miRNA nanoencapsulation to regulate the programming of the blood-brain barrier permeability by hipoxia.

Central nervous system (CNS)-related diseases are difficult to treat as most therapeutic agents they cannot reach the brain tissue, mainly due to the blood-brain barrier (BBB), arguably the tightest barrier between the human body and cerebral parenchyma, which routinely excludes most xenobiotic ther...

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Detalles Bibliográficos
Autores: Figueroa Becerra, Esteban, Caballero Roman, Aitor, Ticó Grau, Josep R., Miñarro Carmona, Montserrat, Nardi Ricart, Anna, González Candia, Alejandro
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2022
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/208726
Acceso en línea:https://hdl.handle.net/2445/208726
Access Level:acceso abierto
Palabra clave:Micro RNAs
Anoxèmia
MicroRNAs
Anoxemia
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spelling miRNA nanoencapsulation to regulate the programming of the blood-brain barrier permeability by hipoxia.Figueroa Becerra, EstebanCaballero Roman, AitorTicó Grau, Josep R.Miñarro Carmona, MontserratNardi Ricart, AnnaGonzález Candia, AlejandroMicro RNAsAnoxèmiaMicroRNAsAnoxemiaCentral nervous system (CNS)-related diseases are difficult to treat as most therapeutic agents they cannot reach the brain tissue, mainly due to the blood-brain barrier (BBB), arguably the tightest barrier between the human body and cerebral parenchyma, which routinely excludes most xenobiotic therapeutics compounds. The BBB is a multicellular complex that structurally forms the neurovascular unit (NVU) and is organized by neuro-endothelial and glial cells. BBB breakdown and dysfunction from the cerebrovascular cells lead to leakages of systemic components from the blood into the CNS, contributing to neurological deficits. Understanding the molecular mechanisms that regulate BBB permeability and disruption is essential for establishing future therapeutic strategies to restore permeability and improve cerebrovascular health. MicroRNAs (miRNAs), a type of small noncoding RNAs, are emerging as an important regulator of BBB integrity by modulating gene expression by targeting mRNA transcripts. miRNAs is implicated in the development and progression of various illnesses. Conversely, nanoparticle carriers offer unprecedented opportunities for cell-specific controlled delivery of miRNAs for therapeutic purposes. In this sense, we present in this graphical review critical evidence in the regulation of cell junction expression mediated by miRNAs induced by hypoxia and for the use of nanoparticles for the delivery of miRNA-based therapeutics in the treatment of BBB permeability.Elsevier B.V.2024202420222024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion5 p.application/pdfhttps://hdl.handle.net/2445/208726Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a:Current Research in Pharmacology and Drug Discovery ( CRPHAR, 2022, p. 1-5cc-by (c) Esteban G Figueroa et al., 2022http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2087262026-05-29T05:05:01Z
dc.title.none.fl_str_mv miRNA nanoencapsulation to regulate the programming of the blood-brain barrier permeability by hipoxia.
title miRNA nanoencapsulation to regulate the programming of the blood-brain barrier permeability by hipoxia.
spellingShingle miRNA nanoencapsulation to regulate the programming of the blood-brain barrier permeability by hipoxia.
Figueroa Becerra, Esteban
Micro RNAs
Anoxèmia
MicroRNAs
Anoxemia
title_short miRNA nanoencapsulation to regulate the programming of the blood-brain barrier permeability by hipoxia.
title_full miRNA nanoencapsulation to regulate the programming of the blood-brain barrier permeability by hipoxia.
title_fullStr miRNA nanoencapsulation to regulate the programming of the blood-brain barrier permeability by hipoxia.
title_full_unstemmed miRNA nanoencapsulation to regulate the programming of the blood-brain barrier permeability by hipoxia.
title_sort miRNA nanoencapsulation to regulate the programming of the blood-brain barrier permeability by hipoxia.
dc.creator.none.fl_str_mv Figueroa Becerra, Esteban
Caballero Roman, Aitor
Ticó Grau, Josep R.
Miñarro Carmona, Montserrat
Nardi Ricart, Anna
González Candia, Alejandro
author Figueroa Becerra, Esteban
author_facet Figueroa Becerra, Esteban
Caballero Roman, Aitor
Ticó Grau, Josep R.
Miñarro Carmona, Montserrat
Nardi Ricart, Anna
González Candia, Alejandro
author_role author
author2 Caballero Roman, Aitor
Ticó Grau, Josep R.
Miñarro Carmona, Montserrat
Nardi Ricart, Anna
González Candia, Alejandro
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Micro RNAs
Anoxèmia
MicroRNAs
Anoxemia
topic Micro RNAs
Anoxèmia
MicroRNAs
Anoxemia
description Central nervous system (CNS)-related diseases are difficult to treat as most therapeutic agents they cannot reach the brain tissue, mainly due to the blood-brain barrier (BBB), arguably the tightest barrier between the human body and cerebral parenchyma, which routinely excludes most xenobiotic therapeutics compounds. The BBB is a multicellular complex that structurally forms the neurovascular unit (NVU) and is organized by neuro-endothelial and glial cells. BBB breakdown and dysfunction from the cerebrovascular cells lead to leakages of systemic components from the blood into the CNS, contributing to neurological deficits. Understanding the molecular mechanisms that regulate BBB permeability and disruption is essential for establishing future therapeutic strategies to restore permeability and improve cerebrovascular health. MicroRNAs (miRNAs), a type of small noncoding RNAs, are emerging as an important regulator of BBB integrity by modulating gene expression by targeting mRNA transcripts. miRNAs is implicated in the development and progression of various illnesses. Conversely, nanoparticle carriers offer unprecedented opportunities for cell-specific controlled delivery of miRNAs for therapeutic purposes. In this sense, we present in this graphical review critical evidence in the regulation of cell junction expression mediated by miRNAs induced by hypoxia and for the use of nanoparticles for the delivery of miRNA-based therapeutics in the treatment of BBB permeability.
publishDate 2022
dc.date.none.fl_str_mv 2022
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/208726
url https://hdl.handle.net/2445/208726
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a:
Current Research in Pharmacology and Drug Discovery ( CRPHAR, 2022, p. 1-5
dc.rights.none.fl_str_mv cc-by (c) Esteban G Figueroa et al., 2022
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Esteban G Figueroa et al., 2022
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 5 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Farmàcia, Tecnologia Farmacèutica i Fisicoquímica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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