Ceftolozane-tazobactam: when, how and why using it?

Ceftolozane-tazobactam is currently the most active antipseudomonal agent, including multidrug-resistant extensively drug-resistant strains. Tazobactam provides additional activity against many extended-spectrum beta-lactamases Enterobacterales. Ceftolozane-tazobactam is formally approved for compli...

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Detalles Bibliográficos
Autores: López Montesinos, Inmaculada, Montero, Maria Milagro, Sorli Redó, M. Luisa, Horcajada Gallego, Juan Pablo
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2021
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:10230/53689
Acceso en línea:http://hdl.handle.net/10230/53689
http://dx.doi.org/10.37201/req/s01.10.2021
Access Level:acceso abierto
Palabra clave:Anti-Bacterial Agents
Cephalosporins
Ceftolozane
Tazobactam
Colistin
Descripción
Sumario:Ceftolozane-tazobactam is currently the most active antipseudomonal agent, including multidrug-resistant extensively drug-resistant strains. Tazobactam provides additional activity against many extended-spectrum beta-lactamases Enterobacterales. Ceftolozane-tazobactam is formally approved for complicated urinary tract infection, complicated intra-abdominal infection, and hospital-acquired and ventilator-associated bacterial pneumonia. The clinical and microbiological success is over 70-80% in many series. However, resistant mutants to ceftolozane-tazobactam have been already described. Combination therapies with colistin or meropenem could be among the strategies to avoid the resistance emergence.