Beyond tradition: exploring the non-canonical functions of telomeres in meiosis

The telomere bouquet is a specific chromosomal configuration that forms during meiosis at the zygotene stage, when telomeres cluster together at the nuclear envelope. This clustering allows cytoskeleton-induced movements to be transmitted to the chromosomes, thereby facilitating homologous chromosom...

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Detalles Bibliográficos
Autor: Fernández-Álvarez, Alfonso
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/347394
Acceso en línea:http://hdl.handle.net/10261/347394
https://api.elsevier.com/content/abstract/scopus_id/85177865363
Access Level:acceso abierto
Palabra clave:Bouquet
Centromere
Chromosome dynamics
Gametogenesis
Meiosis
Telomeres
Yeast
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spelling Beyond tradition: exploring the non-canonical functions of telomeres in meiosisFernández-Álvarez, AlfonsoBouquetCentromereChromosome dynamicsGametogenesisMeiosisTelomeresYeastThe telomere bouquet is a specific chromosomal configuration that forms during meiosis at the zygotene stage, when telomeres cluster together at the nuclear envelope. This clustering allows cytoskeleton-induced movements to be transmitted to the chromosomes, thereby facilitating homologous chromosome search and pairing. However, loss of the bouquet results in more severe meiotic defects than can be attributed solely to recombination problems, suggesting that the bouquet's full function remains elusive. Despite its transient nature and the challenges in performing in vivo analyses, information is emerging that points to a remarkable suite of non-canonical functions carried out by the bouquet. Here, we describe how new approaches in quantitative cell biology can contribute to establishing the molecular basis of the full function and plasticity of the bouquet, and thus generate a comprehensive picture of the telomeric control of meiosis.The author(s) declare financial support was received for the research, authorship, and/or publication of this article. This work was supported by PID 2021-127232NB-I00 funded by the MCIN/ AEI/10.13039/501100011033 and by the “FEDER, Una manera de hacer Europa”, awarded to AF-Á. The Institute of Functional Biology and Genomics (IBFG) has received funding through the program “Escalera de Excelencia” of the Regional Government of Castile and Leon (ref.: CLU-2017-03) and co-financed by the P.O. FEDER of Castilla and León 14–20, and the Internationalization Project “CL-EI-2021-08-IBFG Unit of Excellence” of the Spanish National Research Council (CSIC), funded by the Regional Government of Castile and Leon and co-financed by the European Regional Development Fund (ERDF Europe drives our growth).Peer reviewedFrontiers MediaAgencia Estatal de Investigación (España)Ministerio de Ciencia, Innovación y Universidades (España)European CommissionJunta de Castilla y LeónConsejo Superior de Investigaciones Científicas (España)Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202420242023info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionapplication/pdfhttp://hdl.handle.net/10261/347394https://api.elsevier.com/content/abstract/scopus_id/85177865363reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/AEI//PID2021-127232NB-I00The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.3389/fcell.2023.1278571https://doi.org/10.3389/fcell.2023.1278571Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/3473942026-05-22T06:33:51Z
dc.title.none.fl_str_mv Beyond tradition: exploring the non-canonical functions of telomeres in meiosis
title Beyond tradition: exploring the non-canonical functions of telomeres in meiosis
spellingShingle Beyond tradition: exploring the non-canonical functions of telomeres in meiosis
Fernández-Álvarez, Alfonso
Bouquet
Centromere
Chromosome dynamics
Gametogenesis
Meiosis
Telomeres
Yeast
title_short Beyond tradition: exploring the non-canonical functions of telomeres in meiosis
title_full Beyond tradition: exploring the non-canonical functions of telomeres in meiosis
title_fullStr Beyond tradition: exploring the non-canonical functions of telomeres in meiosis
title_full_unstemmed Beyond tradition: exploring the non-canonical functions of telomeres in meiosis
title_sort Beyond tradition: exploring the non-canonical functions of telomeres in meiosis
dc.creator.none.fl_str_mv Fernández-Álvarez, Alfonso
author Fernández-Álvarez, Alfonso
author_facet Fernández-Álvarez, Alfonso
author_role author
dc.contributor.none.fl_str_mv Agencia Estatal de Investigación (España)
Ministerio de Ciencia, Innovación y Universidades (España)
European Commission
Junta de Castilla y León
Consejo Superior de Investigaciones Científicas (España)
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Bouquet
Centromere
Chromosome dynamics
Gametogenesis
Meiosis
Telomeres
Yeast
topic Bouquet
Centromere
Chromosome dynamics
Gametogenesis
Meiosis
Telomeres
Yeast
description The telomere bouquet is a specific chromosomal configuration that forms during meiosis at the zygotene stage, when telomeres cluster together at the nuclear envelope. This clustering allows cytoskeleton-induced movements to be transmitted to the chromosomes, thereby facilitating homologous chromosome search and pairing. However, loss of the bouquet results in more severe meiotic defects than can be attributed solely to recombination problems, suggesting that the bouquet's full function remains elusive. Despite its transient nature and the challenges in performing in vivo analyses, information is emerging that points to a remarkable suite of non-canonical functions carried out by the bouquet. Here, we describe how new approaches in quantitative cell biology can contribute to establishing the molecular basis of the full function and plasticity of the bouquet, and thus generate a comprehensive picture of the telomeric control of meiosis.
publishDate 2023
dc.date.none.fl_str_mv 2023
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/347394
https://api.elsevier.com/content/abstract/scopus_id/85177865363
url http://hdl.handle.net/10261/347394
https://api.elsevier.com/content/abstract/scopus_id/85177865363
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/AEI//PID2021-127232NB-I00
The underlying dataset has been published as supplementary material of the article in the publisher platform at https://doi.org/10.3389/fcell.2023.1278571
https://doi.org/10.3389/fcell.2023.1278571
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
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repository.mail.fl_str_mv
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