Screening of virulence genes in Staphylococcus aureus isolates from rabbits

[EN] Staphylococcus aureus is a versatile pathogen able to cause disease in both humans and animals. In rabbits, this bacterium infects animals of different ages, producing several purulent lesions. The ability of S. aureus to cause disease depends on a combination of virulence factors. The aim of t...

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Detalles Bibliográficos
Autores: Viana Martín, David, Selva, Laura, Penadés, Mariola, Corpa, Juan Manuel
Tipo de recurso: artículo
Fecha de publicación:2015
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/58961
Acceso en línea:https://riunet.upv.es/handle/10251/58961
Access Level:acceso abierto
Palabra clave:Staphylococcus aureus
Rabbit
Virulence factors
Genotype
MLST
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spelling Screening of virulence genes in Staphylococcus aureus isolates from rabbitsViana Martín, DavidSelva, LauraPenadés, MariolaCorpa, Juan ManuelStaphylococcus aureusRabbitVirulence factorsGenotypeMLST[EN] Staphylococcus aureus is a versatile pathogen able to cause disease in both humans and animals. In rabbits, this bacterium infects animals of different ages, producing several purulent lesions. The ability of S. aureus to cause disease depends on a combination of virulence factors. The aim of this study was therefore to investigate the distribution of bacterial virulence determinants in 69 S. aureus isolates from rabbits. Some virulence factors (7 adhesins, 1 toxin and 1 protease) were positive in all rabbit S. aureus isolates analysed, while others (1 adhesin and 10 toxins) were always negative. The remaining virulence factors were more variable among isolates. An association between genotype and the different profiles of virulence factors was observed, but not with the type of lesion (P<0.05). One strain of each genotype was further analysed by multilocus sequence typing, generating ST121, ST96 and ST2951, determining a greater number of enterotoxins in ST121 isolates compared to ST96 and ST2951 isolates, which could justify the different pathogenicity between strains. This study was supported by the Inter-ministerial Commission for Science and Technology (CICYT) of the Spanish Government (AGL2011-30170-C02-02 and AGL2014-53405-C2-2-P). The fellowship support for MP from Ministry of Education, Culture and Sports, Spain (AP2010-3907) is gratefully acknowledged.Editorial Universitat Politècnica de ValènciaMinisterio de Educación, Cultura y DeporteMinisterio de Ciencia e InnovaciónMinisterio de Economía y CompetitividadRepositorio Institucional de la Universitat Politècnica de València Riunet20152015-09-30journal articlehttp://purl.org/coar/resource_type/c_6501VoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://riunet.upv.es/handle/10251/58961reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valénciainstname:Universitat Politècnica de València (UPV)InglésengMinisterio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 AGL2011-30170-C02-02 ESTUDIO DEL SISTEMA INMUNE DE DIFERENTES LINEAS GENETICAS CUNICOLAS Y SU RESPUESTA FRENTE A DESAFIOS PRODUCTIVOS E INFECCIOSOSMinisterio de Educación y Cultura http://dx.doi.org/10.13039/501100003176 AP2010-3907 AP2010-3907Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 AGL2014-53405-C2-2-P CARACTERIZACION INMUNOLOGICA Y RESPUESTA INMUNE A RETOS INFECCIOSOS EN CONEJOS SEPARADOS POR 15 AÑOS DE SELECCION POR TASA DE CRECIMIENTOopen accesshttp://purl.org/coar/access_right/c_abf2Reserva de todos los derechoshttp://rightsstatements.org/vocab/InC/1.0/info:eu-repo/semantics/openAccessoai:riunet.upv.es:10251/589612026-06-13T07:49:27Z
dc.title.none.fl_str_mv Screening of virulence genes in Staphylococcus aureus isolates from rabbits
title Screening of virulence genes in Staphylococcus aureus isolates from rabbits
spellingShingle Screening of virulence genes in Staphylococcus aureus isolates from rabbits
Viana Martín, David
Staphylococcus aureus
Rabbit
Virulence factors
Genotype
MLST
title_short Screening of virulence genes in Staphylococcus aureus isolates from rabbits
title_full Screening of virulence genes in Staphylococcus aureus isolates from rabbits
title_fullStr Screening of virulence genes in Staphylococcus aureus isolates from rabbits
title_full_unstemmed Screening of virulence genes in Staphylococcus aureus isolates from rabbits
title_sort Screening of virulence genes in Staphylococcus aureus isolates from rabbits
dc.creator.none.fl_str_mv Viana Martín, David
Selva, Laura
Penadés, Mariola
Corpa, Juan Manuel
author Viana Martín, David
author_facet Viana Martín, David
Selva, Laura
Penadés, Mariola
Corpa, Juan Manuel
author_role author
author2 Selva, Laura
Penadés, Mariola
Corpa, Juan Manuel
author2_role author
author
author
dc.contributor.none.fl_str_mv Ministerio de Educación, Cultura y Deporte
Ministerio de Ciencia e Innovación
Ministerio de Economía y Competitividad
Repositorio Institucional de la Universitat Politècnica de València Riunet
dc.subject.none.fl_str_mv Staphylococcus aureus
Rabbit
Virulence factors
Genotype
MLST
topic Staphylococcus aureus
Rabbit
Virulence factors
Genotype
MLST
description [EN] Staphylococcus aureus is a versatile pathogen able to cause disease in both humans and animals. In rabbits, this bacterium infects animals of different ages, producing several purulent lesions. The ability of S. aureus to cause disease depends on a combination of virulence factors. The aim of this study was therefore to investigate the distribution of bacterial virulence determinants in 69 S. aureus isolates from rabbits. Some virulence factors (7 adhesins, 1 toxin and 1 protease) were positive in all rabbit S. aureus isolates analysed, while others (1 adhesin and 10 toxins) were always negative. The remaining virulence factors were more variable among isolates. An association between genotype and the different profiles of virulence factors was observed, but not with the type of lesion (P<0.05). One strain of each genotype was further analysed by multilocus sequence typing, generating ST121, ST96 and ST2951, determining a greater number of enterotoxins in ST121 isolates compared to ST96 and ST2951 isolates, which could justify the different pathogenicity between strains. 
publishDate 2015
dc.date.none.fl_str_mv 2015
2015-09-30
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://riunet.upv.es/handle/10251/58961
url https://riunet.upv.es/handle/10251/58961
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.relation.none.fl_str_mv Ministerio de Ciencia e Innovación http://dx.doi.org/10.13039/501100004837 AGL2011-30170-C02-02 ESTUDIO DEL SISTEMA INMUNE DE DIFERENTES LINEAS GENETICAS CUNICOLAS Y SU RESPUESTA FRENTE A DESAFIOS PRODUCTIVOS E INFECCIOSOS
Ministerio de Educación y Cultura http://dx.doi.org/10.13039/501100003176 AP2010-3907 AP2010-3907
Ministerio de Economía y Competitividad http://dx.doi.org/10.13039/501100003329 AGL2014-53405-C2-2-P CARACTERIZACION INMUNOLOGICA Y RESPUESTA INMUNE A RETOS INFECCIOSOS EN CONEJOS SEPARADOS POR 15 AÑOS DE SELECCION POR TASA DE CRECIMIENTO
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Reserva de todos los derechos
http://rightsstatements.org/vocab/InC/1.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Editorial Universitat Politècnica de València
publisher.none.fl_str_mv Editorial Universitat Politècnica de València
dc.source.none.fl_str_mv reponame:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
instname:Universitat Politècnica de València (UPV)
instname_str Universitat Politècnica de València (UPV)
reponame_str RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
collection RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
repository.name.fl_str_mv
repository.mail.fl_str_mv
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