Risk of severe cardiovascular events following COPD exacerbations: results from the EXACOS-CV study in Spain

Introduction and objectives: This real-world study-the first of its kind in a Spanish population-aimed to explore severe risk for cardiovascular events and all-cause death following exacerbations in a large cohort of patients with chronic obstructive pulmonary disease (COPD). Methods: We included in...

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Authors: Santos Pérez, Salud, Manito Lorite, Nicolás, Sánchez-Covisa, Joaquín, Hernández, Ignacio, Corregidor, Carmen, Escudero Herrera, Luciano, Rhodes, Kirsty, Nordon, Clementine
Format: article
Status:Published version
Publication Date:2024
Country:España
Institution:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repository:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/220639
Online Access:https://hdl.handle.net/2445/220639
Access Level:Open access
Keyword:Mortalitat
Malalties pulmonars obstructives cròniques
Malalties cardiovasculars
Mortality
Chronic obstructive pulmonary diseases
Cardiovascular diseases
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spelling Risk of severe cardiovascular events following COPD exacerbations: results from the EXACOS-CV study in SpainSantos Pérez, SaludManito Lorite, NicolásSánchez-Covisa, JoaquínHernández, IgnacioCorregidor, CarmenEscudero Herrera, LucianoRhodes, KirstyNordon, ClementineMortalitatMalalties pulmonars obstructives cròniquesMalalties cardiovascularsMortalityChronic obstructive pulmonary diseasesCardiovascular diseasesIntroduction and objectives: This real-world study-the first of its kind in a Spanish population-aimed to explore severe risk for cardiovascular events and all-cause death following exacerbations in a large cohort of patients with chronic obstructive pulmonary disease (COPD). Methods: We included individuals with a COPD diagnosis code between 2014 and 2018 from the BIG-PAC health care claims database. The primary outcome was a composite of a first severe cardiovascular event (acute coronary syndrome, heart failure decompensation, cerebral ischemia, arrhythmia) or all-cause death following inclusion in the cohort. Time-dependent Cox proportional hazards models estimated HRs for associations between exposed time periods (1-7, 8-14, 15-30, 31-180, 181-365, and >365 days) following an exacerbation of any severity, and following moderate or severe exacerbations separately (vs unexposed time before a first exacerbation following cohort inclusion). Results: During a median follow-up of 3.03 years, 18 901 of 24 393 patients (77.5%) experienced ≥ 1 moderate/severe exacerbation, and 8741 (35.8%) experienced the primary outcome. The risk of a severe cardiovascular event increased following moderate/severe COPD exacerbation onset vs the unexposed period, with rates being most increased during the first 1 to 7 days following exacerbation onset (HR, 10.10; 95%CI, 9.29-10.97) and remaining increased >365 days after exacerbation onset (HR, 1.65; 95%CI, 1.49-1.82). Conclusions: The risk of severe cardiovascular events or death increased following moderate/severe exacerbation onset, illustrating the need for proactive multidisciplinary care of patients with COPD to prevent exacerbations and address other cardiovascular risk factors.Elsevier España2025202520242025info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion13 p.application/pdfhttps://hdl.handle.net/2445/220639Articles publicats en revistes (Ciències Clíniques)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.1016/j.rec.2024.06.003Revista Española de Cardiología, 2024, vol. 78, num.2, p. 138-150https://doi.org/10.1016/j.rec.2024.06.003cc-by-nc-nd (c) Santos Pérez, Salud et al., 2024https://creativecommons.org/licenses/by-nc-nd/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2206392026-05-29T05:05:01Z
dc.title.none.fl_str_mv Risk of severe cardiovascular events following COPD exacerbations: results from the EXACOS-CV study in Spain
title Risk of severe cardiovascular events following COPD exacerbations: results from the EXACOS-CV study in Spain
spellingShingle Risk of severe cardiovascular events following COPD exacerbations: results from the EXACOS-CV study in Spain
Santos Pérez, Salud
Mortalitat
Malalties pulmonars obstructives cròniques
Malalties cardiovasculars
Mortality
Chronic obstructive pulmonary diseases
Cardiovascular diseases
title_short Risk of severe cardiovascular events following COPD exacerbations: results from the EXACOS-CV study in Spain
title_full Risk of severe cardiovascular events following COPD exacerbations: results from the EXACOS-CV study in Spain
title_fullStr Risk of severe cardiovascular events following COPD exacerbations: results from the EXACOS-CV study in Spain
title_full_unstemmed Risk of severe cardiovascular events following COPD exacerbations: results from the EXACOS-CV study in Spain
title_sort Risk of severe cardiovascular events following COPD exacerbations: results from the EXACOS-CV study in Spain
dc.creator.none.fl_str_mv Santos Pérez, Salud
Manito Lorite, Nicolás
Sánchez-Covisa, Joaquín
Hernández, Ignacio
Corregidor, Carmen
Escudero Herrera, Luciano
Rhodes, Kirsty
Nordon, Clementine
author Santos Pérez, Salud
author_facet Santos Pérez, Salud
Manito Lorite, Nicolás
Sánchez-Covisa, Joaquín
Hernández, Ignacio
Corregidor, Carmen
Escudero Herrera, Luciano
Rhodes, Kirsty
Nordon, Clementine
author_role author
author2 Manito Lorite, Nicolás
Sánchez-Covisa, Joaquín
Hernández, Ignacio
Corregidor, Carmen
Escudero Herrera, Luciano
Rhodes, Kirsty
Nordon, Clementine
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mortalitat
Malalties pulmonars obstructives cròniques
Malalties cardiovasculars
Mortality
Chronic obstructive pulmonary diseases
Cardiovascular diseases
topic Mortalitat
Malalties pulmonars obstructives cròniques
Malalties cardiovasculars
Mortality
Chronic obstructive pulmonary diseases
Cardiovascular diseases
description Introduction and objectives: This real-world study-the first of its kind in a Spanish population-aimed to explore severe risk for cardiovascular events and all-cause death following exacerbations in a large cohort of patients with chronic obstructive pulmonary disease (COPD). Methods: We included individuals with a COPD diagnosis code between 2014 and 2018 from the BIG-PAC health care claims database. The primary outcome was a composite of a first severe cardiovascular event (acute coronary syndrome, heart failure decompensation, cerebral ischemia, arrhythmia) or all-cause death following inclusion in the cohort. Time-dependent Cox proportional hazards models estimated HRs for associations between exposed time periods (1-7, 8-14, 15-30, 31-180, 181-365, and >365 days) following an exacerbation of any severity, and following moderate or severe exacerbations separately (vs unexposed time before a first exacerbation following cohort inclusion). Results: During a median follow-up of 3.03 years, 18 901 of 24 393 patients (77.5%) experienced ≥ 1 moderate/severe exacerbation, and 8741 (35.8%) experienced the primary outcome. The risk of a severe cardiovascular event increased following moderate/severe COPD exacerbation onset vs the unexposed period, with rates being most increased during the first 1 to 7 days following exacerbation onset (HR, 10.10; 95%CI, 9.29-10.97) and remaining increased >365 days after exacerbation onset (HR, 1.65; 95%CI, 1.49-1.82). Conclusions: The risk of severe cardiovascular events or death increased following moderate/severe exacerbation onset, illustrating the need for proactive multidisciplinary care of patients with COPD to prevent exacerbations and address other cardiovascular risk factors.
publishDate 2024
dc.date.none.fl_str_mv 2024
2025
2025
2025
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/220639
url https://hdl.handle.net/2445/220639
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1016/j.rec.2024.06.003
Revista Española de Cardiología, 2024, vol. 78, num.2, p. 138-150
https://doi.org/10.1016/j.rec.2024.06.003
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Santos Pérez, Salud et al., 2024
https://creativecommons.org/licenses/by-nc-nd/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Santos Pérez, Salud et al., 2024
https://creativecommons.org/licenses/by-nc-nd/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 13 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier España
publisher.none.fl_str_mv Elsevier España
dc.source.none.fl_str_mv Articles publicats en revistes (Ciències Clíniques)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411447448010752
score 15,811543

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