Histological response to radiotherapy is an early event in myxoid liposarcoma

Myxoid liposarcoma; Personalized medicine; Radiotherapy

Detalles Bibliográficos
Autores: Lam, Suk Wai, Silva, Tulio M., Traast-Kooistra, Jolanda, Briaire de Bruijn, Inge H., van den Akker, Brendy, Bakker, Pauline A. C.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Departament de Salut de la Generalitat de Catalunya (DS)
Repositorio:Scientia. Dipòsit d'Informació Digital del Departament de Salut
OAI Identifier:oai:scientiasalut.gencat.cat:11351/10664
Acceso en línea:https://hdl.handle.net/11351/10664
Access Level:acceso abierto
Palabra clave:Teixit adipós - Càncer - Radioteràpia
Apoptosi
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Adipose Tissue::Liposarcoma::Liposarcoma, Myxoid
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Radiotherapy
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido adiposo::liposarcoma::liposarcoma mixoide
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::radioterapia
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis
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repository_id_str
spelling Histological response to radiotherapy is an early event in myxoid liposarcomaLam, Suk WaiSilva, Tulio M.Traast-Kooistra, JolandaBriaire de Bruijn, Inge H.van den Akker, BrendyBakker, Pauline A. C.Teixit adipós - Càncer - RadioteràpiaApoptosiDISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Adipose Tissue::Liposarcoma::Liposarcoma, MyxoidANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::RadiotherapyPHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::ApoptosisENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido adiposo::liposarcoma::liposarcoma mixoideTÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::radioterapiaFENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosisMyxoid liposarcoma; Personalized medicine; RadiotherapyLiposarcoma mixoide; Medicina personalizada; RadioterapiaLiposarcoma mixoide; Medicina personalitzada; RadioteràpiaCompared to other sarcomas, myxoid liposarcoma (MLS) is exceptionally sensitive to radiation therapy, but the underlying mechanism remains unknown. The objective was to assess the tissue-based changes in MLS during and after neoadjuvant radiotherapy in 26 patients of the DOREMY trial. Morphological assessment was performed on biopsies pre-treatment, after 8 fractions, 16 factions, and after surgical resection and included percentage of viable tumor cells, hyalinization, necrosis, and fatty maturation. Furthermore, immunohistochemistry was performed for apoptosis (cleaved caspase-3), anti-apoptosis (Bcl-2), activity of mTOR signaling (phospho-S6), hypoxia (CAIX), proliferation (Ki67), inflammation (CD45 and CD68), and microvessel density (CD34 Chalkley count). A pronounced reduction in vital tumor cells was observed early with a drop to 32.5% (median) tumor cells (IQR 10–93.8%) after 8 fractions. This decreased further to 10% (IQR 5–30%) after 16 fractions and 7.5% (IQR 5–15%) in the surgical specimen. All but one patient had an excellent response with < 50% remaining tumor cells. Inversely, treatment response was mainly observed as hyalinization and less often as fatty maturation. Additionally, a decrease of inflammatory cells was noticed especially during the first eight fractions. Microvessel density remained stable over time. Immunohistochemical markers for apoptosis, anti-apoptosis, activity of mTOR signaling, proliferation, and hypoxia did not show any marked changes within the remaining tumor cells during and after radiotherapy. As a modest dose of neoadjuvant radiotherapy induces profound tissue changes in MLS, mainly during the first 8 fractions, current findings might suggest that in a carefully selected patient population further deintensification of radiotherapy might be explored.SpringerInstitut Català de la Salut[Lam SW, Traast-Kooistra J, Bruijn IB, van den Akker B] Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. [Silva TM] Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. Servei d’Anatomia Patològica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Bakker PAC] Department of Radiotherapy, Leiden University Medical Center, Leiden, the NetherlandsVall d'Hebron Barcelona Hospital Campus202320232023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfapplication/pdfimage/tiffhttps://hdl.handle.net/11351/10664Scientiareponame:Scientia. Dipòsit d'Informació Digital del Departament de Salutinstname:Departament de Salut de la Generalitat de Catalunya (DS)InglésVirchows Archiv;483https://doi.org/10.1007/s00428-023-03615-5Attribution 4.0 Internationalhttp://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:scientiasalut.gencat.cat:11351/106642026-06-12T09:38:37Z
dc.title.none.fl_str_mv Histological response to radiotherapy is an early event in myxoid liposarcoma
title Histological response to radiotherapy is an early event in myxoid liposarcoma
spellingShingle Histological response to radiotherapy is an early event in myxoid liposarcoma
Lam, Suk Wai
Teixit adipós - Càncer - Radioteràpia
Apoptosi
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Adipose Tissue::Liposarcoma::Liposarcoma, Myxoid
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Radiotherapy
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido adiposo::liposarcoma::liposarcoma mixoide
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::radioterapia
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis
title_short Histological response to radiotherapy is an early event in myxoid liposarcoma
title_full Histological response to radiotherapy is an early event in myxoid liposarcoma
title_fullStr Histological response to radiotherapy is an early event in myxoid liposarcoma
title_full_unstemmed Histological response to radiotherapy is an early event in myxoid liposarcoma
title_sort Histological response to radiotherapy is an early event in myxoid liposarcoma
dc.creator.none.fl_str_mv Lam, Suk Wai
Silva, Tulio M.
Traast-Kooistra, Jolanda
Briaire de Bruijn, Inge H.
van den Akker, Brendy
Bakker, Pauline A. C.
author Lam, Suk Wai
author_facet Lam, Suk Wai
Silva, Tulio M.
Traast-Kooistra, Jolanda
Briaire de Bruijn, Inge H.
van den Akker, Brendy
Bakker, Pauline A. C.
author_role author
author2 Silva, Tulio M.
Traast-Kooistra, Jolanda
Briaire de Bruijn, Inge H.
van den Akker, Brendy
Bakker, Pauline A. C.
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Institut Català de la Salut
[Lam SW, Traast-Kooistra J, Bruijn IB, van den Akker B] Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. [Silva TM] Department of Pathology, Leiden University Medical Center, Leiden, the Netherlands. Servei d’Anatomia Patològica, Vall d’Hebron Hospital Universitari, Barcelona, Spain. [Bakker PAC] Department of Radiotherapy, Leiden University Medical Center, Leiden, the Netherlands
Vall d'Hebron Barcelona Hospital Campus
dc.subject.none.fl_str_mv Teixit adipós - Càncer - Radioteràpia
Apoptosi
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Adipose Tissue::Liposarcoma::Liposarcoma, Myxoid
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Radiotherapy
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido adiposo::liposarcoma::liposarcoma mixoide
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::radioterapia
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis
topic Teixit adipós - Càncer - Radioteràpia
Apoptosi
DISEASES::Neoplasms::Neoplasms by Histologic Type::Neoplasms, Connective and Soft Tissue::Neoplasms, Adipose Tissue::Liposarcoma::Liposarcoma, Myxoid
ANALYTICAL, DIAGNOSTIC AND THERAPEUTIC TECHNIQUES, AND EQUIPMENT::Therapeutics::Radiotherapy
PHENOMENA AND PROCESSES::Cell Physiological Phenomena::Cell Death::Apoptosis
ENFERMEDADES::neoplasias::neoplasias por tipo histológico::neoplasias de tejido conjuntivo y de tejidos blandos::neoplasias de tejido adiposo::liposarcoma::liposarcoma mixoide
TÉCNICAS Y EQUIPOS ANALÍTICOS, DIAGNÓSTICOS Y TERAPÉUTICOS::terapéutica::radioterapia
FENÓMENOS Y PROCESOS::fenómenos fisiológicos celulares::muerte celular::apoptosis
description Myxoid liposarcoma; Personalized medicine; Radiotherapy
publishDate 2023
dc.date.none.fl_str_mv 2023
2023
2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/11351/10664
url https://hdl.handle.net/11351/10664
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Virchows Archiv;483
https://doi.org/10.1007/s00428-023-03615-5
dc.rights.none.fl_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
application/pdf
image/tiff
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv Scientia
reponame:Scientia. Dipòsit d'Informació Digital del Departament de Salut
instname:Departament de Salut de la Generalitat de Catalunya (DS)
instname_str Departament de Salut de la Generalitat de Catalunya (DS)
reponame_str Scientia. Dipòsit d'Informació Digital del Departament de Salut
collection Scientia. Dipòsit d'Informació Digital del Departament de Salut
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,811543

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