Evolution and Development of Amygdala Subdivisions: Pallial, Subpallial, and Beyond

The amygdala is a central node in functional networks regulating emotions, social behavior, and social cognition. It develops in the telencephalon and includes pallial and subpallial parts, but these are extremely complex with multiple subdivisions, cell types, and connections. The homology of the a...

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Autores: Medina Hernández, Loreta Mª, Abellán Ródenas, Antonio, Morales García, Lorena, Pross, Alessandra, Hanafi-Metwalli, Alek, González Alonso, Alba, Freixes Vidal, Júlia, Desfilis, Ester
Tipo de recurso: artículo
Estado:Versión aceptada para publicación
Fecha de publicación:2023
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/463364
Acceso en línea:https://doi.org/10.1159/000527512
https://hdl.handle.net/10459.1/463364
Access Level:acceso abierto
Palabra clave:Forebrain
Telencephalon
Dorsal ventricular ridge
Bed nucleus of the stria terminalis
Birds
Reptiles
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spelling Evolution and Development of Amygdala Subdivisions: Pallial, Subpallial, and BeyondMedina Hernández, Loreta MªAbellán Ródenas, AntonioMorales García, LorenaPross, AlessandraHanafi-Metwalli, Alek González Alonso, AlbaFreixes Vidal, JúliaDesfilis, EsterForebrainTelencephalonDorsal ventricular ridgeBed nucleus of the stria terminalisBirdsReptilesThe amygdala is a central node in functional networks regulating emotions, social behavior, and social cognition. It develops in the telencephalon and includes pallial and subpallial parts, but these are extremely complex with multiple subdivisions, cell types, and connections. The homology of the amygdala in nonmammals is highly controversial, especially for the pallial part, and we are still far from understanding general principles on its organization that are common to different groups. Here, we review data on the adult functional architecture and developmental genoarchitecture of the amygdala in different amniotes (mammals and sauropsids), which are helping to disentangle and to better understand this complex structure. The use of an evolutionary developmental biology (evo-devo) approach has helped distinguish three major divisions in the amygdala, derived from the pallium, the subpallium, and from a newly identified division called telencephalon-opto-hypothalamic domain (TOH). This approach has also helped identify homologous cell populations with identical embryonic origins and molecular profiles in the amygdala of different amniotes. While subpallial cells produce different subtypes of GABAergic neurons, the pallium and TOH are major sources of glutamatergic cells. Available data point to a development-based molecular code that contributes to shape distinct functional subsystems in the amygdala, and comparative genoarchitecture is helping to delineate the cells involved in same subsystems in non-mammals. Thus, the evodevo approach can provide crucial information to understand common organizing principles of the amygdala cells and networks that control behavior, emotions, and cognition in amniotes.Funded by grants from the Spanish Ministerio de Ciencia e Innovación (Agencia Estatal de Investigación, Grant No. PID2019-108725RB-100) and the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie grant agreement No. 812777 (H2020- MSCA-ITN-2018-812777). LMo had a predoctoral fellowship from Universitat de Lleida i Ajuts Jade Plus, and a predoctoral contract from IRBLleida/Diputació de Lleida. AG-A had a predoctoral fellowship from Universitat de Lleida i Ajuts Jade Plus, and currently holds a predoctoral contract from AGAUR (Generalitat de Catalunya 2021 FI_B00353). JF also holds a predoctoral contract from AGAUR (Generalitat de Catalunya 2022 FI_B 00848). AHM and AP have contracts as Early-Stage Researchers paid by the H2020-MSCA-ITN-2018-812777 project. The funding agencies did not participate in the research and preparation of the manuscript.Karger Publishers2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersionapplication/pdfhttps://doi.org/10.1159/000527512https://hdl.handle.net/10459.1/463364reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)Inglésinfo:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108725RB-I00Versió postprint del document publicat a: https://doi.org/10.1159/000527512Brain Behavior and Evolution, 2023, vol. 98, num. 1, p. 1-21info:eu-repo/grantAgreement/EC/H2020/812777(c) S. Karger AG, Basel, 2022info:eu-repo/semantics/openAccessoai:repositori.udl.cat:10459.1/4633642026-06-24T12:42:17Z
dc.title.none.fl_str_mv Evolution and Development of Amygdala Subdivisions: Pallial, Subpallial, and Beyond
title Evolution and Development of Amygdala Subdivisions: Pallial, Subpallial, and Beyond
spellingShingle Evolution and Development of Amygdala Subdivisions: Pallial, Subpallial, and Beyond
Medina Hernández, Loreta Mª
Forebrain
Telencephalon
Dorsal ventricular ridge
Bed nucleus of the stria terminalis
Birds
Reptiles
title_short Evolution and Development of Amygdala Subdivisions: Pallial, Subpallial, and Beyond
title_full Evolution and Development of Amygdala Subdivisions: Pallial, Subpallial, and Beyond
title_fullStr Evolution and Development of Amygdala Subdivisions: Pallial, Subpallial, and Beyond
title_full_unstemmed Evolution and Development of Amygdala Subdivisions: Pallial, Subpallial, and Beyond
title_sort Evolution and Development of Amygdala Subdivisions: Pallial, Subpallial, and Beyond
dc.creator.none.fl_str_mv Medina Hernández, Loreta Mª
Abellán Ródenas, Antonio
Morales García, Lorena
Pross, Alessandra
Hanafi-Metwalli, Alek
González Alonso, Alba
Freixes Vidal, Júlia
Desfilis, Ester
author Medina Hernández, Loreta Mª
author_facet Medina Hernández, Loreta Mª
Abellán Ródenas, Antonio
Morales García, Lorena
Pross, Alessandra
Hanafi-Metwalli, Alek
González Alonso, Alba
Freixes Vidal, Júlia
Desfilis, Ester
author_role author
author2 Abellán Ródenas, Antonio
Morales García, Lorena
Pross, Alessandra
Hanafi-Metwalli, Alek
González Alonso, Alba
Freixes Vidal, Júlia
Desfilis, Ester
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Forebrain
Telencephalon
Dorsal ventricular ridge
Bed nucleus of the stria terminalis
Birds
Reptiles
topic Forebrain
Telencephalon
Dorsal ventricular ridge
Bed nucleus of the stria terminalis
Birds
Reptiles
description The amygdala is a central node in functional networks regulating emotions, social behavior, and social cognition. It develops in the telencephalon and includes pallial and subpallial parts, but these are extremely complex with multiple subdivisions, cell types, and connections. The homology of the amygdala in nonmammals is highly controversial, especially for the pallial part, and we are still far from understanding general principles on its organization that are common to different groups. Here, we review data on the adult functional architecture and developmental genoarchitecture of the amygdala in different amniotes (mammals and sauropsids), which are helping to disentangle and to better understand this complex structure. The use of an evolutionary developmental biology (evo-devo) approach has helped distinguish three major divisions in the amygdala, derived from the pallium, the subpallium, and from a newly identified division called telencephalon-opto-hypothalamic domain (TOH). This approach has also helped identify homologous cell populations with identical embryonic origins and molecular profiles in the amygdala of different amniotes. While subpallial cells produce different subtypes of GABAergic neurons, the pallium and TOH are major sources of glutamatergic cells. Available data point to a development-based molecular code that contributes to shape distinct functional subsystems in the amygdala, and comparative genoarchitecture is helping to delineate the cells involved in same subsystems in non-mammals. Thus, the evodevo approach can provide crucial information to understand common organizing principles of the amygdala cells and networks that control behavior, emotions, and cognition in amniotes.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1159/000527512
https://hdl.handle.net/10459.1/463364
url https://doi.org/10.1159/000527512
https://hdl.handle.net/10459.1/463364
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv info:eu-repo/grantAgreement/AEI/Plan Estatal de Investigación Científica y Técnica y de Innovación 2017-2020/PID2019-108725RB-I00
Versió postprint del document publicat a: https://doi.org/10.1159/000527512
Brain Behavior and Evolution, 2023, vol. 98, num. 1, p. 1-21
info:eu-repo/grantAgreement/EC/H2020/812777
dc.rights.none.fl_str_mv (c) S. Karger AG, Basel, 2022
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) S. Karger AG, Basel, 2022
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Karger Publishers
publisher.none.fl_str_mv Karger Publishers
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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