Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-Analysis

Triplet pregnancies are rare events that affect approximately 93 in 100,000 deliveries in the world, especially due to the increased use of assisted reproductive techniques and older maternal age. Triplet pregnancies are associated with a higher risk of fetal and maternal morbidity and mortality com...

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Detalhes bibliográficos
Autores: Bernal Claverol, Mireia, Ruiz Minaya, Maria, Aracil Moreno, Irene, García Tizón, Santiago, Pintado Recarte, María Del Pilar, Álvarez Mon, Melchor, Bravo Arribas, Coral, Ortega, Miguel A., León Luis, Juan Antonio
Formato: artículo
Fecha de publicación:2022
País:España
Recursos:Universidad Complutense de Madrid (UCM)
Repositorio:Docta Complutense
Idioma:inglés
OAI Identifier:oai:docta.ucm.es:20.500.14352/73380
Acesso em linha:https://hdl.handle.net/20.500.14352/73380
Access Level:acceso abierto
Palavra-chave:618.2
Triplet pregnancies
Chorionicity
Trichorionic triamniotic (TCTA)
Neonatal complications
Maternal outcomes
Perinatal outcomes
Medicina
Ginecología y obstetricia
32 Ciencias Médicas
3201.08 Ginecología
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oai_identifier_str oai:docta.ucm.es:20.500.14352/73380
network_acronym_str ES
network_name_str España
repository_id_str
spelling Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-AnalysisBernal Claverol, MireiaRuiz Minaya, MariaAracil Moreno, IreneGarcía Tizón, SantiagoPintado Recarte, María Del PilarÁlvarez Mon, MelchorBravo Arribas, CoralOrtega, Miguel A.León Luis, Juan Antonio618.2Triplet pregnanciesChorionicityTrichorionic triamniotic (TCTA)Neonatal complicationsMaternal outcomesPerinatal outcomesMedicinaGinecología y obstetricia32 Ciencias Médicas3201.08 GinecologíaTriplet pregnancies are rare events that affect approximately 93 in 100,000 deliveries in the world, especially due to the increased use of assisted reproductive techniques and older maternal age. Triplet pregnancies are associated with a higher risk of fetal and maternal morbidity and mortality compared to twins and singletons. Chorionicity has been proposed as a major determinant of perinatal and maternal outcomes in triplet pregnancies, although further evidence is needed to clarify the extent and real influence of this factor. Thus, the aim of this study was to conduct a systematic review of the literature and a meta-analysis of the maternal and perinatal outcomes of triplet pregnancies, evaluating how chorionicity may influence these results. A total of 46 studies with 43,653 triplet pregnancies and 128,145 live births were included. Among the main results of our study, we found a broad spectrum of fetal and maternal complications, especially in the group of monochorionic and dichorionic pregnancies. Risk of admission to NICU, respiratory distress, sepsis, necrotizing enterocolitis, perinatal and intrauterine mortality were all found to be higher in non-TCTA pregnancies than in TCTA pregnancies. To date, our meta-analysis includes the largest population sample and number of studies conducted in this field, evaluating a wide variety of outcome measures. The heterogeneity and retrospective design of the studies included in our research represent the main limitations of this review. More evidence is needed to fully assess outcome measures that could not be studied in this review due to scarcity of publications or insufficient sample size.MDPIUniversidad Complutense de Madrid20222022-03-2820222022-03-28journal articlehttp://purl.org/coar/resource_type/c_6501info:eu-repo/semantics/articleapplication/pdfhttps://hdl.handle.net/20.500.14352/73380reponame:Docta Complutenseinstname:Universidad Complutense de Madrid (UCM)Inglésengopen accesshttp://purl.org/coar/access_right/c_abf2Atribución 3.0 Españahttps://creativecommons.org/licenses/by/3.0/es/info:eu-repo/semantics/openAccessoai:docta.ucm.es:20.500.14352/733802026-06-02T12:44:21Z
dc.title.none.fl_str_mv Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-Analysis
title Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-Analysis
spellingShingle Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-Analysis
Bernal Claverol, Mireia
618.2
Triplet pregnancies
Chorionicity
Trichorionic triamniotic (TCTA)
Neonatal complications
Maternal outcomes
Perinatal outcomes
Medicina
Ginecología y obstetricia
32 Ciencias Médicas
3201.08 Ginecología
title_short Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-Analysis
title_full Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-Analysis
title_fullStr Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-Analysis
title_full_unstemmed Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-Analysis
title_sort Maternal, Perinatal and Neonatal Outcomes of Triplet Pregnancies According to Chorionicity: A Systematic Review of the Literature and Meta-Analysis
dc.creator.none.fl_str_mv Bernal Claverol, Mireia
Ruiz Minaya, Maria
Aracil Moreno, Irene
García Tizón, Santiago
Pintado Recarte, María Del Pilar
Álvarez Mon, Melchor
Bravo Arribas, Coral
Ortega, Miguel A.
León Luis, Juan Antonio
author Bernal Claverol, Mireia
author_facet Bernal Claverol, Mireia
Ruiz Minaya, Maria
Aracil Moreno, Irene
García Tizón, Santiago
Pintado Recarte, María Del Pilar
Álvarez Mon, Melchor
Bravo Arribas, Coral
Ortega, Miguel A.
León Luis, Juan Antonio
author_role author
author2 Ruiz Minaya, Maria
Aracil Moreno, Irene
García Tizón, Santiago
Pintado Recarte, María Del Pilar
Álvarez Mon, Melchor
Bravo Arribas, Coral
Ortega, Miguel A.
León Luis, Juan Antonio
author2_role author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidad Complutense de Madrid
dc.subject.none.fl_str_mv 618.2
Triplet pregnancies
Chorionicity
Trichorionic triamniotic (TCTA)
Neonatal complications
Maternal outcomes
Perinatal outcomes
Medicina
Ginecología y obstetricia
32 Ciencias Médicas
3201.08 Ginecología
topic 618.2
Triplet pregnancies
Chorionicity
Trichorionic triamniotic (TCTA)
Neonatal complications
Maternal outcomes
Perinatal outcomes
Medicina
Ginecología y obstetricia
32 Ciencias Médicas
3201.08 Ginecología
description Triplet pregnancies are rare events that affect approximately 93 in 100,000 deliveries in the world, especially due to the increased use of assisted reproductive techniques and older maternal age. Triplet pregnancies are associated with a higher risk of fetal and maternal morbidity and mortality compared to twins and singletons. Chorionicity has been proposed as a major determinant of perinatal and maternal outcomes in triplet pregnancies, although further evidence is needed to clarify the extent and real influence of this factor. Thus, the aim of this study was to conduct a systematic review of the literature and a meta-analysis of the maternal and perinatal outcomes of triplet pregnancies, evaluating how chorionicity may influence these results. A total of 46 studies with 43,653 triplet pregnancies and 128,145 live births were included. Among the main results of our study, we found a broad spectrum of fetal and maternal complications, especially in the group of monochorionic and dichorionic pregnancies. Risk of admission to NICU, respiratory distress, sepsis, necrotizing enterocolitis, perinatal and intrauterine mortality were all found to be higher in non-TCTA pregnancies than in TCTA pregnancies. To date, our meta-analysis includes the largest population sample and number of studies conducted in this field, evaluating a wide variety of outcome measures. The heterogeneity and retrospective design of the studies included in our research represent the main limitations of this review. More evidence is needed to fully assess outcome measures that could not be studied in this review due to scarcity of publications or insufficient sample size.
publishDate 2022
dc.date.none.fl_str_mv 2022
2022-03-28
2022
2022-03-28
dc.type.none.fl_str_mv journal article
http://purl.org/coar/resource_type/c_6501
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://hdl.handle.net/20.500.14352/73380
url https://hdl.handle.net/20.500.14352/73380
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
Atribución 3.0 España
https://creativecommons.org/licenses/by/3.0/es/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv reponame:Docta Complutense
instname:Universidad Complutense de Madrid (UCM)
instname_str Universidad Complutense de Madrid (UCM)
reponame_str Docta Complutense
collection Docta Complutense
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15,300719

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