Allogeneic Hematopoietic Stem Cell Transplantation in Transformed Follicular Lymphoma (tFL): Results of a Retrospective Multicenter Study from GELTAMO/GETH-TC Spanish Groups.

Rey-Bua, Beatriz; Cabrero, Monica; Bento, Leyre; Montoro, Juan; Bastos-Oreiro, Mariana; Parody, Rocio; Yanez, Lucrecia; Lopez-Godino, Oriana; Zanabili, Joud; Herrera, Pilar; Gutierrez, Gonzalo; Perez, Ariadna; Pinana, Jose L; Novelli, Silvana; Cortes, Maria; Sureda, Ana Maria; Caballero, Dolores; Garcia-Sancho, Alejandro Martin

Allogeneic Hematopoietic Stem Cell Transplantation in Transformed Follicular Lymphoma (tFL): Results of a Retrospective Multicenter Study from GELTAMO/GETH-TC Spanish Groups.

BACKGROUND: Transformation of follicular lymphoma into an aggressive lymphoma (tFL) worsens the prognosis and the standard treatment is not completely defined. Allogeneic hematopoietic stem cell transplantation (alloSCT) could be a potentially curative option for these patients, but it has not been...

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Detalhes bibliográficos
Autores:	Rey-Bua, Beatriz, Cabrero, Monica, Bento, Leyre, Montoro, Juan, Bastos-Oreiro, Mariana, Parody, Rocio, Yanez, Lucrecia, Lopez-Godino, Oriana, Zanabili, Joud, Herrera, Pilar, Gutierrez, Gonzalo, Perez, Ariadna, Pinana, Jose L, Novelli, Silvana, Cortes, Maria, Sureda, Ana Maria, Caballero, Dolores, Garcia-Sancho, Alejandro Martin
Formato:	artículo
Estado:	Versión publicada
Fecha de publicación:	2022
País:	España
Recursos:	INCLIVA
Repositorio:	r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
OAI Identifier:	oai:incliva.fundanetsuite.com:p17028
Acesso em linha:	https://incliva.portalinvestigacion.com/publicaciones/17028
Access Level:	acceso abierto
Palavra-chave:	allogeneic stem cell transplantation follicular lymphoma non-Hodgkin lymphoma transformed lymphoma

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spelling	Allogeneic Hematopoietic Stem Cell Transplantation in Transformed Follicular Lymphoma (tFL): Results of a Retrospective Multicenter Study from GELTAMO/GETH-TC Spanish Groups.Rey-Bua, BeatrizCabrero, MonicaBento, LeyreMontoro, JuanBastos-Oreiro, MarianaParody, RocioYanez, LucreciaLopez-Godino, OrianaZanabili, JoudHerrera, PilarGutierrez, GonzaloPerez, AriadnaPinana, Jose LNovelli, SilvanaCortes, MariaSureda, Ana MariaCaballero, DoloresGarcia-Sancho, Alejandro Martinallogeneic stem cell transplantationfollicular lymphomanon-Hodgkin lymphomatransformed lymphomaBACKGROUND: Transformation of follicular lymphoma into an aggressive lymphoma (tFL) worsens the prognosis and the standard treatment is not completely defined. Allogeneic hematopoietic stem cell transplantation (alloSCT) could be a potentially curative option for these patients, but it has not been widely explored. METHODS: We designed a retrospective multicenter study to analyze the efficacy and toxicity of alloSCT in tFL patients and potential prognostic factors of survival. RESULTS: A total of 43 patients diagnosed with tFL who underwent alloSCT in 14 Spanish centers between January 2000 and January 2019 were included. Median age was 44 (31-67) years. After a median follow-up of 58 months, estimated 5-year overall survival (OS) and progression-free survival (PFS) were both 35%. Estimated 100-day and 1-year non-relapse mortality (NRM) were 20% and 34%, respectively. The type of conditioning regimen (3-year OS of 52% vs. 20%, respectively, for reduced-intensity vs. myeloablative conditioning) and development of chronic graft versus host disease (cGVHD) (3-year OS of 75% vs. 40%) were the only factors significantly associated with OS. The only variable with an independent association with OS was cGVHD (HR, 3.4; 95% CI, 1.2-9.6). CONCLUSIONS: Our results indicate that alloSCT continues to be a potentially curative option for patients with tFL.MDPI2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://incliva.portalinvestigacion.com/publicaciones/17028CancersISSN: 20726694reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVAinstname:INCLIVAInglésinfo:eu-repo/semantics/openAccessoai:incliva.fundanetsuite.com:p170282026-06-07T16:35:31Z
dc.title.none.fl_str_mv	Allogeneic Hematopoietic Stem Cell Transplantation in Transformed Follicular Lymphoma (tFL): Results of a Retrospective Multicenter Study from GELTAMO/GETH-TC Spanish Groups.
title	Allogeneic Hematopoietic Stem Cell Transplantation in Transformed Follicular Lymphoma (tFL): Results of a Retrospective Multicenter Study from GELTAMO/GETH-TC Spanish Groups.
spellingShingle	Allogeneic Hematopoietic Stem Cell Transplantation in Transformed Follicular Lymphoma (tFL): Results of a Retrospective Multicenter Study from GELTAMO/GETH-TC Spanish Groups. Rey-Bua, Beatriz allogeneic stem cell transplantation follicular lymphoma non-Hodgkin lymphoma transformed lymphoma
title_short	Allogeneic Hematopoietic Stem Cell Transplantation in Transformed Follicular Lymphoma (tFL): Results of a Retrospective Multicenter Study from GELTAMO/GETH-TC Spanish Groups.
title_full	Allogeneic Hematopoietic Stem Cell Transplantation in Transformed Follicular Lymphoma (tFL): Results of a Retrospective Multicenter Study from GELTAMO/GETH-TC Spanish Groups.
title_fullStr	Allogeneic Hematopoietic Stem Cell Transplantation in Transformed Follicular Lymphoma (tFL): Results of a Retrospective Multicenter Study from GELTAMO/GETH-TC Spanish Groups.
title_full_unstemmed	Allogeneic Hematopoietic Stem Cell Transplantation in Transformed Follicular Lymphoma (tFL): Results of a Retrospective Multicenter Study from GELTAMO/GETH-TC Spanish Groups.
title_sort	Allogeneic Hematopoietic Stem Cell Transplantation in Transformed Follicular Lymphoma (tFL): Results of a Retrospective Multicenter Study from GELTAMO/GETH-TC Spanish Groups.
dc.creator.none.fl_str_mv	Rey-Bua, Beatriz Cabrero, Monica Bento, Leyre Montoro, Juan Bastos-Oreiro, Mariana Parody, Rocio Yanez, Lucrecia Lopez-Godino, Oriana Zanabili, Joud Herrera, Pilar Gutierrez, Gonzalo Perez, Ariadna Pinana, Jose L Novelli, Silvana Cortes, Maria Sureda, Ana Maria Caballero, Dolores Garcia-Sancho, Alejandro Martin
author	Rey-Bua, Beatriz
author_facet	Rey-Bua, Beatriz Cabrero, Monica Bento, Leyre Montoro, Juan Bastos-Oreiro, Mariana Parody, Rocio Yanez, Lucrecia Lopez-Godino, Oriana Zanabili, Joud Herrera, Pilar Gutierrez, Gonzalo Perez, Ariadna Pinana, Jose L Novelli, Silvana Cortes, Maria Sureda, Ana Maria Caballero, Dolores Garcia-Sancho, Alejandro Martin
author_role	author
author2	Cabrero, Monica Bento, Leyre Montoro, Juan Bastos-Oreiro, Mariana Parody, Rocio Yanez, Lucrecia Lopez-Godino, Oriana Zanabili, Joud Herrera, Pilar Gutierrez, Gonzalo Perez, Ariadna Pinana, Jose L Novelli, Silvana Cortes, Maria Sureda, Ana Maria Caballero, Dolores Garcia-Sancho, Alejandro Martin
author2_role	author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	allogeneic stem cell transplantation follicular lymphoma non-Hodgkin lymphoma transformed lymphoma
topic	allogeneic stem cell transplantation follicular lymphoma non-Hodgkin lymphoma transformed lymphoma
description	BACKGROUND: Transformation of follicular lymphoma into an aggressive lymphoma (tFL) worsens the prognosis and the standard treatment is not completely defined. Allogeneic hematopoietic stem cell transplantation (alloSCT) could be a potentially curative option for these patients, but it has not been widely explored. METHODS: We designed a retrospective multicenter study to analyze the efficacy and toxicity of alloSCT in tFL patients and potential prognostic factors of survival. RESULTS: A total of 43 patients diagnosed with tFL who underwent alloSCT in 14 Spanish centers between January 2000 and January 2019 were included. Median age was 44 (31-67) years. After a median follow-up of 58 months, estimated 5-year overall survival (OS) and progression-free survival (PFS) were both 35%. Estimated 100-day and 1-year non-relapse mortality (NRM) were 20% and 34%, respectively. The type of conditioning regimen (3-year OS of 52% vs. 20%, respectively, for reduced-intensity vs. myeloablative conditioning) and development of chronic graft versus host disease (cGVHD) (3-year OS of 75% vs. 40%) were the only factors significantly associated with OS. The only variable with an independent association with OS was cGVHD (HR, 3.4; 95% CI, 1.2-9.6). CONCLUSIONS: Our results indicate that alloSCT continues to be a potentially curative option for patients with tFL.
publishDate	2022
dc.date.none.fl_str_mv	2022
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://incliva.portalinvestigacion.com/publicaciones/17028
url	https://incliva.portalinvestigacion.com/publicaciones/17028
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	MDPI
publisher.none.fl_str_mv	MDPI
dc.source.none.fl_str_mv	Cancers ISSN: 20726694 reponame:r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA instname:INCLIVA
instname_str	INCLIVA
reponame_str	r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
collection	r-INCLIVA. Repositorio Institucional de Producción Científica de INCLIVA
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score	15,81155

Allogeneic Hematopoietic Stem Cell Transplantation in Transformed Follicular Lymphoma (tFL): Results of a Retrospective Multicenter Study from GELTAMO/GETH-TC Spanish Groups.

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