Important abnormalities of bone mineral metabolism are present in patients with coronary artery disease with a mild decrease of the estimated glomerular filtration rate

The final publication is avilable at: Journal of Bone and Mineral Metabolism 30.9 (2015): 1-34

Detalles Bibliográficos
Autores: González Parra, Emilio José, Aceña Navarro, Álvaro, Lorenzo González, Óscar, Tarín, Nieves, González-Casaus, María Luisa, Cristóbal, Carmen, Huelmos, Ana, Mahillo, Ignacio, Pello, Ana María, Carda, Rocío, Hernández-González, Ignacio, Alonso, Joaquín, Rodríguez Artalejo, Fernando, López Bescós, Lorenzo, Ortiz Arduán, Alberto, Egido de los Ríos, Jesús, Tuñón Fernández, José Luis
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universidad Autónoma de Madrid
Repositorio:Biblos-e Archivo. Repositorio Institucional de la UAM
Idioma:inglés
OAI Identifier:oai:repositorio.uam.es:10486/671183
Acceso en línea:http://hdl.handle.net/10486/671183
https://dx.doi.org/10.1007/s00774-015-0706-y
Access Level:acceso abierto
Palabra clave:Coronary artery disease
Fibroblast growth factor 23
Glomerular filtration rate
Parathormone
Vitamin D
Medicina
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oai_identifier_str oai:repositorio.uam.es:10486/671183
network_acronym_str ES
network_name_str España
repository_id_str
dc.title.none.fl_str_mv Important abnormalities of bone mineral metabolism are present in patients with coronary artery disease with a mild decrease of the estimated glomerular filtration rate
title Important abnormalities of bone mineral metabolism are present in patients with coronary artery disease with a mild decrease of the estimated glomerular filtration rate
spellingShingle Important abnormalities of bone mineral metabolism are present in patients with coronary artery disease with a mild decrease of the estimated glomerular filtration rate
González Parra, Emilio José
Coronary artery disease
Fibroblast growth factor 23
Glomerular filtration rate
Parathormone
Vitamin D
Medicina
title_short Important abnormalities of bone mineral metabolism are present in patients with coronary artery disease with a mild decrease of the estimated glomerular filtration rate
title_full Important abnormalities of bone mineral metabolism are present in patients with coronary artery disease with a mild decrease of the estimated glomerular filtration rate
title_fullStr Important abnormalities of bone mineral metabolism are present in patients with coronary artery disease with a mild decrease of the estimated glomerular filtration rate
title_full_unstemmed Important abnormalities of bone mineral metabolism are present in patients with coronary artery disease with a mild decrease of the estimated glomerular filtration rate
title_sort Important abnormalities of bone mineral metabolism are present in patients with coronary artery disease with a mild decrease of the estimated glomerular filtration rate
dc.creator.none.fl_str_mv González Parra, Emilio José
Aceña Navarro, Álvaro
Lorenzo González, Óscar
Tarín, Nieves
González-Casaus, María Luisa
Cristóbal, Carmen
Huelmos, Ana
Mahillo, Ignacio
Pello, Ana María
Carda, Rocío
Hernández-González, Ignacio
Alonso, Joaquín
Rodríguez Artalejo, Fernando
López Bescós, Lorenzo
Ortiz Arduán, Alberto
Egido de los Ríos, Jesús
Tuñón Fernández, José Luis
author González Parra, Emilio José
author_facet González Parra, Emilio José
Aceña Navarro, Álvaro
Lorenzo González, Óscar
Tarín, Nieves
González-Casaus, María Luisa
Cristóbal, Carmen
Huelmos, Ana
Mahillo, Ignacio
Pello, Ana María
Carda, Rocío
Hernández-González, Ignacio
Alonso, Joaquín
Rodríguez Artalejo, Fernando
López Bescós, Lorenzo
Ortiz Arduán, Alberto
Egido de los Ríos, Jesús
Tuñón Fernández, José Luis
author_role author
author2 Aceña Navarro, Álvaro
Lorenzo González, Óscar
Tarín, Nieves
González-Casaus, María Luisa
Cristóbal, Carmen
Huelmos, Ana
Mahillo, Ignacio
Pello, Ana María
Carda, Rocío
Hernández-González, Ignacio
Alonso, Joaquín
Rodríguez Artalejo, Fernando
López Bescós, Lorenzo
Ortiz Arduán, Alberto
Egido de los Ríos, Jesús
Tuñón Fernández, José Luis
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Departamento de Medicina
Facultad de Medicina
Instituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)
Centro de Investigación Biomédica en Red (CIBER)
dc.subject.none.fl_str_mv Coronary artery disease
Fibroblast growth factor 23
Glomerular filtration rate
Parathormone
Vitamin D
Medicina
topic Coronary artery disease
Fibroblast growth factor 23
Glomerular filtration rate
Parathormone
Vitamin D
Medicina
description The final publication is avilable at: Journal of Bone and Mineral Metabolism 30.9 (2015): 1-34
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-08-23
dc.type.none.fl_str_mv research article
http://purl.org/coar/resource_type/c_2df8fbb1
SMUR
http://purl.org/coar/version/c_71e4c1898caa6e32
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv http://hdl.handle.net/10486/671183
https://dx.doi.org/10.1007/s00774-015-0706-y
url http://hdl.handle.net/10486/671183
https://dx.doi.org/10.1007/s00774-015-0706-y
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Springer Verlag
publisher.none.fl_str_mv Springer Verlag
dc.source.none.fl_str_mv reponame:Biblos-e Archivo. Repositorio Institucional de la UAM
instname:Universidad Autónoma de Madrid
instname_str Universidad Autónoma de Madrid
reponame_str Biblos-e Archivo. Repositorio Institucional de la UAM
collection Biblos-e Archivo. Repositorio Institucional de la UAM
repository.name.fl_str_mv
repository.mail.fl_str_mv
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spelling Important abnormalities of bone mineral metabolism are present in patients with coronary artery disease with a mild decrease of the estimated glomerular filtration rateGonzález Parra, Emilio JoséAceña Navarro, ÁlvaroLorenzo González, ÓscarTarín, NievesGonzález-Casaus, María LuisaCristóbal, CarmenHuelmos, AnaMahillo, IgnacioPello, Ana MaríaCarda, RocíoHernández-González, IgnacioAlonso, JoaquínRodríguez Artalejo, FernandoLópez Bescós, LorenzoOrtiz Arduán, AlbertoEgido de los Ríos, JesúsTuñón Fernández, José LuisCoronary artery diseaseFibroblast growth factor 23Glomerular filtration rateParathormoneVitamin DMedicinaThe final publication is avilable at: Journal of Bone and Mineral Metabolism 30.9 (2015): 1-34Chronic kidney disease (CKD)–mineral and bone disorder (MBD) is characterized by increased circulating levels of parathormone (PTH) and fibroblast growth factor 23 (FGF23), bone disease, and vascular calcification, and is associated with adverse outcomes. We studied the prevalence of mineral metabolism disorders, and the potential relationship between decreased estimated glomerular filtration rate (eGFR) and CKD-MBD in coronary artery disease patients in a cross-sectional study of 704 outpatients 7.5 ± 3.0 months after an acute coronary syndrome. The mean eGFR (CKD Epidemiology Collaboration formula) was 75.8 ± 19.1 ml/min/1.73 m2. Our patients showed lower calcidiol plasma levels than a healthy cohort from the same geographical area. In the case of men, this finding was present despite similar creatinine levels in both groups and older age of the healthy subjects. Most patients (75.6 %) had an eGFR below 90 ml/min/1.73 m2 (eGFR categories G2–G5), with 55.3 % of patients exhibiting values of 60–89 ml/min/1.73 m2 (G2). PTH (r = −0.3329, p < 0.0001) and FGF23 (r = −0.3641, p < 0.0001) levels inversely correlated with eGFR, whereas calcidiol levels and serum phosphate levels did not. Overall, PTH levels were above normal in 34.9 % of patients. This proportion increased from 19.4 % in G1 category patients, to 33.7 % in G2 category patients and 56.6 % in G3–G5 category patients (p < 0.001). In multivariate analysis, eGFR and calcidiol levels were the main independent determinants of serum PTH. The mean FGF23 levels were 69.9 (54.6–96.2) relative units (RU)/ml, and 33.2 % of patients had FGF23 levels above 85.5 RU/ml (18.4 % in G1 category patients, 30.0 % in G2 category patients, and 59.2 % in G3–G5 category patients; p < 0.001). In multivariate analysis, eGFR was the main predictor of FGF23 levels. Increased phosphate levels were present in 0.7 % of the whole sample: 0 % in G1 category patients, 0.3 % in G2 category patients, and 2.8 % in G3–G5 category patients (p = 0.011). Almost 90 % of patients had calcidiol insufficiency without significant differences among the different degrees of eGFR. In conclusion, in patients with coronary artery disease there is a large prevalence of increased FGF23 and PTH levels. These findings have an independent relationship with decreased eGFR, and are evident at an eGFR of 60–89 ml/min/1.73 m2. Then, mild decreases in eGFR must be taken in consideration by the clinician because they are associated with progressive abnormalities of mineral metabolismFondo de Investigaciones Sanitarias (PI10/00072, PI14/00386, PIE13/00051, PI05/0451, PI05/1497, PI05/52475, PI05/1043, PS09/01405, PI14/1567) y FRIAT, Spanish Society of Cardiology, Spanish Heart Foundation, Spanish Society of Arteriosclerosis, REDINREN (RD012/0021), Biobank grants from Instituto de Salud Carlos III FEDER, RD09/0076/00101 (FJD Biobank) and Abbvie Laboratories. PN I+D+I 2008-2011 and ISCIII co-financed by FEDER, CIBERDEM and e-PREDICESpringer VerlagDepartamento de MedicinaFacultad de MedicinaInstituto de Investigación Sanitaria Fundación Jiménez Díaz (IIS-FJD)Centro de Investigación Biomédica en Red (CIBER)20152015-08-23research articlehttp://purl.org/coar/resource_type/c_2df8fbb1SMURhttp://purl.org/coar/version/c_71e4c1898caa6e32info:eu-repo/semantics/articleapplication/pdfhttp://hdl.handle.net/10486/671183https://dx.doi.org/10.1007/s00774-015-0706-yreponame:Biblos-e Archivo. Repositorio Institucional de la UAMinstname:Universidad Autónoma de MadridInglésengopen accesshttp://purl.org/coar/access_right/c_abf2info:eu-repo/semantics/openAccessoai:repositorio.uam.es:10486/6711832026-06-23T12:46:27Z
score 15,301603

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