eIF5A is activated by virus infection or dsRNA and facilitates virus replication through modulation of interferon production

Active hypusine-modified initiation elongation factor 5A is critical for cell proliferation and differentiation, embryonic development, and innate immune response of macrophages to bacterial infection. Here, we demonstrate that both virus infection and double-stranded RNA viral mimic stimulation ind...

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Autores: Seoane, R, Llamas-Gonzalez, YY, Vidal, S, El Motiam, A, Bouzaher, YH, Fonseca, D, Farras, R, Garcia-Sastre, A, Gonzalez-Santamaria, J, Rivas, C
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Centro de Investigación Principe Felipe (CIPF)
Repositorio:r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
OAI Identifier:oai:cipf.fundanetsuite.com:p3941
Acceso en línea:https://cipf.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3941
Access Level:acceso abierto
Palabra clave:hypusine
virus
dsRNA
GC7
influenza
interferon
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spelling eIF5A is activated by virus infection or dsRNA and facilitates virus replication through modulation of interferon productionSeoane, RLlamas-Gonzalez, YYVidal, SEl Motiam, ABouzaher, YHFonseca, DFarras, RGarcia-Sastre, AGonzalez-Santamaria, JRivas, ChypusinevirusdsRNAGC7influenzainterferonActive hypusine-modified initiation elongation factor 5A is critical for cell proliferation and differentiation, embryonic development, and innate immune response of macrophages to bacterial infection. Here, we demonstrate that both virus infection and double-stranded RNA viral mimic stimulation induce the hypusination of eIF5A. Furthermore, we show that activation of eIF5A is essential for the replication of several RNA viruses including influenza A virus, vesicular stomatitis virus, chikungunya virus, mayaro virus, una virus, zika virus, and punta toro virus. Finally, our data reveal that inhibition of eIF5A hypusination using the spermidine analog GC7 or siRNA-mediated downmodulation of eIF5A1 induce upregulation of endoplasmic reticulum stress marker proteins and trigger the transcriptional induction of interferon and interferon-stimulated genes, mechanisms that may explain the broad-spectrum antiviral activity of eIF5A inhibition.FRONTIERS MEDIA SA2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://cipf.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3941Frontiers in Cellular and Infection MicrobiologyISSN: 22352988reponame:r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)instname:Centro de Investigación Principe Felipe (CIPF)Inglésinfo:eu-repo/semantics/openAccessoai:cipf.fundanetsuite.com:p39412026-06-17T11:19:47Z
dc.title.none.fl_str_mv eIF5A is activated by virus infection or dsRNA and facilitates virus replication through modulation of interferon production
title eIF5A is activated by virus infection or dsRNA and facilitates virus replication through modulation of interferon production
spellingShingle eIF5A is activated by virus infection or dsRNA and facilitates virus replication through modulation of interferon production
Seoane, R
hypusine
virus
dsRNA
GC7
influenza
interferon
title_short eIF5A is activated by virus infection or dsRNA and facilitates virus replication through modulation of interferon production
title_full eIF5A is activated by virus infection or dsRNA and facilitates virus replication through modulation of interferon production
title_fullStr eIF5A is activated by virus infection or dsRNA and facilitates virus replication through modulation of interferon production
title_full_unstemmed eIF5A is activated by virus infection or dsRNA and facilitates virus replication through modulation of interferon production
title_sort eIF5A is activated by virus infection or dsRNA and facilitates virus replication through modulation of interferon production
dc.creator.none.fl_str_mv Seoane, R
Llamas-Gonzalez, YY
Vidal, S
El Motiam, A
Bouzaher, YH
Fonseca, D
Farras, R
Garcia-Sastre, A
Gonzalez-Santamaria, J
Rivas, C
author Seoane, R
author_facet Seoane, R
Llamas-Gonzalez, YY
Vidal, S
El Motiam, A
Bouzaher, YH
Fonseca, D
Farras, R
Garcia-Sastre, A
Gonzalez-Santamaria, J
Rivas, C
author_role author
author2 Llamas-Gonzalez, YY
Vidal, S
El Motiam, A
Bouzaher, YH
Fonseca, D
Farras, R
Garcia-Sastre, A
Gonzalez-Santamaria, J
Rivas, C
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv hypusine
virus
dsRNA
GC7
influenza
interferon
topic hypusine
virus
dsRNA
GC7
influenza
interferon
description Active hypusine-modified initiation elongation factor 5A is critical for cell proliferation and differentiation, embryonic development, and innate immune response of macrophages to bacterial infection. Here, we demonstrate that both virus infection and double-stranded RNA viral mimic stimulation induce the hypusination of eIF5A. Furthermore, we show that activation of eIF5A is essential for the replication of several RNA viruses including influenza A virus, vesicular stomatitis virus, chikungunya virus, mayaro virus, una virus, zika virus, and punta toro virus. Finally, our data reveal that inhibition of eIF5A hypusination using the spermidine analog GC7 or siRNA-mediated downmodulation of eIF5A1 induce upregulation of endoplasmic reticulum stress marker proteins and trigger the transcriptional induction of interferon and interferon-stimulated genes, mechanisms that may explain the broad-spectrum antiviral activity of eIF5A inhibition.
publishDate 2022
dc.date.none.fl_str_mv 2022
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://cipf.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3941
url https://cipf.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=3941
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv FRONTIERS MEDIA SA
publisher.none.fl_str_mv FRONTIERS MEDIA SA
dc.source.none.fl_str_mv Frontiers in Cellular and Infection Microbiology
ISSN: 22352988
reponame:r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
instname:Centro de Investigación Principe Felipe (CIPF)
instname_str Centro de Investigación Principe Felipe (CIPF)
reponame_str r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
collection r-CIPF. Repositorio Institucional Producción Científica del Centro de Investigación Principe Felipe (CIPF)
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.811543

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