Prophylactic, preemptive, and curative treatment for sinusoidal obstruction syndrome/veno-occlusive disease in adult patients: a position statement from an international expert group

Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can develop after hematopoietic cell transplantation (HCT). While SOS/VOD may resolve within a few weeks in the majority of patients with mild-to-moderate disease, the...

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Bibliographic Details
Authors: Mohty, Mohamad, Malard, Florent, Abecasis, Manuel, Aerts, Erik, Alaskar, Ahmed S, Aljurf, Mahmoud, Arat, Mutlu, Bader, Peter, Baron, Frederic, Basak, Grzegorz, Bazarbachi, Ali, Blaise, Didier, Ciceri, Fabio, Corbacioglu, Selim, Dalle, Jean-Hugues, Dignan, Fiona, Fukuda, Takahiro, Huynh, Anne, Kuball, Jurgen, Lachance, Silvy, Lazarus, Hillard, Masszi, Tamas, Michallet, Mauricette, Nagler, Arnon, NiChonghaile, Mairead, Okamoto, Shinichiro, Pagliuca, Antonio, Peters, Christina, Petersen, Finn B., Richardson, Paul G, Ruutu, Tapani, Saber, Wael, Savani, Bipin N., Soiffer, Robert, Styczynski, Jan, Wallhult, Elisabeth, Yakoub-Agha, Ibrahim, Duarte Palomino, Rafael, Carreras, Enric
Format: article
Publication Date:2019
Country:España
Institution:Universidad Autónoma de Madrid
Repository:Biblos-e Archivo. Repositorio Institucional de la UAM
Language:English
OAI Identifier:oai:repositorio.uam.es:10486/695248
Online Access:http://hdl.handle.net/10486/695248
https://dx.doi.org/10.1038/s41409-019-0705-z
Access Level:Open access
Keyword:Veno-occlusive disease (SOS/VOD
Hematopoietic cell transplantation (HCT)
Consensus guideline
Medicina
Description
Summary:Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), is a potentially life-threatening complication that can develop after hematopoietic cell transplantation (HCT). While SOS/VOD may resolve within a few weeks in the majority of patients with mild-to-moderate disease, the most severe forms result in multiorgan dysfunction and are associated with a high mortality rate (>80%). Therefore, careful surveillance may allow early detection of SOS/VOD, particularly as the licensed available drug is proven to be effective and reduce mortality. The aim of this work is to propose an international consensus guideline for the treatment and prevention of SOS/VOD in adult patients, on behalf of an international expert group

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