Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targets

Ticks act as vectors of pathogens affecting human and animal health worldwide, and recent research has focused on the characterization of tick-pathogen interactions using omics technologies to identify new targets for developing novel control interventions. The regulome (transcription factors-target...

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Autores: Artigas-Jerónimo, Sara, Estrada-Peña, Agustín, Cabezas-Cruz, Alejandro, Alberdi, Pilar, Villar, Margarita, Fuente, José de la
Formato: artículo
Estado:Versión publicada
Fecha de publicación:2019
País:España
Recursos:Consejo Superior de Investigaciones Científicas (CSIC)
Repositorio:DIGITAL.CSIC. Repositorio Institucional del CSIC
OAI Identifier:oai:digital.csic.es:10261/215880
Acesso em linha:http://hdl.handle.net/10261/215880
Access Level:acceso abierto
Palavra-chave:Regulome
Transcription
Tick
Ixodes scapularis
Anaplasma phagocytophilum
ISE6 cells
id ES_7affef67ad4b7a34330f3b5489869e7e
oai_identifier_str oai:digital.csic.es:10261/215880
network_acronym_str ES
network_name_str España
repository_id_str
spelling Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targetsArtigas-Jerónimo, SaraEstrada-Peña, AgustínCabezas-Cruz, AlejandroAlberdi, PilarVillar, MargaritaFuente, José de laRegulomeTranscriptionTickIxodes scapularisAnaplasma phagocytophilumISE6 cellsTicks act as vectors of pathogens affecting human and animal health worldwide, and recent research has focused on the characterization of tick-pathogen interactions using omics technologies to identify new targets for developing novel control interventions. The regulome (transcription factors-target genes interactions) plays a critical role in cell response to pathogen infection. Therefore, the application of regulomics to tick-pathogen interactions would advance our understanding of these molecular interactions and contribute to the identification of novel control targets for the prevention and control of tick infestations and tick-borne diseases. However, limited information is available on the role of tick regulome in response to pathogen infection. In this study, we applied complementary in silico approaches to modeling how Anaplasma phagocytophilum infection modulates tick vector regulome. This proof-of-concept research provided support for the use of network analysis in the study of regulome response to infection, resulting in new information on tick-pathogen interactions and potential targets for developing interventions for the control of tick infestations and pathogen transmission. Deciphering the precise nature of circuits that shape the tick regulome in response to pathogen infection is an area of research that in the future will advance our knowledge of tick-pathogen interactions, and the identification of new antigens for the control of tick infestations and pathogen infection/transmission.This research was financially supported by the Ministerio de Economía, Industria y Competitividad, Spain grant BFU2016-79892-P. MV was funded by the Universidad de Castilla La Mancha, Spain.Peer reviewedFrontiers MediaMinisterio de Economía y Competitividad (España)Ministerio de Economía, Industria y Competitividad (España)Universidad de Castilla La ManchaConsejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]202020202019info:eu-repo/semantics/articlehttp://purl.org/coar/resource_type/c_6501Publisher's versioninfo:eu-repo/semantics/publishedVersionhttp://hdl.handle.net/10261/215880reponame:DIGITAL.CSIC. Repositorio Institucional del CSICinstname:Consejo Superior de Investigaciones Científicas (CSIC)Inglés#PLACEHOLDER_PARENT_METADATA_VALUE#info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-79892-Phttps://doi.org/10.3389/fphys.2019.00462Síinfo:eu-repo/semantics/openAccessoai:digital.csic.es:10261/2158802026-05-22T06:33:51Z
dc.title.none.fl_str_mv Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targets
title Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targets
spellingShingle Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targets
Artigas-Jerónimo, Sara
Regulome
Transcription
Tick
Ixodes scapularis
Anaplasma phagocytophilum
ISE6 cells
title_short Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targets
title_full Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targets
title_fullStr Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targets
title_full_unstemmed Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targets
title_sort Modeling modulation of the tick regulome in response to Anaplasma phagocytophilum for the identification of new control targets
dc.creator.none.fl_str_mv Artigas-Jerónimo, Sara
Estrada-Peña, Agustín
Cabezas-Cruz, Alejandro
Alberdi, Pilar
Villar, Margarita
Fuente, José de la
author Artigas-Jerónimo, Sara
author_facet Artigas-Jerónimo, Sara
Estrada-Peña, Agustín
Cabezas-Cruz, Alejandro
Alberdi, Pilar
Villar, Margarita
Fuente, José de la
author_role author
author2 Estrada-Peña, Agustín
Cabezas-Cruz, Alejandro
Alberdi, Pilar
Villar, Margarita
Fuente, José de la
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Ministerio de Economía y Competitividad (España)
Ministerio de Economía, Industria y Competitividad (España)
Universidad de Castilla La Mancha
Consejo Superior de Investigaciones Científicas [https://ror.org/02gfc7t72]
dc.subject.none.fl_str_mv Regulome
Transcription
Tick
Ixodes scapularis
Anaplasma phagocytophilum
ISE6 cells
topic Regulome
Transcription
Tick
Ixodes scapularis
Anaplasma phagocytophilum
ISE6 cells
description Ticks act as vectors of pathogens affecting human and animal health worldwide, and recent research has focused on the characterization of tick-pathogen interactions using omics technologies to identify new targets for developing novel control interventions. The regulome (transcription factors-target genes interactions) plays a critical role in cell response to pathogen infection. Therefore, the application of regulomics to tick-pathogen interactions would advance our understanding of these molecular interactions and contribute to the identification of novel control targets for the prevention and control of tick infestations and tick-borne diseases. However, limited information is available on the role of tick regulome in response to pathogen infection. In this study, we applied complementary in silico approaches to modeling how Anaplasma phagocytophilum infection modulates tick vector regulome. This proof-of-concept research provided support for the use of network analysis in the study of regulome response to infection, resulting in new information on tick-pathogen interactions and potential targets for developing interventions for the control of tick infestations and pathogen transmission. Deciphering the precise nature of circuits that shape the tick regulome in response to pathogen infection is an area of research that in the future will advance our knowledge of tick-pathogen interactions, and the identification of new antigens for the control of tick infestations and pathogen infection/transmission.
publishDate 2019
dc.date.none.fl_str_mv 2019
2020
2020
dc.type.none.fl_str_mv info:eu-repo/semantics/article
http://purl.org/coar/resource_type/c_6501
Publisher's version
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/10261/215880
url http://hdl.handle.net/10261/215880
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv #PLACEHOLDER_PARENT_METADATA_VALUE#
info:eu-repo/grantAgreement/MINECO/Plan Estatal de Investigación Científica y Técnica y de Innovación 2013-2016/BFU2016-79892-P
https://doi.org/10.3389/fphys.2019.00462
Sí
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:DIGITAL.CSIC. Repositorio Institucional del CSIC
instname:Consejo Superior de Investigaciones Científicas (CSIC)
instname_str Consejo Superior de Investigaciones Científicas (CSIC)
reponame_str DIGITAL.CSIC. Repositorio Institucional del CSIC
collection DIGITAL.CSIC. Repositorio Institucional del CSIC
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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