Cobalt-catalyzed C−H annulation of aliphatic amides with maleimides: Chemodivergent (4+1) and (3+2) pathways

Chemodivergent C–H annulation of aliphatic amides with maleimides has been achieved under cobaltcatalysis, enabling access to distinct (4 + 1) and (3 + 2) outcomes. These protocols, utilizing a readily available CoII-catalyst, deliver a powerful strategy for the synthesis of a diverse range of spiro...

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Detalles Bibliográficos
Autores: Sánchez González, Celia, Carretero Gonzálvez, Juan Carlos, Alonso Montero, María Inés, Rodríguez Garrido, Nuria, Adrio Sevilla, Francisco Javier
Tipo de recurso: artículo
Fecha de publicación:2026
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:dnet:biblosearchi::86009ce49afab625d6380703556c1439
Acceso en línea:https://hdl.handle.net/10486/759100
https://dx.doi.org/10.1039/D6QO00080K
Access Level:acceso abierto
Palabra clave:Amides
Aspartame
Catalysis
Cobalt compounds
Química
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spelling Cobalt-catalyzed C−H annulation of aliphatic amides with maleimides: Chemodivergent (4+1) and (3+2) pathwaysSánchez González, CeliaCarretero Gonzálvez, Juan CarlosAlonso Montero, María InésRodríguez Garrido, NuriaAdrio Sevilla, Francisco JavierAmidesAspartameCatalysisCobalt compoundsQuímicaChemodivergent C–H annulation of aliphatic amides with maleimides has been achieved under cobaltcatalysis, enabling access to distinct (4 + 1) and (3 + 2) outcomes. These protocols, utilizing a readily available CoII-catalyst, deliver a powerful strategy for the synthesis of a diverse range of spiro-γ-lactams (spiropyrrolidin-2-ones) and bicyclic pyrrolidin-2,5-diones. The combination of DFT and experimental studies provides mechanistic insight into both processes, revealing the origins of their diastereo- and chemoselectivityWe thank FEDER/Ministerio de Ciencia, Innovación y Universidades–Agencia Estatal de Investigación (Grant PID2021-124853NB-100) for financial support. C. S.-G. thanks MICIU for a FPU predoctoral fellowship (FPU21/04031RSCDepartamento de Química OrgánicaFacultad de CienciasGobierno de España20262026-02-19research articlehttp://purl.org/coar/resource_type/c_2df8fbb1VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/10486/759100https://dx.doi.org/10.1039/D6QO00080Kreponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Attribution-NonCommercial 4.0 Internationalhttp://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:dnet:biblosearchi::86009ce49afab625d6380703556c14392026-06-23T12:46:27Z
dc.title.none.fl_str_mv Cobalt-catalyzed C−H annulation of aliphatic amides with maleimides: Chemodivergent (4+1) and (3+2) pathways
title Cobalt-catalyzed C−H annulation of aliphatic amides with maleimides: Chemodivergent (4+1) and (3+2) pathways
spellingShingle Cobalt-catalyzed C−H annulation of aliphatic amides with maleimides: Chemodivergent (4+1) and (3+2) pathways
Sánchez González, Celia
Amides
Aspartame
Catalysis
Cobalt compounds
Química
title_short Cobalt-catalyzed C−H annulation of aliphatic amides with maleimides: Chemodivergent (4+1) and (3+2) pathways
title_full Cobalt-catalyzed C−H annulation of aliphatic amides with maleimides: Chemodivergent (4+1) and (3+2) pathways
title_fullStr Cobalt-catalyzed C−H annulation of aliphatic amides with maleimides: Chemodivergent (4+1) and (3+2) pathways
title_full_unstemmed Cobalt-catalyzed C−H annulation of aliphatic amides with maleimides: Chemodivergent (4+1) and (3+2) pathways
title_sort Cobalt-catalyzed C−H annulation of aliphatic amides with maleimides: Chemodivergent (4+1) and (3+2) pathways
dc.creator.none.fl_str_mv Sánchez González, Celia
Carretero Gonzálvez, Juan Carlos
Alonso Montero, María Inés
Rodríguez Garrido, Nuria
Adrio Sevilla, Francisco Javier
author Sánchez González, Celia
author_facet Sánchez González, Celia
Carretero Gonzálvez, Juan Carlos
Alonso Montero, María Inés
Rodríguez Garrido, Nuria
Adrio Sevilla, Francisco Javier
author_role author
author2 Carretero Gonzálvez, Juan Carlos
Alonso Montero, María Inés
Rodríguez Garrido, Nuria
Adrio Sevilla, Francisco Javier
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Química Orgánica
Facultad de Ciencias
Gobierno de España
dc.subject.none.fl_str_mv Amides
Aspartame
Catalysis
Cobalt compounds
Química
topic Amides
Aspartame
Catalysis
Cobalt compounds
Química
description Chemodivergent C–H annulation of aliphatic amides with maleimides has been achieved under cobaltcatalysis, enabling access to distinct (4 + 1) and (3 + 2) outcomes. These protocols, utilizing a readily available CoII-catalyst, deliver a powerful strategy for the synthesis of a diverse range of spiro-γ-lactams (spiropyrrolidin-2-ones) and bicyclic pyrrolidin-2,5-diones. The combination of DFT and experimental studies provides mechanistic insight into both processes, revealing the origins of their diastereo- and chemoselectivity
publishDate 2026
dc.date.none.fl_str_mv 2026
2026-02-19
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/10486/759100
https://dx.doi.org/10.1039/D6QO00080K
url https://hdl.handle.net/10486/759100
https://dx.doi.org/10.1039/D6QO00080K
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Attribution-NonCommercial 4.0 International
http://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv RSC
publisher.none.fl_str_mv RSC
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
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