Salivary biomarkers in burning mouth syndrome: A systematic review and meta-analysis

The objective of this systematic review was to evaluate which salivary biomarkers are altered in patients with burning mouth syndrome (BMS) compared to a control group (CG). A comprehensive literature search was conducted in four databases. Case– control studies evaluating salivary biomarkers in BMS...

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Detalles Bibliográficos
Autores: Fernández Agra, María, González Serrano, José, De Pedro Herráez, Miguel, Virto Ruiz, Leire, Caponio, Vito Carlo Alberto, Ibáñez Prieto, Elena, Hernández Vallejo, Gonzalo, López-Pintor Muñoz, Rosa María
Tipo de recurso: artículo
Fecha de publicación:2022
País:España
Institución:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/72124
Acceso en línea:https://hdl.handle.net/20.500.14352/72124
Access Level:acceso abierto
Palabra clave:Biomarkers
Burning mouth syndrome
Saliva
Salivary biomarkers
Odontología (Odontología)
3213.13 Ortodoncia-Estomatología
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spelling Salivary biomarkers in burning mouth syndrome: A systematic review and meta-analysisFernández Agra, MaríaGonzález Serrano, JoséDe Pedro Herráez, MiguelVirto Ruiz, LeireCaponio, Vito Carlo AlbertoIbáñez Prieto, ElenaHernández Vallejo, GonzaloLópez-Pintor Muñoz, Rosa MaríaBiomarkersBurning mouth syndromeSalivaSalivary biomarkersOdontología (Odontología)3213.13 Ortodoncia-EstomatologíaThe objective of this systematic review was to evaluate which salivary biomarkers are altered in patients with burning mouth syndrome (BMS) compared to a control group (CG). A comprehensive literature search was conducted in four databases. Case– control studies evaluating salivary biomarkers in BMS patients were included. Risk of bias was assessed using the Newcastle-Ottawa tool. RevMan was used for metaanalysis. Seventeen studies were selected. The included studies collected 54 different biomarkers. Of these biomarkers, only three (cortisol, α-amylase, and dehydroepiandrosterone) were analyzed in three or more studies. Dehydroepiandrosterone obtained contradictory results among the studies. However, cortisol and α-amylase levels were found to be higher in BMS patients. Cortisol was the only biomarker which could be included for meta-analysis. Cortisol levels were significantly higher in the BMS group compared to the CG (Mean Difference = 0.39; 95% CI [0.14–0.65]; p = 0.003). In conclusion, different studies investigated salivary biomarkers in patients with BMS compared to a CG, with controversial results. Meta-analysis, confirmed by trial-sequential analysis, showed how cortisol levels were significantly higher in BMS. Cortisol emerges as an interesting salivary biomarker in BMS, but future properly designed studies are needed to evaluate its role in diagnosis and/or response to treatment.WileyUniversidad Complutense de Madrid20222022-09-2220222022-09-22journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/72124reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución-NoComercial-SinDerivadas 3.0 Españahttps://creativecommons.org/licenses/by-nc-nd/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/721242026-06-02T12:44:21Z
dc.title.none.fl_str_mv Salivary biomarkers in burning mouth syndrome: A systematic review and meta-analysis
title Salivary biomarkers in burning mouth syndrome: A systematic review and meta-analysis
spellingShingle Salivary biomarkers in burning mouth syndrome: A systematic review and meta-analysis
Fernández Agra, María
Biomarkers
Burning mouth syndrome
Saliva
Salivary biomarkers
Odontología (Odontología)
3213.13 Ortodoncia-Estomatología
title_short Salivary biomarkers in burning mouth syndrome: A systematic review and meta-analysis
title_full Salivary biomarkers in burning mouth syndrome: A systematic review and meta-analysis
title_fullStr Salivary biomarkers in burning mouth syndrome: A systematic review and meta-analysis
title_full_unstemmed Salivary biomarkers in burning mouth syndrome: A systematic review and meta-analysis
title_sort Salivary biomarkers in burning mouth syndrome: A systematic review and meta-analysis
dc.creator.none.fl_str_mv Fernández Agra, María
González Serrano, José
De Pedro Herráez, Miguel
Virto Ruiz, Leire
Caponio, Vito Carlo Alberto
Ibáñez Prieto, Elena
Hernández Vallejo, Gonzalo
López-Pintor Muñoz, Rosa María
author Fernández Agra, María
author_facet Fernández Agra, María
González Serrano, José
De Pedro Herráez, Miguel
Virto Ruiz, Leire
Caponio, Vito Carlo Alberto
Ibáñez Prieto, Elena
Hernández Vallejo, Gonzalo
López-Pintor Muñoz, Rosa María
author_role author
author2 González Serrano, José
De Pedro Herráez, Miguel
Virto Ruiz, Leire
Caponio, Vito Carlo Alberto
Ibáñez Prieto, Elena
Hernández Vallejo, Gonzalo
López-Pintor Muñoz, Rosa María
author2_role author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv Biomarkers
Burning mouth syndrome
Saliva
Salivary biomarkers
Odontología (Odontología)
3213.13 Ortodoncia-Estomatología
topic Biomarkers
Burning mouth syndrome
Saliva
Salivary biomarkers
Odontología (Odontología)
3213.13 Ortodoncia-Estomatología
description The objective of this systematic review was to evaluate which salivary biomarkers are altered in patients with burning mouth syndrome (BMS) compared to a control group (CG). A comprehensive literature search was conducted in four databases. Case– control studies evaluating salivary biomarkers in BMS patients were included. Risk of bias was assessed using the Newcastle-Ottawa tool. RevMan was used for metaanalysis. Seventeen studies were selected. The included studies collected 54 different biomarkers. Of these biomarkers, only three (cortisol, α-amylase, and dehydroepiandrosterone) were analyzed in three or more studies. Dehydroepiandrosterone obtained contradictory results among the studies. However, cortisol and α-amylase levels were found to be higher in BMS patients. Cortisol was the only biomarker which could be included for meta-analysis. Cortisol levels were significantly higher in the BMS group compared to the CG (Mean Difference = 0.39; 95% CI [0.14–0.65]; p = 0.003). In conclusion, different studies investigated salivary biomarkers in patients with BMS compared to a CG, with controversial results. Meta-analysis, confirmed by trial-sequential analysis, showed how cortisol levels were significantly higher in BMS. Cortisol emerges as an interesting salivary biomarker in BMS, but future properly designed studies are needed to evaluate its role in diagnosis and/or response to treatment.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-09-22
2022
2022-09-22
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/72124
url https://hdl.handle.net/20.500.14352/72124
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
https://creativecommons.org/licenses/by-nc-nd/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución-NoComercial-SinDerivadas 3.0 España
https://creativecommons.org/licenses/by-nc-nd/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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