CLA+ memory T cells in atopic dermatitis CLA plus T cells and atopic dermatitis

Circulating skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells constitute a small subset of human memory T cells involved in several aspects of atopic dermatitis: Staphylococcus aureus related mechanisms, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients,...

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Autores: Sans de San Nicolàs, Lídia, Czarnowicki, Tali, Akdis, Mubeccel, Pujol, Ramon M., Lozano-Ojalvo, Daniel, Leung, Donald Y. M., Guttman-Yassky, Emma, Santamaria Babí, Luis F.
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2023
País:España
Institución:Universidad de Barcelona
Repositorio:Dipòsit Digital de la UB
OAI Identifier:oai:diposit.ub.edu:2445/222655
Acceso en línea:https://hdl.handle.net/2445/222655
Access Level:acceso abierto
Palabra clave:Marcadors bioquímics
Dermatitis atòpica
Cèl·lules T
Biochemical markers
Atopic dermatitis
T cells
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spelling CLA+ memory T cells in atopic dermatitis CLA plus T cells and atopic dermatitisSans de San Nicolàs, LídiaCzarnowicki, TaliAkdis, MubeccelPujol, Ramon M.Lozano-Ojalvo, DanielLeung, Donald Y. M.Guttman-Yassky, EmmaSantamaria Babí, Luis F.Marcadors bioquímicsDermatitis atòpicaCèl·lules TBiochemical markersAtopic dermatitisT cellsCirculating skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells constitute a small subset of human memory T cells involved in several aspects of atopic dermatitis: Staphylococcus aureus related mechanisms, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients, pruritus, and the mechanism of action of targeted therapies. Superantigens, IL-13, IL-31, pruritus, CCL17 and early effects on dupilumab-treated patients have in common that they are associated with the CLA+ T cell mechanisms in atopic dermatitis patients. The function of CLA+ T cells corresponds with the role of T cells belonging to the skin-associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis and many other T cell mediated skin diseases. The goal of this review is to gather all this translational information of atopic dermatitis pathology.John Wiley & Sons2023info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://hdl.handle.net/2445/222655Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)reponame:Dipòsit Digital de la UBinstname:Universidad de BarcelonaInglésReproducció del document publicat a: https://doi.org/10.1111/all.15816Allergy, 2024, vol. 79, num.1, p. 15-25https://doi.org/10.1111/all.15816cc by-nc 4.0 (c) Sans-de San Nicolàs, L., et al., 2024https://creativecommons.org/licenses/by-nc/4.0/info:eu-repo/semantics/openAccessoai:diposit.ub.edu:2445/2226552026-05-27T06:46:51Z
dc.title.none.fl_str_mv CLA+ memory T cells in atopic dermatitis CLA plus T cells and atopic dermatitis
title CLA+ memory T cells in atopic dermatitis CLA plus T cells and atopic dermatitis
spellingShingle CLA+ memory T cells in atopic dermatitis CLA plus T cells and atopic dermatitis
Sans de San Nicolàs, Lídia
Marcadors bioquímics
Dermatitis atòpica
Cèl·lules T
Biochemical markers
Atopic dermatitis
T cells
title_short CLA+ memory T cells in atopic dermatitis CLA plus T cells and atopic dermatitis
title_full CLA+ memory T cells in atopic dermatitis CLA plus T cells and atopic dermatitis
title_fullStr CLA+ memory T cells in atopic dermatitis CLA plus T cells and atopic dermatitis
title_full_unstemmed CLA+ memory T cells in atopic dermatitis CLA plus T cells and atopic dermatitis
title_sort CLA+ memory T cells in atopic dermatitis CLA plus T cells and atopic dermatitis
dc.creator.none.fl_str_mv Sans de San Nicolàs, Lídia
Czarnowicki, Tali
Akdis, Mubeccel
Pujol, Ramon M.
Lozano-Ojalvo, Daniel
Leung, Donald Y. M.
Guttman-Yassky, Emma
Santamaria Babí, Luis F.
author Sans de San Nicolàs, Lídia
author_facet Sans de San Nicolàs, Lídia
Czarnowicki, Tali
Akdis, Mubeccel
Pujol, Ramon M.
Lozano-Ojalvo, Daniel
Leung, Donald Y. M.
Guttman-Yassky, Emma
Santamaria Babí, Luis F.
author_role author
author2 Czarnowicki, Tali
Akdis, Mubeccel
Pujol, Ramon M.
Lozano-Ojalvo, Daniel
Leung, Donald Y. M.
Guttman-Yassky, Emma
Santamaria Babí, Luis F.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Marcadors bioquímics
Dermatitis atòpica
Cèl·lules T
Biochemical markers
Atopic dermatitis
T cells
topic Marcadors bioquímics
Dermatitis atòpica
Cèl·lules T
Biochemical markers
Atopic dermatitis
T cells
description Circulating skin-homing cutaneous lymphocyte-associated antigen (CLA)+ T cells constitute a small subset of human memory T cells involved in several aspects of atopic dermatitis: Staphylococcus aureus related mechanisms, the abnormal Th2 immune response, biomarkers, clinical aspects of the patients, pruritus, and the mechanism of action of targeted therapies. Superantigens, IL-13, IL-31, pruritus, CCL17 and early effects on dupilumab-treated patients have in common that they are associated with the CLA+ T cell mechanisms in atopic dermatitis patients. The function of CLA+ T cells corresponds with the role of T cells belonging to the skin-associated lymphoid tissue and could be a reason why they reflect different mechanisms of atopic dermatitis and many other T cell mediated skin diseases. The goal of this review is to gather all this translational information of atopic dermatitis pathology.
publishDate 2023
dc.date.none.fl_str_mv 2023
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/222655
url https://hdl.handle.net/2445/222655
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1111/all.15816
Allergy, 2024, vol. 79, num.1, p. 15-25
https://doi.org/10.1111/all.15816
dc.rights.none.fl_str_mv cc by-nc 4.0 (c) Sans-de San Nicolàs, L., et al., 2024
https://creativecommons.org/licenses/by-nc/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc by-nc 4.0 (c) Sans-de San Nicolàs, L., et al., 2024
https://creativecommons.org/licenses/by-nc/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons
publisher.none.fl_str_mv John Wiley & Sons
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
reponame:Dipòsit Digital de la UB
instname:Universidad de Barcelona
instname_str Universidad de Barcelona
reponame_str Dipòsit Digital de la UB
collection Dipòsit Digital de la UB
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,812429

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