On the protective role of the blood vessels in glaucomatous damage: A transversal study
Purpose: To corroborate whether vessels on the surface of the optic nerve head can provide pro- tection against the loss of underlying axons in subjects with manifest glaucoma. Methods: In this pilot study, thirty-six glaucomatous eyes with a perimetric defect in the Bjerrum area were included. The...
| Autores: | , , , , |
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| Tipo de recurso: | artículo |
| Fecha de publicación: | 2023 |
| País: | España |
| Institución: | Universidad Católica San Antonio de Murcia (UCAM) |
| Repositorio: | RIUCAM. Repositorio Institucional de la Universidad Católica San Antonio de Murcia |
| OAI Identifier: | oai:repositorio.ucam.edu:10952/7311 |
| Acceso en línea: | http://hdl.handle.net/10952/7311 |
| Access Level: | acceso abierto |
| Palabra clave: | Astrocytes Visual field Primary open-angle glaucoma Aqueous humor Blood vessel |
| Sumario: | Purpose: To corroborate whether vessels on the surface of the optic nerve head can provide pro- tection against the loss of underlying axons in subjects with manifest glaucoma. Methods: In this pilot study, thirty-six glaucomatous eyes with a perimetric defect in the Bjerrum area were included. The retinal nerve fiber layer (RNFL) thickness was measured in each of the sectors of the clock-hour map obtained by Cirrus HD-OCT considering the presence or absence of blood vessels. These sectors were related with their corresponding areas of the retina examined in the visual field using a mathematical model of the retina introduced by Jansonius, in order to determine the values of threshold sensitivity in those areas in the presence or absence of vessels. Results: We corroborated the protective role of the blood vessel for peripapillary RNFL thickness of clock-hour 12 despite obtaining a p-value (p = 0.023; w = 228.5) close to the acceptance zone (p 0.05). The mean § standard deviation with vessel and without vessel were 70.95 § 24.35 and 88.46 § 23.96, respectively. No differences were found between the mean values of thresh-old sensitivity to the presence or absence of blood vessels in each of the sectors considered. Conclusions: Our findings do not allow us to affirm that there is an association between the pres- ence of a vessel and protection against glaucomatous damage in subjects with an advanced man- ifestation of the disease. In the future, more extensive studies are needed to study this relationship in subjects with early glaucoma. |
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