney injury
dc.creator.none.fl_str_mv Esteras, Raquel
Cannata-Ortiz, Pablo
del Palacio-Tamarit, Marta
Guerrero-Hue, Melania
García-Caballero, Cristina
Egido, Jesús
Gimeno Beltran, Javier|||0000-0001-6085-5228
Ortiz, Alberto|||0000-0002-9805-9523
Gracia-Iguacel, Carolina
Moreno Gutiérrez, Juan Antonio|||0000-0002-7468-2871
author Esteras, Raquel
author_facet Esteras, Raquel
Cannata-Ortiz, Pablo
del Palacio-Tamarit, Marta
Guerrero-Hue, Melania
García-Caballero, Cristina
Egido, Jesús
Gimeno Beltran, Javier|||0000-0001-6085-5228
Ortiz, Alberto|||0000-0002-9805-9523
Gracia-Iguacel, Carolina
Moreno Gutiérrez, Juan Antonio|||0000-0002-7468-2871
author_role author
author2 Cannata-Ortiz, Pablo
del Palacio-Tamarit, Marta
Guerrero-Hue, Melania
García-Caballero, Cristina
Egido, Jesús
Gimeno Beltran, Javier|||0000-0001-6085-5228
Ortiz, Alberto|||0000-0002-9805-9523
Gracia-Iguacel, Carolina
Moreno Gutiérrez, Juan Antonio|||0000-0002-7468-2871
author2_role author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Acute kidney injury
AngioJet
Haemoglobinuria
Mechanical thrombolysis
Podocyte
Tubular cell
topic Acute kidney injury
AngioJet
Haemoglobinuria
Mechanical thrombolysis
Podocyte
Tubular cell
description The AngioJet technique combines localized thrombolysis and percutaneous mechanical thrombectomy (PMT). However, PMT may cause acute kidney injury (AKI), which has been ascribed to severe mechanical haemolysis, although no renal biopsies have been reported. We now report the first renal biopsy in a patient with AKI following PMT. There is histological evidence of haemoglobin (Hb)-induced tubular injury and podocyte stress characterized by intracellular Hb and staining for ferritin and hemo-oxygenase-1, suggestive of an adaptive response to oxidative stress. This confirms that Hb is involved in kidney cell injury and supports the existence of several different kidney cellular targets.
publishDate 2019
dc.date.none.fl_str_mv 2
2019-01-01
2019
2019-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/236738
https://dx.doi.org/urn:doi:10.1093/ckj/sfz104
url https://ddd.uab.cat/record/236738
https://dx.doi.org/urn:doi:10.1093/ckj/sfz104
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 CP16-00017
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI16-02057
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17-00130
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 PI17/01495
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 RD016-0009
Ministerio de Economía y Competitividad https://doi.org/10.13039/501100003329 RYC-2017-22369
Instituto de Salud Carlos III https://doi.org/10.13039/501100004587 FI18-00310
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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