Impact of Hydroxytyrosol-Rich Extract Supplementation in a High-Fat Diet on Gilthead Sea Bream (Sparus aurata) Lipid Metabolism

High-fat diets (HFDs) enhance fish growth by optimizing nutrient utilization (i.e., protein-sparing effect); however, their potential negative effects have also encouraged the search for feed additives. This work has investigated the effects of an extract rich in a polyphenolic antioxidant, hydroxyt...

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Autores: Balbuena-Pecino, Sara, Montblanch, Manel, Rosell-Moll, Enrique, González-Fernández, Verónica, García Meilán, Irene, Fontanillas, Ramon, Gallardo Romero, María Ángeles, Gutiérrez Fruitós, Joaquín, Capilla Campos, Encarnación, Navarro Álvarez, Isabel
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositorio:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/214628
Acceso en línea:https://hdl.handle.net/2445/214628
Access Level:acceso abierto
Palabra clave:Orada
Polifenols
Metabolisme dels lípids
Additius de pinsos
Sparus aurata
Polyphenols
Lipid metabolism
Feed additives
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spelling Impact of Hydroxytyrosol-Rich Extract Supplementation in a High-Fat Diet on Gilthead Sea Bream (Sparus aurata) Lipid MetabolismBalbuena-Pecino, SaraMontblanch, ManelRosell-Moll, EnriqueGonzález-Fernández, VerónicaGarcía Meilán, IreneFontanillas, RamonGallardo Romero, María ÁngelesGutiérrez Fruitós, JoaquínCapilla Campos, EncarnaciónNavarro Álvarez, IsabelOradaPolifenolsMetabolisme dels lípidsAdditius de pinsosSparus aurataPolyphenolsLipid metabolismFeed additivesHigh-fat diets (HFDs) enhance fish growth by optimizing nutrient utilization (i.e., protein-sparing effect); however, their potential negative effects have also encouraged the search for feed additives. This work has investigated the effects of an extract rich in a polyphenolic antioxidant, hydroxytyrosol (HT), supplemented (0.52 g HT/kg feed) in a HFD (24% lipid) in gilthead sea bream (Sparus aurata). Fish received the diet at two ration levels, standard (3% of total fish weight) or restricted (40% reduction) for 8 weeks. Animals fed the supplemented diet at a standard ration had the lowest levels of plasma free fatty acids (4.28 ± 0.23 mg/dL versus 6.42 ± 0.47 in the non-supplemented group) and downregulated hepatic mRNA levels of lipid metabolism markers (ppara, pparb, lpl, fatp1, fabp1, acox1, lipe and lipa), supporting potential fat-lowering properties of this compound in the liver. Moreover, the same animals showed increased muscle lipid content and peroxidation (1.58- and 1.22-fold, respectively, compared to the fish without HT), suggesting the modulation of body adiposity distribution and an enhanced lipid oxidation rate in that tissue. Our findings emphasize the importance of considering this phytocompound as an optimal additive in HFDs for gilthead sea bream to improve overall fish health and condition.MDPI2024202420242024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion21 p.application/pdfhttps://hdl.handle.net/2445/214628Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésReproducció del document publicat a: https://doi.org/10.3390/antiox13040403Antioxidants, 2024, vol. 13, num.4, p. 1-21https://doi.org/10.3390/antiox13040403cc-by (c) Balbuena-Pecino, S. et al., 2024http://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:recercat.cat:2445/2146282026-05-29T05:05:01Z
dc.title.none.fl_str_mv Impact of Hydroxytyrosol-Rich Extract Supplementation in a High-Fat Diet on Gilthead Sea Bream (Sparus aurata) Lipid Metabolism
title Impact of Hydroxytyrosol-Rich Extract Supplementation in a High-Fat Diet on Gilthead Sea Bream (Sparus aurata) Lipid Metabolism
spellingShingle Impact of Hydroxytyrosol-Rich Extract Supplementation in a High-Fat Diet on Gilthead Sea Bream (Sparus aurata) Lipid Metabolism
Balbuena-Pecino, Sara
Orada
Polifenols
Metabolisme dels lípids
Additius de pinsos
Sparus aurata
Polyphenols
Lipid metabolism
Feed additives
title_short Impact of Hydroxytyrosol-Rich Extract Supplementation in a High-Fat Diet on Gilthead Sea Bream (Sparus aurata) Lipid Metabolism
title_full Impact of Hydroxytyrosol-Rich Extract Supplementation in a High-Fat Diet on Gilthead Sea Bream (Sparus aurata) Lipid Metabolism
title_fullStr Impact of Hydroxytyrosol-Rich Extract Supplementation in a High-Fat Diet on Gilthead Sea Bream (Sparus aurata) Lipid Metabolism
title_full_unstemmed Impact of Hydroxytyrosol-Rich Extract Supplementation in a High-Fat Diet on Gilthead Sea Bream (Sparus aurata) Lipid Metabolism
title_sort Impact of Hydroxytyrosol-Rich Extract Supplementation in a High-Fat Diet on Gilthead Sea Bream (Sparus aurata) Lipid Metabolism
dc.creator.none.fl_str_mv Balbuena-Pecino, Sara
Montblanch, Manel
Rosell-Moll, Enrique
González-Fernández, Verónica
García Meilán, Irene
Fontanillas, Ramon
Gallardo Romero, María Ángeles
Gutiérrez Fruitós, Joaquín
Capilla Campos, Encarnación
Navarro Álvarez, Isabel
author Balbuena-Pecino, Sara
author_facet Balbuena-Pecino, Sara
Montblanch, Manel
Rosell-Moll, Enrique
González-Fernández, Verónica
García Meilán, Irene
Fontanillas, Ramon
Gallardo Romero, María Ángeles
Gutiérrez Fruitós, Joaquín
Capilla Campos, Encarnación
Navarro Álvarez, Isabel
author_role author
author2 Montblanch, Manel
Rosell-Moll, Enrique
González-Fernández, Verónica
García Meilán, Irene
Fontanillas, Ramon
Gallardo Romero, María Ángeles
Gutiérrez Fruitós, Joaquín
Capilla Campos, Encarnación
Navarro Álvarez, Isabel
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Orada
Polifenols
Metabolisme dels lípids
Additius de pinsos
Sparus aurata
Polyphenols
Lipid metabolism
Feed additives
topic Orada
Polifenols
Metabolisme dels lípids
Additius de pinsos
Sparus aurata
Polyphenols
Lipid metabolism
Feed additives
description High-fat diets (HFDs) enhance fish growth by optimizing nutrient utilization (i.e., protein-sparing effect); however, their potential negative effects have also encouraged the search for feed additives. This work has investigated the effects of an extract rich in a polyphenolic antioxidant, hydroxytyrosol (HT), supplemented (0.52 g HT/kg feed) in a HFD (24% lipid) in gilthead sea bream (Sparus aurata). Fish received the diet at two ration levels, standard (3% of total fish weight) or restricted (40% reduction) for 8 weeks. Animals fed the supplemented diet at a standard ration had the lowest levels of plasma free fatty acids (4.28 ± 0.23 mg/dL versus 6.42 ± 0.47 in the non-supplemented group) and downregulated hepatic mRNA levels of lipid metabolism markers (ppara, pparb, lpl, fatp1, fabp1, acox1, lipe and lipa), supporting potential fat-lowering properties of this compound in the liver. Moreover, the same animals showed increased muscle lipid content and peroxidation (1.58- and 1.22-fold, respectively, compared to the fish without HT), suggesting the modulation of body adiposity distribution and an enhanced lipid oxidation rate in that tissue. Our findings emphasize the importance of considering this phytocompound as an optimal additive in HFDs for gilthead sea bream to improve overall fish health and condition.
publishDate 2024
dc.date.none.fl_str_mv 2024
2024
2024
2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/214628
url https://hdl.handle.net/2445/214628
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.3390/antiox13040403
Antioxidants, 2024, vol. 13, num.4, p. 1-21
https://doi.org/10.3390/antiox13040403
dc.rights.none.fl_str_mv cc-by (c) Balbuena-Pecino, S. et al., 2024
http://creativecommons.org/licenses/by/4.0/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by (c) Balbuena-Pecino, S. et al., 2024
http://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 21 p.
application/pdf
dc.publisher.none.fl_str_mv MDPI
publisher.none.fl_str_mv MDPI
dc.source.none.fl_str_mv Articles publicats en revistes (Biologia Cel·lular, Fisiologia i Immunologia)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
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score 15.81155

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