Expert consensus on the management of adverse events of Lorlatinib in the treatment of ALK+ advanced non-small cell lung cancer

The use of anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs), such as lorlatinib, for the treatment of patients with ALK gene rearrangement (or ALK-positive) non-small cell lung cancer (NSCLC) has been shown to improve the overall survival and quality of life of these patients. Howe...

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Detalles Bibliográficos
Autores: Arriola Aperribay, Edurne, Castro, Javier de, García Campelo, Rosario, Bernárdez, Beatriz, Bernabé, Reyes, Bruna, Jordi, Dómine, Manuel, Isla, Dolores, Juan Vidal, Óscar, López Fernández, Teresa, Nadal, Ernest, Rodríguez Abreu, Delvys, Vares, María, Asensio, Úrsula, García, Luis F., Felip, Enriqueta
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/222864
Acceso en línea:https://hdl.handle.net/2445/222864
Access Level:acceso abierto
Palabra clave:Medicaments antineoplàstics
Càncer de pulmó
Antineoplastic agents
Lung cancer
Descripción
Sumario:The use of anaplastic lymphoma kinase (ALK) tyrosine kinase inhibitors (TKIs), such as lorlatinib, for the treatment of patients with ALK gene rearrangement (or ALK-positive) non-small cell lung cancer (NSCLC) has been shown to improve the overall survival and quality of life of these patients. However, lorlatinib is not exempt from potential adverse events. Adequate monitoring and management of these adverse events are critical for increasing patient adherence to lorlatinib, thereby maximizing the benefits of treatment and minimizing the risks associated with treatment discontinuation. Considering that the adverse events of lorlatinib can affect different organs and systems, the participation of a multidisciplinary team, including cardiologists, neurologists, internal medicine specialists, and oncology pharmacists, is needed. This article presents specific and pragmatic strategies for identifying and treating the most relevant adverse events associated with lorlatinib in patients with advanced ALK-positive NSCLC based on the clinical experience of a multidisciplinary panel of experts.

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