Comorbid autoimmune diseases and burden of diabetes-related complications in patients with type 1 diabetes from a Mediterranean area

AIM: To assess the prevalence of autoimmune diseases (AID) in patients with type 1 diabetes (T1D) and to evaluate whether the rate of diabetes-related complications differs depending on the presence of AID. METHODS: Cross-sectional analysis of 13,570 T1D patients aged ≥ 18 years registered in the SI...

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Authors: Gimenez-Perez, Gabriel|||0000-0002-8541-766X, Vlacho, Bogdan|||0000-0003-3768-8112, Navas, Elena|||0000-0001-5823-5847, Mata-Cases, Manel|||0000-0003-3693-3622, Real, Jordi|||0000-0002-5979-8948, Cos Claramunt, Francesc Xavier|||0000-0003-3943-479X, Franch-Nadal, Josep|||0000-0002-5175-1555, Mauricio, Didac|||0000-0002-2868-0250
Format: article
Publication Date:2022
Country:España
Institution:Universitat Autònoma de Barcelona
Repository:Dipòsit Digital de Documents de la UAB
Language:English
OAI Identifier:oai:ddd.uab.cat:280883
Online Access:https://ddd.uab.cat/record/280883
https://dx.doi.org/urn:doi:10.1016/j.diabres.2022.110031
Access Level:Open access
Keyword:Type 1 diabetes mellitus
Autoimmunity
Glycemic control
Diabetes complications
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spelling Comorbid autoimmune diseases and burden of diabetes-related complications in patients with type 1 diabetes from a Mediterranean areaGimenez-Perez, Gabriel|||0000-0002-8541-766XVlacho, Bogdan|||0000-0003-3768-8112Navas, Elena|||0000-0001-5823-5847Mata-Cases, Manel|||0000-0003-3693-3622Real, Jordi|||0000-0002-5979-8948Cos Claramunt, Francesc Xavier|||0000-0003-3943-479XFranch-Nadal, Josep|||0000-0002-5175-1555Mauricio, Didac|||0000-0002-2868-0250Type 1 diabetes mellitusAutoimmunityGlycemic controlDiabetes complicationsAIM: To assess the prevalence of autoimmune diseases (AID) in patients with type 1 diabetes (T1D) and to evaluate whether the rate of diabetes-related complications differs depending on the presence of AID. METHODS: Cross-sectional analysis of 13,570 T1D patients aged ≥ 18 years registered in the SIDIAP database. The association between AID and diabetes-related complications was assessed by multivariable logistic regression models. RESULTS: The prevalence of AID was 18.3% with thyroid AID being the most common. Patients with T1D and AID were more often female and their current age, age of diabetes onset and diabetes duration were higher. Patients with only thyroid AID experienced a lower risk of peripheral artery disease (odds ratio [OR] = 0.51, 95%; confidence interval [CI] 0.31 to 0.81) and kidney disease (OR = 0.68, 95%; 95% CI 0.54 to 0.85), whereas patients with other AID had an increased risk of ischemic heart disease (OR = 1.48, 95%; 95% CI 1.04 to 2.06). CONCLUSIONS: The burden of diabetes-related complications in patients with T1D differs according to the type of additional AID. The presence of diabetes complications is lower in those with autoimmune thyroid disease while the presence of other AID is associated with higher rates of ischemic heart disease. 22022-01-0120222022-01-01Articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/280883https://dx.doi.org/urn:doi:10.1016/j.diabres.2022.110031reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2808832026-06-06T12:50:31Z
dc.title.none.fl_str_mv Comorbid autoimmune diseases and burden of diabetes-related complications in patients with type 1 diabetes from a Mediterranean area
title Comorbid autoimmune diseases and burden of diabetes-related complications in patients with type 1 diabetes from a Mediterranean area
spellingShingle Comorbid autoimmune diseases and burden of diabetes-related complications in patients with type 1 diabetes from a Mediterranean area
Gimenez-Perez, Gabriel|||0000-0002-8541-766X
Type 1 diabetes mellitus
Autoimmunity
Glycemic control
Diabetes complications
title_short Comorbid autoimmune diseases and burden of diabetes-related complications in patients with type 1 diabetes from a Mediterranean area
title_full Comorbid autoimmune diseases and burden of diabetes-related complications in patients with type 1 diabetes from a Mediterranean area
title_fullStr Comorbid autoimmune diseases and burden of diabetes-related complications in patients with type 1 diabetes from a Mediterranean area
title_full_unstemmed Comorbid autoimmune diseases and burden of diabetes-related complications in patients with type 1 diabetes from a Mediterranean area
title_sort Comorbid autoimmune diseases and burden of diabetes-related complications in patients with type 1 diabetes from a Mediterranean area
dc.creator.none.fl_str_mv Gimenez-Perez, Gabriel|||0000-0002-8541-766X
Vlacho, Bogdan|||0000-0003-3768-8112
Navas, Elena|||0000-0001-5823-5847
Mata-Cases, Manel|||0000-0003-3693-3622
Real, Jordi|||0000-0002-5979-8948
Cos Claramunt, Francesc Xavier|||0000-0003-3943-479X
Franch-Nadal, Josep|||0000-0002-5175-1555
Mauricio, Didac|||0000-0002-2868-0250
author Gimenez-Perez, Gabriel|||0000-0002-8541-766X
author_facet Gimenez-Perez, Gabriel|||0000-0002-8541-766X
Vlacho, Bogdan|||0000-0003-3768-8112
Navas, Elena|||0000-0001-5823-5847
Mata-Cases, Manel|||0000-0003-3693-3622
Real, Jordi|||0000-0002-5979-8948
Cos Claramunt, Francesc Xavier|||0000-0003-3943-479X
Franch-Nadal, Josep|||0000-0002-5175-1555
Mauricio, Didac|||0000-0002-2868-0250
author_role author
author2 Vlacho, Bogdan|||0000-0003-3768-8112
Navas, Elena|||0000-0001-5823-5847
Mata-Cases, Manel|||0000-0003-3693-3622
Real, Jordi|||0000-0002-5979-8948
Cos Claramunt, Francesc Xavier|||0000-0003-3943-479X
Franch-Nadal, Josep|||0000-0002-5175-1555
Mauricio, Didac|||0000-0002-2868-0250
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Type 1 diabetes mellitus
Autoimmunity
Glycemic control
Diabetes complications
topic Type 1 diabetes mellitus
Autoimmunity
Glycemic control
Diabetes complications
description AIM: To assess the prevalence of autoimmune diseases (AID) in patients with type 1 diabetes (T1D) and to evaluate whether the rate of diabetes-related complications differs depending on the presence of AID. METHODS: Cross-sectional analysis of 13,570 T1D patients aged ≥ 18 years registered in the SIDIAP database. The association between AID and diabetes-related complications was assessed by multivariable logistic regression models. RESULTS: The prevalence of AID was 18.3% with thyroid AID being the most common. Patients with T1D and AID were more often female and their current age, age of diabetes onset and diabetes duration were higher. Patients with only thyroid AID experienced a lower risk of peripheral artery disease (odds ratio [OR] = 0.51, 95%; confidence interval [CI] 0.31 to 0.81) and kidney disease (OR = 0.68, 95%; 95% CI 0.54 to 0.85), whereas patients with other AID had an increased risk of ischemic heart disease (OR = 1.48, 95%; 95% CI 1.04 to 2.06). CONCLUSIONS: The burden of diabetes-related complications in patients with T1D differs according to the type of additional AID. The presence of diabetes complications is lower in those with autoimmune thyroid disease while the presence of other AID is associated with higher rates of ischemic heart disease.
publishDate 2022
dc.date.none.fl_str_mv 2
2022-01-01
2022
2022-01-01
dc.type.none.fl_str_mv Article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/280883
https://dx.doi.org/urn:doi:10.1016/j.diabres.2022.110031
url https://ddd.uab.cat/record/280883
https://dx.doi.org/urn:doi:10.1016/j.diabres.2022.110031
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
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