Gastrin treatment stimulates beta cell regeneration and improves glucose tolerance in 95% pancreatectomized rats

β-Cell mass reduction is a central aspect in the development of type 1 and type 2 diabetes, and substitution or regeneration of the lost β-cells is a potentially curative treatment of diabetes. To study the effects of gastrin on β-cell mass in rats with 95% pancreatectomy (95%-Px), a model of pancre...

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Autores: Téllez i Besolí, Noèlia, Joanny Ordóñez, Géraldine, Escoriza, Jessica, Vilaseca Barceló, Marina, Montanya Mias, Eduard
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2011
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/134421
Acceso en línea:https://hdl.handle.net/2445/134421
Access Level:acceso abierto
Palabra clave:Gastrina
Cèl·lules B
Glucosa
Tolerància
Ús terapèutic
Gastrin
B cells
Glucose
Toleration
Therapeutic use
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spelling Gastrin treatment stimulates beta cell regeneration and improves glucose tolerance in 95% pancreatectomized ratsTéllez i Besolí, NoèliaJoanny Ordóñez, GéraldineEscoriza, JessicaVilaseca Barceló, MarinaMontanya Mias, EduardGastrinaCèl·lules BGlucosaTolerànciaÚs terapèuticGastrinB cellsGlucoseTolerationTherapeutic useβ-Cell mass reduction is a central aspect in the development of type 1 and type 2 diabetes, and substitution or regeneration of the lost β-cells is a potentially curative treatment of diabetes. To study the effects of gastrin on β-cell mass in rats with 95% pancreatectomy (95%-Px), a model of pancreatic regeneration, rats underwent 95% Px or sham Px and were treated with [15 leu] gastrin-17 (Px+G and S+G) or vehicle (Px+V and S+V) for 15 d. In 95% Px rats, gastrin treatment reduced hyperglycemia (280 ± 52 mg vs. 436 ± 51 mg/dl, P < 0.05), and increased β-cell mass (1.15 ± 0.15 mg)) compared with vehicle-treated rats (0.67 ± 0.15 mg, P < 0.05). Gastrin treatment induced β-cell regeneration by enhancing β-cell neogenesis (increased number of extraislet β-cells in Px+G: 0.42 ± 0.05 cells/mm(2) vs. Px+V: 0.27 ± 0.07 cells/mm(2), P < 0.05, and pancreatic and duodenal homeobox 1 expression in ductal cells of Px+G: 1.21 ± 0.38% vs. Px+V: 0.23 ± 0.10%, P < 0.05) and replication (Px+G: 1.65 ± 0.26% vs. S+V: 0.64 ± 0.14%; P < 0.05). In addition, reduced β-cell apoptosis contributed to the increased β-cell mass in gastrin-treated rats (Px+G: 0.07 ± 0.02%, Px+V: 0.23 ± 0.05%; P < 0.05). Gastrin action on β-cell regeneration and survival increased β-cell mass and improved glucose tolerance in 95% Px rats, supporting a potential role of gastrin in the treatment of diabetes.Association for the Study of Internal Secretions2019201920112019info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion9 p.application/pdfapplication/pdfhttps://hdl.handle.net/2445/134421Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1210/en.2011-0066Endocrinology, 2011, vol. 152, num. 7, p. 2580-2588https://doi.org/10.1210/en.2011-0066(c) Association for the Study of Internal Secretions, 2011info:eu-repo/semantics/openAccessoai:recercat.cat:2445/1344212026-05-29T05:05:01Z
dc.title.none.fl_str_mv Gastrin treatment stimulates beta cell regeneration and improves glucose tolerance in 95% pancreatectomized rats
title Gastrin treatment stimulates beta cell regeneration and improves glucose tolerance in 95% pancreatectomized rats
spellingShingle Gastrin treatment stimulates beta cell regeneration and improves glucose tolerance in 95% pancreatectomized rats
Téllez i Besolí, Noèlia
Gastrina
Cèl·lules B
Glucosa
Tolerància
Ús terapèutic
Gastrin
B cells
Glucose
Toleration
Therapeutic use
title_short Gastrin treatment stimulates beta cell regeneration and improves glucose tolerance in 95% pancreatectomized rats
title_full Gastrin treatment stimulates beta cell regeneration and improves glucose tolerance in 95% pancreatectomized rats
title_fullStr Gastrin treatment stimulates beta cell regeneration and improves glucose tolerance in 95% pancreatectomized rats
title_full_unstemmed Gastrin treatment stimulates beta cell regeneration and improves glucose tolerance in 95% pancreatectomized rats
title_sort Gastrin treatment stimulates beta cell regeneration and improves glucose tolerance in 95% pancreatectomized rats
dc.creator.none.fl_str_mv Téllez i Besolí, Noèlia
Joanny Ordóñez, Géraldine
Escoriza, Jessica
Vilaseca Barceló, Marina
Montanya Mias, Eduard
author Téllez i Besolí, Noèlia
author_facet Téllez i Besolí, Noèlia
Joanny Ordóñez, Géraldine
Escoriza, Jessica
Vilaseca Barceló, Marina
Montanya Mias, Eduard
author_role author
author2 Joanny Ordóñez, Géraldine
Escoriza, Jessica
Vilaseca Barceló, Marina
Montanya Mias, Eduard
author2_role author
author
author
author
dc.subject.none.fl_str_mv Gastrina
Cèl·lules B
Glucosa
Tolerància
Ús terapèutic
Gastrin
B cells
Glucose
Toleration
Therapeutic use
topic Gastrina
Cèl·lules B
Glucosa
Tolerància
Ús terapèutic
Gastrin
B cells
Glucose
Toleration
Therapeutic use
description β-Cell mass reduction is a central aspect in the development of type 1 and type 2 diabetes, and substitution or regeneration of the lost β-cells is a potentially curative treatment of diabetes. To study the effects of gastrin on β-cell mass in rats with 95% pancreatectomy (95%-Px), a model of pancreatic regeneration, rats underwent 95% Px or sham Px and were treated with [15 leu] gastrin-17 (Px+G and S+G) or vehicle (Px+V and S+V) for 15 d. In 95% Px rats, gastrin treatment reduced hyperglycemia (280 ± 52 mg vs. 436 ± 51 mg/dl, P < 0.05), and increased β-cell mass (1.15 ± 0.15 mg)) compared with vehicle-treated rats (0.67 ± 0.15 mg, P < 0.05). Gastrin treatment induced β-cell regeneration by enhancing β-cell neogenesis (increased number of extraislet β-cells in Px+G: 0.42 ± 0.05 cells/mm(2) vs. Px+V: 0.27 ± 0.07 cells/mm(2), P < 0.05, and pancreatic and duodenal homeobox 1 expression in ductal cells of Px+G: 1.21 ± 0.38% vs. Px+V: 0.23 ± 0.10%, P < 0.05) and replication (Px+G: 1.65 ± 0.26% vs. S+V: 0.64 ± 0.14%; P < 0.05). In addition, reduced β-cell apoptosis contributed to the increased β-cell mass in gastrin-treated rats (Px+G: 0.07 ± 0.02%, Px+V: 0.23 ± 0.05%; P < 0.05). Gastrin action on β-cell regeneration and survival increased β-cell mass and improved glucose tolerance in 95% Px rats, supporting a potential role of gastrin in the treatment of diabetes.
publishDate 2011
dc.date.none.fl_str_mv 2011
2019
2019
2019
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/134421
url https://hdl.handle.net/2445/134421
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1210/en.2011-0066
Endocrinology, 2011, vol. 152, num. 7, p. 2580-2588
https://doi.org/10.1210/en.2011-0066
dc.rights.none.fl_str_mv (c) Association for the Study of Internal Secretions, 2011
info:eu-repo/semantics/openAccess
rights_invalid_str_mv (c) Association for the Study of Internal Secretions, 2011
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 9 p.
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Association for the Study of Internal Secretions
publisher.none.fl_str_mv Association for the Study of Internal Secretions
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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