Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Kanoni S.; Graham S.E.; Wang Y.; Surakka I.; Ramdas S.; Clarke S.L.; Bhatti K.F.; Vedantam S.; Winkler T.W.; Locke A.E.; Marouli E.; Zajac G.J.M.; Wu K.-H.H.; Ntalla I.; Hui Q.; Klarin D.; Hilliard A.T.; Xue C.; Thorleifsson G.; Helgadottir A.; Gudbjartsson D.F.; Holm H.; Olafsson I.; Hwang M.Y.; Han S.; Akiyama M.; Sakaue S.; Terao C.; Kanai M.; Zhou W.; Brumpton B.M.; Rasheed H.; Havulinna A.S.; Veturi Y.; Pacheco J.A.; Rosenthal E.A.; Lingren T.; Feng Q.P.; Kullo I.J.; Narita A.; Takayama J.; Martin H.C.; Hunt K.A.; Trivedi B.; Haessler J.; Giulianini F.; Bradford Y.; Miller J.E.; Campbell A.; Lin K.; Millwood I.Y.; Rasheed A.; Hindy G.; Faul J.D.; Zhao W.; Weir D.R.; Turman C.; Huang H.; Graff M.; Choudhury A.; Sengupta D.; Mahajan A.; Brown M.R.; Zhang W.; Yu K.; Schmidt E.M.; Pandit A.; Gustafsson S.; Yin X.; Luan J.; Zhao J.-H.; Matsuda F.; Jang H.-M.; Yoon K.; Medina-Gomez C.; Pitsillides A.; Hottenga J.J.; Wood A.R.; Ji Y.; Gao Z.; Haworth S.; Yousri N.A.; Mitchell R.E.; Chai J.F.; Aadahl M.; Bjerregaard A.A.; Yao J.; Manichaikul A.; Hwu C.-M.; Hung Y.-J.; Warren H.R.; Ramirez J.; Bork-Jensen J.; Kårhus L.L.; Goel A.; Sabater-Lleal M.; Noordam R.; Mauro P.; Matteo F.; McDaid A.F.; Marques-Vidal P.; Wielscher M.; Trompet S.; Sattar N.; Møllehave L.T.; Munz M.; Zeng L.; Huang J.; Yang B.; Poveda A.; Kurbasic A.; Lamina C.; Forer L.; Scholz M.; Galesloot T.E.; Bradfield J.P.; Ruotsalainen S.E.; Daw E.W.; Zmuda J.M.; Mitchell J.S.; Fuchsberger C.; Christensen H.; Brody J.A.; Vazquez-Moreno M.; Feitosa M.F.; Wojczynski M.K.; Wang Z.; Preuss M.H.; Mangino M.; Christofidou P.; Verweij N.; Benjamins J.W.; Engmann J.; Tsao N.L.; Verma A.; Slieker R.C.; Lo K.S.; Zilhao N.R.; Le P.; Kleber M.E.; Delgado G.E.; Huo S.; Ikeda D.D.; Iha H.; Demirkan A.; Leonard H.L.; Marten J.; Frank M.; Schmidt B.; Smyth L.J.; Cañadas-Garre M.; Wang C.; Nakatochi M.; Wong A.; Hutri-Kähönen N.; Sim X.; Xia R.; Huerta-Chagoya A.; Fernandez-Lopez J.C.; Lyssenko V.; Nongmaithem S.S.; Bayyana S.; Stringham H.M.; Irvin M.R.; Oldmeadow C.; Kim H.-N.; Ryu S.; Timmers P.R.H.J.; Arbeeva L.; Dorajoo R.; Lange L.A.; Prasad G.; Lorés-Motta L.; Pauper M.; Long J.; Theusch E.; Takeuchi F.; Spracklen C.N.; Loukola A.; Bollepalli S.; Warner S.C.; Wang Y.X.; Wei W.B.; Nutile T.; Ruggiero D.; Sung Y.J.; Chen S.; Liu F.; Yang J.; Kentistou K.A.; Banas B.; Nardone G.G.; Meidtner K.; Bielak L.F.; Smith J.A.; Hebbar P.; Farmaki A.-E.; Hofer E.; Lin M.; Concas M.P.; Vaccargiu S.; van der Most P.J.; Pitkänen N.; Cade B.E.; van der Laan S.W.; Chitrala K.N.; Weiss S.; Bentley A.R.; Doumatey A.P.; Adeyemo A.A.; Lee J.Y.; Petersen E.R.B.; Nielsen A.A.; Choi H.S.; Nethander M.; Freitag-Wolf S.; Southam L.; Rayner N.W.; Wang C.A.; Lin S.-Y.; Wang J.-S.; Couture C.; Lyytikäinen L.-P.; Nikus K.; Cuellar-Partida G.; Vestergaard H.; Hidalgo B.; Giannakopoulou O.; Cai Q.; Obura M.O.; van Setten J.; Li X.; Liang J.; Tang H.; Terzikhan N.; Shin J.H.; Jackson R.D.; Reiner A.P.; Martin L.W.; Chen Z.; Li L.; Kawaguchi T.; Thiery J.; Bis J.C.; Launer L.J.; Nalls M.A.; Raitakari O.T.; Ichihara S.; Wild S.H.; Nelson C.P.; Campbell H.; Jäger S.; Nabika T.; Al-Mulla F.; Niinikoski H.; Braund P.S.; Kolcic I.; Kovacs P.; Giardoglou T.; Katsuya T.; de Kleijn D.; de Borst G.J.; Kim E.K.; Adams H.H.H.; Ikram M.A.; Zhu X.; Asselbergs F.W.; Kraaijeveld A.O.; Beulens J.W.J.; Shu X.-O.; Rallidis L.S.; Pedersen O.; Hansen T.; Mitchell P.; Hewitt A.W.; Kähönen M.; Pérusse L.; Bouchard C.; Tönjes A.; Chen Y.-D.I.; Pennell C.E.; Mori T.A.; Lieb W.; Franke A.; Ohlsson C.; Mellström D.; Cho Y.S.; Lee H.; Yuan J.-M.; Koh W.-P.; Rhee S.Y.; Woo J.-T.; Heid I.M.; Stark K.J.; Zimmermann M.E.; Völzke H.; Homuth G.; Evans M.K.; Zonderman A.B.; Polasek O.; Pasterkamp G.; Hoefer I.E.; Redline S.; Pahkala K.; Oldehinkel A.J.; Snieder H.; Biino G.; Schmidt R.; Schmidt H.; Bandinelli S.; Dedoussis G.; Thanaraj T.A.; Kardia S.L.R.; Peyser P.A.; Kato N.; Schulze M.B.; Girotto G.; Böger C.A.; Jung B.; Joshi P.K.; Bennett D.A.; De Jager P.L.; Lu X.; Mamakou V.; Brown M.; Caulfield M.J.; Munroe P.B.; Guo X.; Ciullo M.; Jonas J.B.; Samani N.J.; Kaprio J.; Pajukanta P.; Tusié-Luna T.; Aguilar-Salinas C.A.; Adair L.S.; Bechayda S.A.; de Silva H.J.; Wickremasinghe A.R.; Krauss R.M.; Wu J.-Y.; Zheng W.; Hollander A.I.; Bharadwaj D.; Correa A.; Wilson J.G.; Lind L.; Heng C.-K.; Nelson A.E.; Golightly Y.M.; Wilson J.F.; Penninx B.; Kim H.-L.; Attia J.; Scott R.J.; Rao D.C.; Arnett D.K.; Hunt S.C.; Walker M.; Koistinen H.A.; Chandak G.R.; Mercader J.M.; Costanzo M.C.; Jang D.; Burtt N.P.; Villalpando C.G.; Orozco L.; Fornage M.; Tai E.S.; van Dam R.M.; Lehtimäki T.; Chaturvedi N.; Yokota M.; Liu J.; Reilly D.F.; McKnight A.J.; Kee F.; Jöckel K.-H.; McCarthy M.I.; Palmer C.N.A.; Vitart V.; Hayward C.; Simonsick E.; van Duijn C.M.; Jin Z.-B.; Qu J.; Hishigaki H.; Lin X.; März W.; Gudnason V.; Tardif J.-C.; Lettre G.; Hart L.M.; Elders P.J.M.; Damrauer S.M.; Kumari M.; Kivimaki M.; van der Harst P.; Spector T.D.; Loos R.J.F.; Province M.A.; Parra E.J.; Cruz M.; Psaty B.M.; Brandslund I.; Pramstaller P.P.; Rotimi C.N.; Christensen K.; Ripatti S.; Widén E.; Hakonarson H.; Grant S.F.A.; Kiemeney L.A.L.M.; de Graaf J.; Loeffler M.; Kronenberg F.; Gu D.; Erdmann J.; Schunkert H.; Franks P.W.; Linneberg A.; Jukema J.W.; Khera A.V.; Männikkö M.; Jarvelin M.-R.; Kutalik Z.; Francesco C.; Mook-Kanamori D.O.; van Dijk K.W.; Watkins H.; Strachan D.P.; Grarup N.; Sever P.; Poulter N.; Chuang L.-M.; Rotter J.I.; Dantoft T.M.; Karpe F.; Neville M.J.; Timpson N.J.; Cheng C.-Y.; Wong T.-Y.; Khor C.C.; Li H.; Sabanayagam C.; Peters A.; Gieger C.; Hattersley A.T.; Pedersen N.L.; Magnusson P.K.E.; Boomsma D.I.; Willemsen A.H.M.; Cupples L.A.; van Meurs J.B.J.; Ghanbari M.; Gordon-Larsen P.; Huang W.; Kim Y.J.; Tabara Y.; Wareham N.J.; Langenberg C.; Zeggini E.; Kuusisto J.; Laakso M.; Ingelsson E.; Abecasis G.; Chambers J.C.; Kooner J.S.; de Vries P.S.; Morrison A.C.; Hazelhurst S.; Ramsay M.; North K.E.; Daviglus M.; Kraft P.; Martin N.G.; Whitfield J.B.; Abbas S.; Saleheen D.; Walters R.G.; Holmes M.V.; Black C.; Smith B.H.; Baras A.; Justice A.E.; Buring J.E.; Ridker P.M.; Chasman D.I.; Kooperberg C.; Tamiya G.; Yamamoto M.; van Heel D.A.; Trembath R.C.; Wei W.-Q.; Jarvik G.P.; Namjou B.; Hayes M.G.; Ritchie M.D.; Jousilahti P.; Salomaa V.; Hveem K.; Åsvold B.O.; Kubo M.; Kamatani Y.; Okada Y.; Murakami Y.; Kim B.-J.; Thorsteinsdottir U.; Stefansson K.; Zhang J.; Chen Y.E.; Ho Y.-L.; Lynch J.A.; Rader D.J.; Tsao P.S.; Chang K.-M.; Cho K.; O’Donnell C.J.; Gaziano J.M.; Wilson P.W.F.; Frayling T.M.; Hirschhorn J.N.; Kathiresan S.; Mohlke K.L.; Sun Y.V.; Morris A.P.; Boehnke M.; Brown C.D.; Natarajan P.; Deloukas P.; Willer C.J.; Assimes T.L.; Peloso G.M.

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as dru...

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Detalhes bibliográficos
Autores:	Kanoni S., Graham S.E., Wang Y., Surakka I., Ramdas S., Clarke S.L., Bhatti K.F., Vedantam S., Winkler T.W., Locke A.E., Marouli E., Zajac G.J.M., Wu K.-H.H., Ntalla I., Hui Q., Klarin D., Hilliard A.T., Xue C., Thorleifsson G., Helgadottir A., Gudbjartsson D.F., Holm H., Olafsson I., Hwang M.Y., Han S., Akiyama M., Sakaue S., Terao C., Kanai M., Zhou W., Brumpton B.M., Rasheed H., Havulinna A.S., Veturi Y., Pacheco J.A., Rosenthal E.A., Lingren T., Feng Q.P., Kullo I.J., Narita A., Takayama J., Martin H.C., Hunt K.A., Trivedi B., Haessler J., Giulianini F., Bradford Y., Miller J.E., Campbell A., Lin K., Millwood I.Y., Rasheed A., Hindy G., Faul J.D., Zhao W., Weir D.R., Turman C., Huang H., Graff M., Choudhury A., Sengupta D., Mahajan A., Brown M.R., Zhang W., Yu K., Schmidt E.M., Pandit A., Gustafsson S., Yin X., Luan J., Zhao J.-H., Matsuda F., Jang H.-M., Yoon K., Medina-Gomez C., Pitsillides A., Hottenga J.J., Wood A.R., Ji Y., Gao Z., Haworth S., Yousri N.A., Mitchell R.E., Chai J.F., Aadahl M., Bjerregaard A.A., Yao J., Manichaikul A., Hwu C.-M., Hung Y.-J., Warren H.R., Ramirez J., Bork-Jensen J., Kårhus L.L., Goel A., Sabater-Lleal M., Noordam R., Mauro P., Matteo F., McDaid A.F., Marques-Vidal P., Wielscher M., Trompet S., Sattar N., Møllehave L.T., Munz M., Zeng L., Huang J., Yang B., Poveda A., Kurbasic A., Lamina C., Forer L., Scholz M., Galesloot T.E., Bradfield J.P., Ruotsalainen S.E., Daw E.W., Zmuda J.M., Mitchell J.S., Fuchsberger C., Christensen H., Brody J.A., Vazquez-Moreno M., Feitosa M.F., Wojczynski M.K., Wang Z., Preuss M.H., Mangino M., Christofidou P., Verweij N., Benjamins J.W., Engmann J., Tsao N.L., Verma A., Slieker R.C., Lo K.S., Zilhao N.R., Le P., Kleber M.E., Delgado G.E., Huo S., Ikeda D.D., Iha H., Demirkan A., Leonard H.L., Marten J., Frank M., Schmidt B., Smyth L.J., Cañadas-Garre M., Wang C., Nakatochi M., Wong A., Hutri-Kähönen N., Sim X., Xia R., Huerta-Chagoya A., Fernandez-Lopez J.C., Lyssenko V., Nongmaithem S.S., Bayyana S., Stringham H.M., Irvin M.R., Oldmeadow C., Kim H.-N., Ryu S., Timmers P.R.H.J., Arbeeva L., Dorajoo R., Lange L.A., Prasad G., Lorés-Motta L., Pauper M., Long J., Theusch E., Takeuchi F., Spracklen C.N., Loukola A., Bollepalli S., Warner S.C., Wang Y.X., Wei W.B., Nutile T., Ruggiero D., Sung Y.J., Chen S., Liu F., Yang J., Kentistou K.A., Banas B., Nardone G.G., Meidtner K., Bielak L.F., Smith J.A., Hebbar P., Farmaki A.-E., Hofer E., Lin M., Concas M.P., Vaccargiu S., van der Most P.J., Pitkänen N., Cade B.E., van der Laan S.W., Chitrala K.N., Weiss S., Bentley A.R., Doumatey A.P., Adeyemo A.A., Lee J.Y., Petersen E.R.B., Nielsen A.A., Choi H.S., Nethander M., Freitag-Wolf S., Southam L., Rayner N.W., Wang C.A., Lin S.-Y., Wang J.-S., Couture C., Lyytikäinen L.-P., Nikus K., Cuellar-Partida G., Vestergaard H., Hidalgo B., Giannakopoulou O., Cai Q., Obura M.O., van Setten J., Li X., Liang J., Tang H., Terzikhan N., Shin J.H., Jackson R.D., Reiner A.P., Martin L.W., Chen Z., Li L., Kawaguchi T., Thiery J., Bis J.C., Launer L.J., Nalls M.A., Raitakari O.T., Ichihara S., Wild S.H., Nelson C.P., Campbell H., Jäger S., Nabika T., Al-Mulla F., Niinikoski H., Braund P.S., Kolcic I., Kovacs P., Giardoglou T., Katsuya T., de Kleijn D., de Borst G.J., Kim E.K., Adams H.H.H., Ikram M.A., Zhu X., Asselbergs F.W., Kraaijeveld A.O., Beulens J.W.J., Shu X.-O., Rallidis L.S., Pedersen O., Hansen T., Mitchell P., Hewitt A.W., Kähönen M., Pérusse L., Bouchard C., Tönjes A., Chen Y.-D.I., Pennell C.E., Mori T.A., Lieb W., Franke A., Ohlsson C., Mellström D., Cho Y.S., Lee H., Yuan J.-M., Koh W.-P., Rhee S.Y., Woo J.-T., Heid I.M., Stark K.J., Zimmermann M.E., Völzke H., Homuth G., Evans M.K., Zonderman A.B., Polasek O., Pasterkamp G., Hoefer I.E., Redline S., Pahkala K., Oldehinkel A.J., Snieder H., Biino G., Schmidt R., Schmidt H., Bandinelli S., Dedoussis G., Thanaraj T.A., Kardia S.L.R., Peyser P.A., Kato N., Schulze M.B., Girotto G., Böger C.A., Jung B., Joshi P.K., Bennett D.A., De Jager P.L., Lu X., Mamakou V., Brown M., Caulfield M.J., Munroe P.B., Guo X., Ciullo M., Jonas J.B., Samani N.J., Kaprio J., Pajukanta P., Tusié-Luna T., Aguilar-Salinas C.A., Adair L.S., Bechayda S.A., de Silva H.J., Wickremasinghe A.R., Krauss R.M., Wu J.-Y., Zheng W., Hollander A.I., Bharadwaj D., Correa A., Wilson J.G., Lind L., Heng C.-K., Nelson A.E., Golightly Y.M., Wilson J.F., Penninx B., Kim H.-L., Attia J., Scott R.J., Rao D.C., Arnett D.K., Hunt S.C., Walker M., Koistinen H.A., Chandak G.R., Mercader J.M., Costanzo M.C., Jang D., Burtt N.P., Villalpando C.G., Orozco L., Fornage M., Tai E.S., van Dam R.M., Lehtimäki T., Chaturvedi N., Yokota M., Liu J., Reilly D.F., McKnight A.J., Kee F., Jöckel K.-H., McCarthy M.I., Palmer C.N.A., Vitart V., Hayward C., Simonsick E., van Duijn C.M., Jin Z.-B., Qu J., Hishigaki H., Lin X., März W., Gudnason V., Tardif J.-C., Lettre G., Hart L.M., Elders P.J.M., Damrauer S.M., Kumari M., Kivimaki M., van der Harst P., Spector T.D., Loos R.J.F., Province M.A., Parra E.J., Cruz M., Psaty B.M., Brandslund I., Pramstaller P.P., Rotimi C.N., Christensen K., Ripatti S., Widén E., Hakonarson H., Grant S.F.A., Kiemeney L.A.L.M., de Graaf J., Loeffler M., Kronenberg F., Gu D., Erdmann J., Schunkert H., Franks P.W., Linneberg A., Jukema J.W., Khera A.V., Männikkö M., Jarvelin M.-R., Kutalik Z., Francesco C., Mook-Kanamori D.O., van Dijk K.W., Watkins H., Strachan D.P., Grarup N., Sever P., Poulter N., Chuang L.-M., Rotter J.I., Dantoft T.M., Karpe F., Neville M.J., Timpson N.J., Cheng C.-Y., Wong T.-Y., Khor C.C., Li H., Sabanayagam C., Peters A., Gieger C., Hattersley A.T., Pedersen N.L., Magnusson P.K.E., Boomsma D.I., Willemsen A.H.M., Cupples L.A., van Meurs J.B.J., Ghanbari M., Gordon-Larsen P., Huang W., Kim Y.J., Tabara Y., Wareham N.J., Langenberg C., Zeggini E., Kuusisto J., Laakso M., Ingelsson E., Abecasis G., Chambers J.C., Kooner J.S., de Vries P.S., Morrison A.C., Hazelhurst S., Ramsay M., North K.E., Daviglus M., Kraft P., Martin N.G., Whitfield J.B., Abbas S., Saleheen D., Walters R.G., Holmes M.V., Black C., Smith B.H., Baras A., Justice A.E., Buring J.E., Ridker P.M., Chasman D.I., Kooperberg C., Tamiya G., Yamamoto M., van Heel D.A., Trembath R.C., Wei W.-Q., Jarvik G.P., Namjou B., Hayes M.G., Ritchie M.D., Jousilahti P., Salomaa V., Hveem K., Åsvold B.O., Kubo M., Kamatani Y., Okada Y., Murakami Y., Kim B.-J., Thorsteinsdottir U., Stefansson K., Zhang J., Chen Y.E., Ho Y.-L., Lynch J.A., Rader D.J., Tsao P.S., Chang K.-M., Cho K., O’Donnell C.J., Gaziano J.M., Wilson P.W.F., Frayling T.M., Hirschhorn J.N., Kathiresan S., Mohlke K.L., Sun Y.V., Morris A.P., Boehnke M., Brown C.D., Natarajan P., Deloukas P., Willer C.J., Assimes T.L., Peloso G.M.
Formato:	artículo
Estado:	Versión publicada
Fecha de publicación:	2022
País:	España
Recursos:	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
Repositorio:	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
OAI Identifier:	oai:iibsantpau.fundanetsuite.com:p15957
Acesso em linha:	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15957
Access Level:	acceso abierto
Palavra-chave:	lipid genetic predisposition genetics genome-wide association study human meta analysis phenotype pleiotropy sexual characteristics single nucleotide polymorphism Genetic Pleiotropy Genetic Predisposition to Disease Genome-Wide Association Study Humans Lipids Phenotype Polymorphism, Single Nucleotide Sex Characteristics

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oai_identifier_str	oai:iibsantpau.fundanetsuite.com:p15957
network_acronym_str	ES
network_name_str	España
repository_id_str
dc.title.none.fl_str_mv	Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
title	Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
spellingShingle	Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis Kanoni S. lipid genetic predisposition genetics genome-wide association study human meta analysis phenotype pleiotropy sexual characteristics single nucleotide polymorphism Genetic Pleiotropy Genetic Predisposition to Disease Genome-Wide Association Study Humans Lipids Phenotype Polymorphism, Single Nucleotide Sex Characteristics
title_short	Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
title_full	Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
title_fullStr	Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
title_full_unstemmed	Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
title_sort	Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
dc.creator.none.fl_str_mv	Kanoni S. Graham S.E. Wang Y. Surakka I. Ramdas S. Clarke S.L. Bhatti K.F. Vedantam S. Winkler T.W. Locke A.E. Marouli E. Zajac G.J.M. Wu K.-H.H. Ntalla I. Hui Q. Klarin D. Hilliard A.T. Xue C. Thorleifsson G. Helgadottir A. Gudbjartsson D.F. Holm H. Olafsson I. Hwang M.Y. Han S. Akiyama M. Sakaue S. Terao C. Kanai M. Zhou W. Brumpton B.M. Rasheed H. Havulinna A.S. Veturi Y. Pacheco J.A. Rosenthal E.A. Lingren T. Feng Q.P. Kullo I.J. Narita A. Takayama J. Martin H.C. Hunt K.A. Trivedi B. Haessler J. Giulianini F. Bradford Y. Miller J.E. Campbell A. Lin K. Millwood I.Y. Rasheed A. Hindy G. Faul J.D. Zhao W. Weir D.R. Turman C. Huang H. Graff M. Choudhury A. Sengupta D. Mahajan A. Brown M.R. Zhang W. Yu K. Schmidt E.M. Pandit A. Gustafsson S. Yin X. Luan J. Zhao J.-H. Matsuda F. Jang H.-M. Yoon K. Medina-Gomez C. Pitsillides A. Hottenga J.J. Wood A.R. Ji Y. Gao Z. Haworth S. Yousri N.A. Mitchell R.E. Chai J.F. Aadahl M. Bjerregaard A.A. Yao J. Manichaikul A. Hwu C.-M. Hung Y.-J. Warren H.R. Ramirez J. Bork-Jensen J. Kårhus L.L. Goel A. Sabater-Lleal M. Noordam R. Mauro P. Matteo F. McDaid A.F. Marques-Vidal P. Wielscher M. Trompet S. Sattar N. Møllehave L.T. Munz M. Zeng L. Huang J. Yang B. Poveda A. Kurbasic A. Lamina C. Forer L. Scholz M. Galesloot T.E. Bradfield J.P. Ruotsalainen S.E. Daw E.W. Zmuda J.M. Mitchell J.S. Fuchsberger C. Christensen H. Brody J.A. Vazquez-Moreno M. Feitosa M.F. Wojczynski M.K. Wang Z. Preuss M.H. Mangino M. Christofidou P. Verweij N. Benjamins J.W. Engmann J. Tsao N.L. Verma A. Slieker R.C. Lo K.S. Zilhao N.R. Le P. Kleber M.E. Delgado G.E. Huo S. Ikeda D.D. Iha H. Demirkan A. Leonard H.L. Marten J. Frank M. Schmidt B. Smyth L.J. Cañadas-Garre M. Wang C. Nakatochi M. Wong A. Hutri-Kähönen N. Sim X. Xia R. Huerta-Chagoya A. Fernandez-Lopez J.C. Lyssenko V. Nongmaithem S.S. Bayyana S. Stringham H.M. Irvin M.R. Oldmeadow C. Kim H.-N. Ryu S. Timmers P.R.H.J. Arbeeva L. Dorajoo R. Lange L.A. Prasad G. Lorés-Motta L. Pauper M. Long J. Theusch E. Takeuchi F. Spracklen C.N. Loukola A. Bollepalli S. Warner S.C. Wang Y.X. Wei W.B. Nutile T. Ruggiero D. Sung Y.J. Chen S. Liu F. Yang J. Kentistou K.A. Banas B. Nardone G.G. Meidtner K. Bielak L.F. Smith J.A. Hebbar P. Farmaki A.-E. Hofer E. Lin M. Concas M.P. Vaccargiu S. van der Most P.J. Pitkänen N. Cade B.E. van der Laan S.W. Chitrala K.N. Weiss S. Bentley A.R. Doumatey A.P. Adeyemo A.A. Lee J.Y. Petersen E.R.B. Nielsen A.A. Choi H.S. Nethander M. Freitag-Wolf S. Southam L. Rayner N.W. Wang C.A. Lin S.-Y. Wang J.-S. Couture C. Lyytikäinen L.-P. Nikus K. Cuellar-Partida G. Vestergaard H. Hidalgo B. Giannakopoulou O. Cai Q. Obura M.O. van Setten J. Li X. Liang J. Tang H. Terzikhan N. Shin J.H. Jackson R.D. Reiner A.P. Martin L.W. Chen Z. Li L. Kawaguchi T. Thiery J. Bis J.C. Launer L.J. Nalls M.A. Raitakari O.T. Ichihara S. Wild S.H. Nelson C.P. Campbell H. Jäger S. Nabika T. Al-Mulla F. Niinikoski H. Braund P.S. Kolcic I. Kovacs P. Giardoglou T. Katsuya T. de Kleijn D. de Borst G.J. Kim E.K. Adams H.H.H. Ikram M.A. Zhu X. Asselbergs F.W. Kraaijeveld A.O. Beulens J.W.J. Shu X.-O. Rallidis L.S. Pedersen O. Hansen T. Mitchell P. Hewitt A.W. Kähönen M. Pérusse L. Bouchard C. Tönjes A. Chen Y.-D.I. Pennell C.E. Mori T.A. Lieb W. Franke A. Ohlsson C. Mellström D. Cho Y.S. Lee H. Yuan J.-M. Koh W.-P. Rhee S.Y. Woo J.-T. Heid I.M. Stark K.J. Zimmermann M.E. Völzke H. Homuth G. Evans M.K. Zonderman A.B. Polasek O. Pasterkamp G. Hoefer I.E. Redline S. Pahkala K. Oldehinkel A.J. Snieder H. Biino G. Schmidt R. Schmidt H. Bandinelli S. Dedoussis G. Thanaraj T.A. Kardia S.L.R. Peyser P.A. Kato N. Schulze M.B. Girotto G. Böger C.A. Jung B. Joshi P.K. Bennett D.A. De Jager P.L. Lu X. Mamakou V. Brown M. Caulfield M.J. Munroe P.B. Guo X. Ciullo M. Jonas J.B. Samani N.J. Kaprio J. Pajukanta P. Tusié-Luna T. Aguilar-Salinas C.A. Adair L.S. Bechayda S.A. de Silva H.J. Wickremasinghe A.R. Krauss R.M. Wu J.-Y. Zheng W. Hollander A.I. Bharadwaj D. Correa A. Wilson J.G. Lind L. Heng C.-K. Nelson A.E. Golightly Y.M. Wilson J.F. Penninx B. Kim H.-L. Attia J. Scott R.J. Rao D.C. Arnett D.K. Hunt S.C. Walker M. Koistinen H.A. Chandak G.R. Mercader J.M. Costanzo M.C. Jang D. Burtt N.P. Villalpando C.G. Orozco L. Fornage M. Tai E.S. van Dam R.M. Lehtimäki T. Chaturvedi N. Yokota M. Liu J. Reilly D.F. McKnight A.J. Kee F. Jöckel K.-H. McCarthy M.I. Palmer C.N.A. Vitart V. Hayward C. Simonsick E. van Duijn C.M. Jin Z.-B. Qu J. Hishigaki H. Lin X. März W. Gudnason V. Tardif J.-C. Lettre G. Hart L.M. Elders P.J.M. Damrauer S.M. Kumari M. Kivimaki M. van der Harst P. Spector T.D. Loos R.J.F. Province M.A. Parra E.J. Cruz M. Psaty B.M. Brandslund I. Pramstaller P.P. Rotimi C.N. Christensen K. Ripatti S. Widén E. Hakonarson H. Grant S.F.A. Kiemeney L.A.L.M. de Graaf J. Loeffler M. Kronenberg F. Gu D. Erdmann J. Schunkert H. Franks P.W. Linneberg A. Jukema J.W. Khera A.V. Männikkö M. Jarvelin M.-R. Kutalik Z. Francesco C. Mook-Kanamori D.O. van Dijk K.W. Watkins H. Strachan D.P. Grarup N. Sever P. Poulter N. Chuang L.-M. Rotter J.I. Dantoft T.M. Karpe F. Neville M.J. Timpson N.J. Cheng C.-Y. Wong T.-Y. Khor C.C. Li H. Sabanayagam C. Peters A. Gieger C. Hattersley A.T. Pedersen N.L. Magnusson P.K.E. Boomsma D.I. Willemsen A.H.M. Cupples L.A. van Meurs J.B.J. Ghanbari M. Gordon-Larsen P. Huang W. Kim Y.J. Tabara Y. Wareham N.J. Langenberg C. Zeggini E. Kuusisto J. Laakso M. Ingelsson E. Abecasis G. Chambers J.C. Kooner J.S. de Vries P.S. Morrison A.C. Hazelhurst S. Ramsay M. North K.E. Daviglus M. Kraft P. Martin N.G. Whitfield J.B. Abbas S. Saleheen D. Walters R.G. Holmes M.V. Black C. Smith B.H. Baras A. Justice A.E. Buring J.E. Ridker P.M. Chasman D.I. Kooperberg C. Tamiya G. Yamamoto M. van Heel D.A. Trembath R.C. Wei W.-Q. Jarvik G.P. Namjou B. Hayes M.G. Ritchie M.D. Jousilahti P. Salomaa V. Hveem K. Åsvold B.O. Kubo M. Kamatani Y. Okada Y. Murakami Y. Kim B.-J. Thorsteinsdottir U. Stefansson K. Zhang J. Chen Y.E. Ho Y.-L. Lynch J.A. Rader D.J. Tsao P.S. Chang K.-M. Cho K. O’Donnell C.J. Gaziano J.M. Wilson P.W.F. Frayling T.M. Hirschhorn J.N. Kathiresan S. Mohlke K.L. Sun Y.V. Morris A.P. Boehnke M. Brown C.D. Natarajan P. Deloukas P. Willer C.J. Assimes T.L. Peloso G.M.
author	Kanoni S.
author_facet	Kanoni S. Graham S.E. Wang Y. Surakka I. Ramdas S. Clarke S.L. Bhatti K.F. Vedantam S. Winkler T.W. Locke A.E. Marouli E. Zajac G.J.M. Wu K.-H.H. Ntalla I. Hui Q. Klarin D. Hilliard A.T. Xue C. Thorleifsson G. Helgadottir A. Gudbjartsson D.F. Holm H. Olafsson I. Hwang M.Y. Han S. Akiyama M. Sakaue S. Terao C. Kanai M. Zhou W. Brumpton B.M. Rasheed H. Havulinna A.S. Veturi Y. Pacheco J.A. Rosenthal E.A. Lingren T. Feng Q.P. Kullo I.J. Narita A. Takayama J. Martin H.C. Hunt K.A. Trivedi B. Haessler J. Giulianini F. Bradford Y. Miller J.E. Campbell A. Lin K. Millwood I.Y. Rasheed A. Hindy G. Faul J.D. Zhao W. Weir D.R. Turman C. Huang H. Graff M. Choudhury A. Sengupta D. Mahajan A. Brown M.R. Zhang W. Yu K. Schmidt E.M. Pandit A. Gustafsson S. Yin X. Luan J. Zhao J.-H. Matsuda F. Jang H.-M. Yoon K. Medina-Gomez C. Pitsillides A. Hottenga J.J. Wood A.R. Ji Y. Gao Z. Haworth S. Yousri N.A. Mitchell R.E. Chai J.F. Aadahl M. Bjerregaard A.A. Yao J. Manichaikul A. Hwu C.-M. Hung Y.-J. Warren H.R. Ramirez J. Bork-Jensen J. Kårhus L.L. Goel A. Sabater-Lleal M. Noordam R. Mauro P. Matteo F. McDaid A.F. Marques-Vidal P. Wielscher M. Trompet S. Sattar N. Møllehave L.T. Munz M. Zeng L. Huang J. Yang B. Poveda A. Kurbasic A. Lamina C. Forer L. Scholz M. Galesloot T.E. Bradfield J.P. Ruotsalainen S.E. Daw E.W. Zmuda J.M. Mitchell J.S. Fuchsberger C. Christensen H. Brody J.A. Vazquez-Moreno M. Feitosa M.F. Wojczynski M.K. Wang Z. Preuss M.H. Mangino M. Christofidou P. Verweij N. Benjamins J.W. Engmann J. Tsao N.L. Verma A. Slieker R.C. Lo K.S. Zilhao N.R. Le P. Kleber M.E. Delgado G.E. Huo S. Ikeda D.D. Iha H. Demirkan A. Leonard H.L. Marten J. Frank M. Schmidt B. Smyth L.J. Cañadas-Garre M. Wang C. Nakatochi M. Wong A. Hutri-Kähönen N. Sim X. Xia R. Huerta-Chagoya A. Fernandez-Lopez J.C. Lyssenko V. Nongmaithem S.S. Bayyana S. Stringham H.M. Irvin M.R. Oldmeadow C. Kim H.-N. Ryu S. Timmers P.R.H.J. Arbeeva L. Dorajoo R. Lange L.A. Prasad G. Lorés-Motta L. Pauper M. Long J. Theusch E. Takeuchi F. Spracklen C.N. Loukola A. Bollepalli S. Warner S.C. Wang Y.X. Wei W.B. Nutile T. Ruggiero D. Sung Y.J. Chen S. Liu F. Yang J. Kentistou K.A. Banas B. Nardone G.G. Meidtner K. Bielak L.F. Smith J.A. Hebbar P. Farmaki A.-E. Hofer E. Lin M. Concas M.P. Vaccargiu S. van der Most P.J. Pitkänen N. Cade B.E. van der Laan S.W. Chitrala K.N. Weiss S. Bentley A.R. Doumatey A.P. Adeyemo A.A. Lee J.Y. Petersen E.R.B. Nielsen A.A. Choi H.S. Nethander M. Freitag-Wolf S. Southam L. Rayner N.W. Wang C.A. Lin S.-Y. Wang J.-S. Couture C. Lyytikäinen L.-P. Nikus K. Cuellar-Partida G. Vestergaard H. Hidalgo B. Giannakopoulou O. Cai Q. Obura M.O. van Setten J. Li X. Liang J. Tang H. Terzikhan N. Shin J.H. Jackson R.D. Reiner A.P. Martin L.W. Chen Z. Li L. Kawaguchi T. Thiery J. Bis J.C. Launer L.J. Nalls M.A. Raitakari O.T. Ichihara S. Wild S.H. Nelson C.P. Campbell H. Jäger S. Nabika T. Al-Mulla F. Niinikoski H. Braund P.S. Kolcic I. Kovacs P. Giardoglou T. Katsuya T. de Kleijn D. de Borst G.J. Kim E.K. Adams H.H.H. Ikram M.A. Zhu X. Asselbergs F.W. Kraaijeveld A.O. Beulens J.W.J. Shu X.-O. Rallidis L.S. Pedersen O. Hansen T. Mitchell P. Hewitt A.W. Kähönen M. Pérusse L. Bouchard C. Tönjes A. Chen Y.-D.I. Pennell C.E. Mori T.A. Lieb W. Franke A. Ohlsson C. Mellström D. Cho Y.S. Lee H. Yuan J.-M. Koh W.-P. Rhee S.Y. Woo J.-T. Heid I.M. Stark K.J. Zimmermann M.E. Völzke H. Homuth G. Evans M.K. Zonderman A.B. Polasek O. Pasterkamp G. Hoefer I.E. Redline S. Pahkala K. Oldehinkel A.J. Snieder H. Biino G. Schmidt R. Schmidt H. Bandinelli S. Dedoussis G. Thanaraj T.A. Kardia S.L.R. Peyser P.A. Kato N. Schulze M.B. Girotto G. Böger C.A. Jung B. Joshi P.K. Bennett D.A. De Jager P.L. Lu X. Mamakou V. Brown M. Caulfield M.J. Munroe P.B. Guo X. Ciullo M. Jonas J.B. Samani N.J. Kaprio J. Pajukanta P. Tusié-Luna T. Aguilar-Salinas C.A. Adair L.S. Bechayda S.A. de Silva H.J. Wickremasinghe A.R. Krauss R.M. Wu J.-Y. Zheng W. Hollander A.I. Bharadwaj D. Correa A. Wilson J.G. Lind L. Heng C.-K. Nelson A.E. Golightly Y.M. Wilson J.F. Penninx B. Kim H.-L. Attia J. Scott R.J. Rao D.C. Arnett D.K. Hunt S.C. Walker M. Koistinen H.A. Chandak G.R. Mercader J.M. Costanzo M.C. Jang D. Burtt N.P. Villalpando C.G. Orozco L. Fornage M. Tai E.S. van Dam R.M. Lehtimäki T. Chaturvedi N. Yokota M. Liu J. Reilly D.F. McKnight A.J. Kee F. Jöckel K.-H. McCarthy M.I. Palmer C.N.A. Vitart V. Hayward C. Simonsick E. van Duijn C.M. Jin Z.-B. Qu J. Hishigaki H. Lin X. März W. Gudnason V. Tardif J.-C. Lettre G. Hart L.M. Elders P.J.M. Damrauer S.M. Kumari M. Kivimaki M. van der Harst P. Spector T.D. Loos R.J.F. Province M.A. Parra E.J. Cruz M. Psaty B.M. Brandslund I. Pramstaller P.P. Rotimi C.N. Christensen K. Ripatti S. Widén E. Hakonarson H. Grant S.F.A. Kiemeney L.A.L.M. de Graaf J. Loeffler M. Kronenberg F. Gu D. Erdmann J. Schunkert H. Franks P.W. Linneberg A. Jukema J.W. Khera A.V. Männikkö M. Jarvelin M.-R. Kutalik Z. Francesco C. Mook-Kanamori D.O. van Dijk K.W. Watkins H. Strachan D.P. Grarup N. Sever P. Poulter N. Chuang L.-M. Rotter J.I. Dantoft T.M. Karpe F. Neville M.J. Timpson N.J. Cheng C.-Y. Wong T.-Y. Khor C.C. Li H. Sabanayagam C. Peters A. Gieger C. Hattersley A.T. Pedersen N.L. Magnusson P.K.E. Boomsma D.I. Willemsen A.H.M. Cupples L.A. van Meurs J.B.J. Ghanbari M. Gordon-Larsen P. Huang W. Kim Y.J. Tabara Y. Wareham N.J. Langenberg C. Zeggini E. Kuusisto J. Laakso M. Ingelsson E. Abecasis G. Chambers J.C. Kooner J.S. de Vries P.S. Morrison A.C. Hazelhurst S. Ramsay M. North K.E. Daviglus M. Kraft P. Martin N.G. Whitfield J.B. Abbas S. Saleheen D. Walters R.G. Holmes M.V. Black C. Smith B.H. Baras A. Justice A.E. Buring J.E. Ridker P.M. Chasman D.I. Kooperberg C. Tamiya G. Yamamoto M. van Heel D.A. Trembath R.C. Wei W.-Q. Jarvik G.P. Namjou B. Hayes M.G. Ritchie M.D. Jousilahti P. Salomaa V. Hveem K. Åsvold B.O. Kubo M. Kamatani Y. Okada Y. Murakami Y. Kim B.-J. Thorsteinsdottir U. Stefansson K. Zhang J. Chen Y.E. Ho Y.-L. Lynch J.A. Rader D.J. Tsao P.S. Chang K.-M. Cho K. O’Donnell C.J. Gaziano J.M. Wilson P.W.F. Frayling T.M. Hirschhorn J.N. Kathiresan S. Mohlke K.L. Sun Y.V. Morris A.P. Boehnke M. Brown C.D. Natarajan P. Deloukas P. Willer C.J. Assimes T.L. Peloso G.M.
author_role	author
author2	Graham S.E. Wang Y. Surakka I. Ramdas S. Clarke S.L. Bhatti K.F. Vedantam S. Winkler T.W. Locke A.E. Marouli E. Zajac G.J.M. Wu K.-H.H. Ntalla I. Hui Q. Klarin D. Hilliard A.T. Xue C. Thorleifsson G. Helgadottir A. Gudbjartsson D.F. Holm H. Olafsson I. Hwang M.Y. Han S. Akiyama M. Sakaue S. Terao C. Kanai M. Zhou W. Brumpton B.M. Rasheed H. Havulinna A.S. Veturi Y. Pacheco J.A. Rosenthal E.A. Lingren T. Feng Q.P. Kullo I.J. Narita A. Takayama J. Martin H.C. Hunt K.A. Trivedi B. Haessler J. Giulianini F. Bradford Y. Miller J.E. Campbell A. Lin K. Millwood I.Y. Rasheed A. Hindy G. Faul J.D. Zhao W. Weir D.R. Turman C. Huang H. Graff M. Choudhury A. Sengupta D. Mahajan A. Brown M.R. Zhang W. Yu K. Schmidt E.M. Pandit A. Gustafsson S. Yin X. Luan J. Zhao J.-H. Matsuda F. Jang H.-M. Yoon K. Medina-Gomez C. Pitsillides A. Hottenga J.J. Wood A.R. Ji Y. Gao Z. Haworth S. Yousri N.A. Mitchell R.E. Chai J.F. Aadahl M. Bjerregaard A.A. Yao J. Manichaikul A. Hwu C.-M. Hung Y.-J. Warren H.R. Ramirez J. Bork-Jensen J. Kårhus L.L. Goel A. Sabater-Lleal M. Noordam R. Mauro P. Matteo F. McDaid A.F. Marques-Vidal P. Wielscher M. Trompet S. Sattar N. Møllehave L.T. Munz M. Zeng L. Huang J. Yang B. Poveda A. Kurbasic A. Lamina C. Forer L. Scholz M. Galesloot T.E. Bradfield J.P. Ruotsalainen S.E. Daw E.W. Zmuda J.M. Mitchell J.S. Fuchsberger C. Christensen H. Brody J.A. Vazquez-Moreno M. Feitosa M.F. Wojczynski M.K. Wang Z. Preuss M.H. Mangino M. Christofidou P. Verweij N. Benjamins J.W. Engmann J. Tsao N.L. Verma A. Slieker R.C. Lo K.S. Zilhao N.R. Le P. Kleber M.E. Delgado G.E. Huo S. Ikeda D.D. Iha H. Demirkan A. Leonard H.L. Marten J. Frank M. Schmidt B. Smyth L.J. Cañadas-Garre M. Wang C. Nakatochi M. Wong A. Hutri-Kähönen N. Sim X. Xia R. Huerta-Chagoya A. Fernandez-Lopez J.C. Lyssenko V. Nongmaithem S.S. Bayyana S. Stringham H.M. Irvin M.R. Oldmeadow C. Kim H.-N. Ryu S. Timmers P.R.H.J. Arbeeva L. Dorajoo R. Lange L.A. Prasad G. Lorés-Motta L. Pauper M. Long J. Theusch E. Takeuchi F. Spracklen C.N. Loukola A. Bollepalli S. Warner S.C. Wang Y.X. Wei W.B. Nutile T. Ruggiero D. Sung Y.J. Chen S. Liu F. Yang J. Kentistou K.A. Banas B. Nardone G.G. Meidtner K. Bielak L.F. Smith J.A. Hebbar P. Farmaki A.-E. Hofer E. Lin M. Concas M.P. Vaccargiu S. van der Most P.J. Pitkänen N. Cade B.E. van der Laan S.W. Chitrala K.N. Weiss S. Bentley A.R. Doumatey A.P. Adeyemo A.A. Lee J.Y. Petersen E.R.B. Nielsen A.A. Choi H.S. Nethander M. Freitag-Wolf S. Southam L. Rayner N.W. Wang C.A. Lin S.-Y. Wang J.-S. Couture C. Lyytikäinen L.-P. Nikus K. Cuellar-Partida G. Vestergaard H. Hidalgo B. Giannakopoulou O. Cai Q. Obura M.O. van Setten J. Li X. Liang J. Tang H. Terzikhan N. Shin J.H. Jackson R.D. Reiner A.P. Martin L.W. Chen Z. Li L. Kawaguchi T. Thiery J. Bis J.C. Launer L.J. Nalls M.A. Raitakari O.T. Ichihara S. Wild S.H. Nelson C.P. Campbell H. Jäger S. Nabika T. Al-Mulla F. Niinikoski H. Braund P.S. Kolcic I. Kovacs P. Giardoglou T. Katsuya T. de Kleijn D. de Borst G.J. Kim E.K. Adams H.H.H. Ikram M.A. Zhu X. Asselbergs F.W. Kraaijeveld A.O. Beulens J.W.J. Shu X.-O. Rallidis L.S. Pedersen O. Hansen T. Mitchell P. Hewitt A.W. Kähönen M. Pérusse L. Bouchard C. Tönjes A. Chen Y.-D.I. Pennell C.E. Mori T.A. Lieb W. Franke A. Ohlsson C. Mellström D. Cho Y.S. Lee H. Yuan J.-M. Koh W.-P. Rhee S.Y. Woo J.-T. Heid I.M. Stark K.J. Zimmermann M.E. Völzke H. Homuth G. Evans M.K. Zonderman A.B. Polasek O. Pasterkamp G. Hoefer I.E. Redline S. Pahkala K. Oldehinkel A.J. Snieder H. Biino G. Schmidt R. Schmidt H. Bandinelli S. Dedoussis G. Thanaraj T.A. Kardia S.L.R. Peyser P.A. Kato N. Schulze M.B. Girotto G. Böger C.A. Jung B. Joshi P.K. Bennett D.A. De Jager P.L. Lu X. Mamakou V. Brown M. Caulfield M.J. Munroe P.B. Guo X. Ciullo M. Jonas J.B. Samani N.J. Kaprio J. Pajukanta P. Tusié-Luna T. Aguilar-Salinas C.A. Adair L.S. Bechayda S.A. de Silva H.J. Wickremasinghe A.R. Krauss R.M. Wu J.-Y. Zheng W. Hollander A.I. Bharadwaj D. Correa A. Wilson J.G. Lind L. Heng C.-K. Nelson A.E. Golightly Y.M. Wilson J.F. Penninx B. Kim H.-L. Attia J. Scott R.J. Rao D.C. Arnett D.K. Hunt S.C. Walker M. Koistinen H.A. Chandak G.R. Mercader J.M. Costanzo M.C. Jang D. Burtt N.P. Villalpando C.G. Orozco L. Fornage M. Tai E.S. van Dam R.M. Lehtimäki T. Chaturvedi N. Yokota M. Liu J. Reilly D.F. McKnight A.J. Kee F. Jöckel K.-H. McCarthy M.I. Palmer C.N.A. Vitart V. Hayward C. Simonsick E. van Duijn C.M. Jin Z.-B. Qu J. Hishigaki H. Lin X. März W. Gudnason V. Tardif J.-C. Lettre G. Hart L.M. Elders P.J.M. Damrauer S.M. Kumari M. Kivimaki M. van der Harst P. Spector T.D. Loos R.J.F. Province M.A. Parra E.J. Cruz M. Psaty B.M. Brandslund I. Pramstaller P.P. Rotimi C.N. Christensen K. Ripatti S. Widén E. Hakonarson H. Grant S.F.A. Kiemeney L.A.L.M. de Graaf J. Loeffler M. Kronenberg F. Gu D. Erdmann J. Schunkert H. Franks P.W. Linneberg A. Jukema J.W. Khera A.V. Männikkö M. Jarvelin M.-R. Kutalik Z. Francesco C. Mook-Kanamori D.O. van Dijk K.W. Watkins H. Strachan D.P. Grarup N. Sever P. Poulter N. Chuang L.-M. Rotter J.I. Dantoft T.M. Karpe F. Neville M.J. Timpson N.J. Cheng C.-Y. Wong T.-Y. Khor C.C. Li H. Sabanayagam C. Peters A. Gieger C. Hattersley A.T. Pedersen N.L. Magnusson P.K.E. Boomsma D.I. Willemsen A.H.M. Cupples L.A. van Meurs J.B.J. Ghanbari M. Gordon-Larsen P. Huang W. Kim Y.J. Tabara Y. Wareham N.J. Langenberg C. Zeggini E. Kuusisto J. Laakso M. Ingelsson E. Abecasis G. Chambers J.C. Kooner J.S. de Vries P.S. Morrison A.C. Hazelhurst S. Ramsay M. North K.E. Daviglus M. Kraft P. Martin N.G. Whitfield J.B. Abbas S. Saleheen D. Walters R.G. Holmes M.V. Black C. Smith B.H. Baras A. Justice A.E. Buring J.E. Ridker P.M. Chasman D.I. Kooperberg C. Tamiya G. Yamamoto M. van Heel D.A. Trembath R.C. Wei W.-Q. Jarvik G.P. Namjou B. Hayes M.G. Ritchie M.D. Jousilahti P. Salomaa V. Hveem K. Åsvold B.O. Kubo M. Kamatani Y. Okada Y. Murakami Y. Kim B.-J. Thorsteinsdottir U. Stefansson K. Zhang J. Chen Y.E. Ho Y.-L. Lynch J.A. Rader D.J. Tsao P.S. Chang K.-M. Cho K. O’Donnell C.J. Gaziano J.M. Wilson P.W.F. Frayling T.M. Hirschhorn J.N. Kathiresan S. Mohlke K.L. Sun Y.V. Morris A.P. Boehnke M. Brown C.D. Natarajan P. Deloukas P. Willer C.J. Assimes T.L. Peloso G.M.
author2_role	author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author author
dc.subject.none.fl_str_mv	lipid genetic predisposition genetics genome-wide association study human meta analysis phenotype pleiotropy sexual characteristics single nucleotide polymorphism Genetic Pleiotropy Genetic Predisposition to Disease Genome-Wide Association Study Humans Lipids Phenotype Polymorphism, Single Nucleotide Sex Characteristics
topic	lipid genetic predisposition genetics genome-wide association study human meta analysis phenotype pleiotropy sexual characteristics single nucleotide polymorphism Genetic Pleiotropy Genetic Predisposition to Disease Genome-Wide Association Study Humans Lipids Phenotype Polymorphism, Single Nucleotide Sex Characteristics
description	Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk. © 2022, The Author(s).
publishDate	2022
dc.date.none.fl_str_mv	2022
dc.type.none.fl_str_mv	info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion
format	article
status_str	publishedVersion
dc.identifier.none.fl_str_mv	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15957
url	https://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15957
dc.language.none.fl_str_mv	Inglés
language_invalid_str_mv	Inglés
dc.rights.none.fl_str_mv	info:eu-repo/semantics/openAccess
eu_rights_str_mv	openAccess
dc.publisher.none.fl_str_mv	BioMed Central Ltd
publisher.none.fl_str_mv	BioMed Central Ltd
dc.source.none.fl_str_mv	GENOME BIOLOGY ISSN: 14747596 reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau instname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
instname_str	Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)
reponame_str	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
collection	r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pau
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_	1869411461085790208
spelling	Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysisKanoni S.Graham S.E.Wang Y.Surakka I.Ramdas S.Clarke S.L.Bhatti K.F.Vedantam S.Winkler T.W.Locke A.E.Marouli E.Zajac G.J.M.Wu K.-H.H.Ntalla I.Hui Q.Klarin D.Hilliard A.T.Xue C.Thorleifsson G.Helgadottir A.Gudbjartsson D.F.Holm H.Olafsson I.Hwang M.Y.Han S.Akiyama M.Sakaue S.Terao C.Kanai M.Zhou W.Brumpton B.M.Rasheed H.Havulinna A.S.Veturi Y.Pacheco J.A.Rosenthal E.A.Lingren T.Feng Q.P.Kullo I.J.Narita A.Takayama J.Martin H.C.Hunt K.A.Trivedi B.Haessler J.Giulianini F.Bradford Y.Miller J.E.Campbell A.Lin K.Millwood I.Y.Rasheed A.Hindy G.Faul J.D.Zhao W.Weir D.R.Turman C.Huang H.Graff M.Choudhury A.Sengupta D.Mahajan A.Brown M.R.Zhang W.Yu K.Schmidt E.M.Pandit A.Gustafsson S.Yin X.Luan J.Zhao J.-H.Matsuda F.Jang H.-M.Yoon K.Medina-Gomez C.Pitsillides A.Hottenga J.J.Wood A.R.Ji Y.Gao Z.Haworth S.Yousri N.A.Mitchell R.E.Chai J.F.Aadahl M.Bjerregaard A.A.Yao J.Manichaikul A.Hwu C.-M.Hung Y.-J.Warren H.R.Ramirez J.Bork-Jensen J.Kårhus L.L.Goel A.Sabater-Lleal M.Noordam R.Mauro P.Matteo F.McDaid A.F.Marques-Vidal P.Wielscher M.Trompet S.Sattar N.Møllehave L.T.Munz M.Zeng L.Huang J.Yang B.Poveda A.Kurbasic A.Lamina C.Forer L.Scholz M.Galesloot T.E.Bradfield J.P.Ruotsalainen S.E.Daw E.W.Zmuda J.M.Mitchell J.S.Fuchsberger C.Christensen H.Brody J.A.Vazquez-Moreno M.Feitosa M.F.Wojczynski M.K.Wang Z.Preuss M.H.Mangino M.Christofidou P.Verweij N.Benjamins J.W.Engmann J.Tsao N.L.Verma A.Slieker R.C.Lo K.S.Zilhao N.R.Le P.Kleber M.E.Delgado G.E.Huo S.Ikeda D.D.Iha H.Demirkan A.Leonard H.L.Marten J.Frank M.Schmidt B.Smyth L.J.Cañadas-Garre M.Wang C.Nakatochi M.Wong A.Hutri-Kähönen N.Sim X.Xia R.Huerta-Chagoya A.Fernandez-Lopez J.C.Lyssenko V.Nongmaithem S.S.Bayyana S.Stringham H.M.Irvin M.R.Oldmeadow C.Kim H.-N.Ryu S.Timmers P.R.H.J.Arbeeva L.Dorajoo R.Lange L.A.Prasad G.Lorés-Motta L.Pauper M.Long J.Theusch E.Takeuchi F.Spracklen C.N.Loukola A.Bollepalli S.Warner S.C.Wang Y.X.Wei W.B.Nutile T.Ruggiero D.Sung Y.J.Chen S.Liu F.Yang J.Kentistou K.A.Banas B.Nardone G.G.Meidtner K.Bielak L.F.Smith J.A.Hebbar P.Farmaki A.-E.Hofer E.Lin M.Concas M.P.Vaccargiu S.van der Most P.J.Pitkänen N.Cade B.E.van der Laan S.W.Chitrala K.N.Weiss S.Bentley A.R.Doumatey A.P.Adeyemo A.A.Lee J.Y.Petersen E.R.B.Nielsen A.A.Choi H.S.Nethander M.Freitag-Wolf S.Southam L.Rayner N.W.Wang C.A.Lin S.-Y.Wang J.-S.Couture C.Lyytikäinen L.-P.Nikus K.Cuellar-Partida G.Vestergaard H.Hidalgo B.Giannakopoulou O.Cai Q.Obura M.O.van Setten J.Li X.Liang J.Tang H.Terzikhan N.Shin J.H.Jackson R.D.Reiner A.P.Martin L.W.Chen Z.Li L.Kawaguchi T.Thiery J.Bis J.C.Launer L.J.Nalls M.A.Raitakari O.T.Ichihara S.Wild S.H.Nelson C.P.Campbell H.Jäger S.Nabika T.Al-Mulla F.Niinikoski H.Braund P.S.Kolcic I.Kovacs P.Giardoglou T.Katsuya T.de Kleijn D.de Borst G.J.Kim E.K.Adams H.H.H.Ikram M.A.Zhu X.Asselbergs F.W.Kraaijeveld A.O.Beulens J.W.J.Shu X.-O.Rallidis L.S.Pedersen O.Hansen T.Mitchell P.Hewitt A.W.Kähönen M.Pérusse L.Bouchard C.Tönjes A.Chen Y.-D.I.Pennell C.E.Mori T.A.Lieb W.Franke A.Ohlsson C.Mellström D.Cho Y.S.Lee H.Yuan J.-M.Koh W.-P.Rhee S.Y.Woo J.-T.Heid I.M.Stark K.J.Zimmermann M.E.Völzke H.Homuth G.Evans M.K.Zonderman A.B.Polasek O.Pasterkamp G.Hoefer I.E.Redline S.Pahkala K.Oldehinkel A.J.Snieder H.Biino G.Schmidt R.Schmidt H.Bandinelli S.Dedoussis G.Thanaraj T.A.Kardia S.L.R.Peyser P.A.Kato N.Schulze M.B.Girotto G.Böger C.A.Jung B.Joshi P.K.Bennett D.A.De Jager P.L.Lu X.Mamakou V.Brown M.Caulfield M.J.Munroe P.B.Guo X.Ciullo M.Jonas J.B.Samani N.J.Kaprio J.Pajukanta P.Tusié-Luna T.Aguilar-Salinas C.A.Adair L.S.Bechayda S.A.de Silva H.J.Wickremasinghe A.R.Krauss R.M.Wu J.-Y.Zheng W.Hollander A.I.Bharadwaj D.Correa A.Wilson J.G.Lind L.Heng C.-K.Nelson A.E.Golightly Y.M.Wilson J.F.Penninx B.Kim H.-L.Attia J.Scott R.J.Rao D.C.Arnett D.K.Hunt S.C.Walker M.Koistinen H.A.Chandak G.R.Mercader J.M.Costanzo M.C.Jang D.Burtt N.P.Villalpando C.G.Orozco L.Fornage M.Tai E.S.van Dam R.M.Lehtimäki T.Chaturvedi N.Yokota M.Liu J.Reilly D.F.McKnight A.J.Kee F.Jöckel K.-H.McCarthy M.I.Palmer C.N.A.Vitart V.Hayward C.Simonsick E.van Duijn C.M.Jin Z.-B.Qu J.Hishigaki H.Lin X.März W.Gudnason V.Tardif J.-C.Lettre G.Hart L.M.Elders P.J.M.Damrauer S.M.Kumari M.Kivimaki M.van der Harst P.Spector T.D.Loos R.J.F.Province M.A.Parra E.J.Cruz M.Psaty B.M.Brandslund I.Pramstaller P.P.Rotimi C.N.Christensen K.Ripatti S.Widén E.Hakonarson H.Grant S.F.A.Kiemeney L.A.L.M.de Graaf J.Loeffler M.Kronenberg F.Gu D.Erdmann J.Schunkert H.Franks P.W.Linneberg A.Jukema J.W.Khera A.V.Männikkö M.Jarvelin M.-R.Kutalik Z.Francesco C.Mook-Kanamori D.O.van Dijk K.W.Watkins H.Strachan D.P.Grarup N.Sever P.Poulter N.Chuang L.-M.Rotter J.I.Dantoft T.M.Karpe F.Neville M.J.Timpson N.J.Cheng C.-Y.Wong T.-Y.Khor C.C.Li H.Sabanayagam C.Peters A.Gieger C.Hattersley A.T.Pedersen N.L.Magnusson P.K.E.Boomsma D.I.Willemsen A.H.M.Cupples L.A.van Meurs J.B.J.Ghanbari M.Gordon-Larsen P.Huang W.Kim Y.J.Tabara Y.Wareham N.J.Langenberg C.Zeggini E.Kuusisto J.Laakso M.Ingelsson E.Abecasis G.Chambers J.C.Kooner J.S.de Vries P.S.Morrison A.C.Hazelhurst S.Ramsay M.North K.E.Daviglus M.Kraft P.Martin N.G.Whitfield J.B.Abbas S.Saleheen D.Walters R.G.Holmes M.V.Black C.Smith B.H.Baras A.Justice A.E.Buring J.E.Ridker P.M.Chasman D.I.Kooperberg C.Tamiya G.Yamamoto M.van Heel D.A.Trembath R.C.Wei W.-Q.Jarvik G.P.Namjou B.Hayes M.G.Ritchie M.D.Jousilahti P.Salomaa V.Hveem K.Åsvold B.O.Kubo M.Kamatani Y.Okada Y.Murakami Y.Kim B.-J.Thorsteinsdottir U.Stefansson K.Zhang J.Chen Y.E.Ho Y.-L.Lynch J.A.Rader D.J.Tsao P.S.Chang K.-M.Cho K.O’Donnell C.J.Gaziano J.M.Wilson P.W.F.Frayling T.M.Hirschhorn J.N.Kathiresan S.Mohlke K.L.Sun Y.V.Morris A.P.Boehnke M.Brown C.D.Natarajan P.Deloukas P.Willer C.J.Assimes T.L.Peloso G.M.lipidgenetic predispositiongeneticsgenome-wide association studyhumanmeta analysisphenotypepleiotropysexual characteristicssingle nucleotide polymorphismGenetic PleiotropyGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLipidsPhenotypePolymorphism, Single NucleotideSex CharacteristicsBackground: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk. © 2022, The Author(s).BioMed Central Ltd2022info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://iibsantpau.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=15957GENOME BIOLOGYISSN: 14747596reponame:r-IIB SANT PAU. Repositorio Institucional de Producción Científica del Instituto de Investigación Biomédica Sant Pauinstname:Institut d’Investigació Biomèdica Sant Pau (IIB Sant Pau)Inglésinfo:eu-repo/semantics/openAccessoai:iibsantpau.fundanetsuite.com:p159572026-06-14T12:41:47Z
score	15.811543

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis

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