Potentiometric CheqSol and standardized shake-flask solubility methods are complimentary tools in physicochemical profiling

The solubility of three drugs (glimepiride, pioglitazone, sibutramine) with different acid/base properties and expected supersaturation behavior was examined in detail using the shake-flask (SF) and potentiometric (CheqSol) methods. Both uncharged (free) species and hydrochloride salts were used as...

ver descrição completa

Detalhes bibliográficos
Autores: Lucero Borja, Diego Sebastián, Subirats i Vila, Xavier, Barbas Cañero, Rafael, Prohens López, Rafael, Avdeef, Alex, Ràfols Llach, Clara
Tipo de documento: artigo
Estado:Versión aceptada para publicación
Data de publicação:2020
País:España
Recursos:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
Repositório:Recercat. Dipósit de la Recerca de Catalunya
OAI Identifier:oai:recercat.cat:2445/160859
Acesso em linha:https://hdl.handle.net/2445/160859
Access Level:Acceso aberto
Palavra-chave:Solubilitat
Sals
Solubility
Salts
id ES_7a34d71ff9d7761d1e0be73dcc91b307
oai_identifier_str oai:recercat.cat:2445/160859
network_acronym_str ES
network_name_str España
repository_id_str
spelling Potentiometric CheqSol and standardized shake-flask solubility methods are complimentary tools in physicochemical profilingLucero Borja, Diego SebastiánSubirats i Vila, XavierBarbas Cañero, RafaelProhens López, RafaelAvdeef, AlexRàfols Llach, ClaraSolubilitatSalsSolubilitySaltsThe solubility of three drugs (glimepiride, pioglitazone, sibutramine) with different acid/base properties and expected supersaturation behavior was examined in detail using the shake-flask (SF) and potentiometric (CheqSol) methods. Both uncharged (free) species and hydrochloride salts were used as starting materials. On the one hand, the SF method provided information about the thermodynamic solubility at any pH value, including the counterion-dependent solubility of ionic species. Additionally, this method easily allowed the identification of the solid phase in equilibrated solutions by powder X-ray diffraction, and the detection and quantification of aggregation and complexation reactions. On the other hand, CheqSol method permitted the measurement of the equilibrium solubility of neutral species, the observation of changes in solid forms, and the extent and duration of supersaturation (kinetic solubility) for 'chaser' compounds. The combined information from both methods gave an accurate picture of the solubility behavior of the studied drugs.Elsevier B.V.2020202120202020info:eu-repo/semantics/articleinfo:eu-repo/semantics/acceptedVersion39 p.application/pdfhttps://hdl.handle.net/2445/160859Articles publicats en revistes (Enginyeria Química i Química Analítica)reponame:Recercat. Dipósit de la Recerca de Catalunyainstname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)InglésVersió postprint del document publicat a: https://doi.org/10.1016/j.ejps.2020.105305European Journal of Pharmaceutical Sciences, 2020, vol. 148, p. 105305https://doi.org/10.1016/j.ejps.2020.105305cc-by-nc-nd (c) Elsevier B.V., 2020http://creativecommons.org/licenses/by-nc-nd/3.0/esinfo:eu-repo/semantics/openAccessoai:recercat.cat:2445/1608592026-05-29T05:05:01Z
dc.title.none.fl_str_mv Potentiometric CheqSol and standardized shake-flask solubility methods are complimentary tools in physicochemical profiling
title Potentiometric CheqSol and standardized shake-flask solubility methods are complimentary tools in physicochemical profiling
spellingShingle Potentiometric CheqSol and standardized shake-flask solubility methods are complimentary tools in physicochemical profiling
Lucero Borja, Diego Sebastián
Solubilitat
Sals
Solubility
Salts
title_short Potentiometric CheqSol and standardized shake-flask solubility methods are complimentary tools in physicochemical profiling
title_full Potentiometric CheqSol and standardized shake-flask solubility methods are complimentary tools in physicochemical profiling
title_fullStr Potentiometric CheqSol and standardized shake-flask solubility methods are complimentary tools in physicochemical profiling
title_full_unstemmed Potentiometric CheqSol and standardized shake-flask solubility methods are complimentary tools in physicochemical profiling
title_sort Potentiometric CheqSol and standardized shake-flask solubility methods are complimentary tools in physicochemical profiling
dc.creator.none.fl_str_mv Lucero Borja, Diego Sebastián
Subirats i Vila, Xavier
Barbas Cañero, Rafael
Prohens López, Rafael
Avdeef, Alex
Ràfols Llach, Clara
author Lucero Borja, Diego Sebastián
author_facet Lucero Borja, Diego Sebastián
Subirats i Vila, Xavier
Barbas Cañero, Rafael
Prohens López, Rafael
Avdeef, Alex
Ràfols Llach, Clara
author_role author
author2 Subirats i Vila, Xavier
Barbas Cañero, Rafael
Prohens López, Rafael
Avdeef, Alex
Ràfols Llach, Clara
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Solubilitat
Sals
Solubility
Salts
topic Solubilitat
Sals
Solubility
Salts
description The solubility of three drugs (glimepiride, pioglitazone, sibutramine) with different acid/base properties and expected supersaturation behavior was examined in detail using the shake-flask (SF) and potentiometric (CheqSol) methods. Both uncharged (free) species and hydrochloride salts were used as starting materials. On the one hand, the SF method provided information about the thermodynamic solubility at any pH value, including the counterion-dependent solubility of ionic species. Additionally, this method easily allowed the identification of the solid phase in equilibrated solutions by powder X-ray diffraction, and the detection and quantification of aggregation and complexation reactions. On the other hand, CheqSol method permitted the measurement of the equilibrium solubility of neutral species, the observation of changes in solid forms, and the extent and duration of supersaturation (kinetic solubility) for 'chaser' compounds. The combined information from both methods gave an accurate picture of the solubility behavior of the studied drugs.
publishDate 2020
dc.date.none.fl_str_mv 2020
2020
2020
2021
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/acceptedVersion
format article
status_str acceptedVersion
dc.identifier.none.fl_str_mv https://hdl.handle.net/2445/160859
url https://hdl.handle.net/2445/160859
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Versió postprint del document publicat a: https://doi.org/10.1016/j.ejps.2020.105305
European Journal of Pharmaceutical Sciences, 2020, vol. 148, p. 105305
https://doi.org/10.1016/j.ejps.2020.105305
dc.rights.none.fl_str_mv cc-by-nc-nd (c) Elsevier B.V., 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es
info:eu-repo/semantics/openAccess
rights_invalid_str_mv cc-by-nc-nd (c) Elsevier B.V., 2020
http://creativecommons.org/licenses/by-nc-nd/3.0/es
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 39 p.
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv Articles publicats en revistes (Enginyeria Química i Química Analítica)
reponame:Recercat. Dipósit de la Recerca de Catalunya
instname:Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
instname_str Varias* (Consorci de Biblioteques Universitáries de Catalunya, Centre de Serveis Científics i Acadèmics de Catalunya)
reponame_str Recercat. Dipósit de la Recerca de Catalunya
collection Recercat. Dipósit de la Recerca de Catalunya
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411420996632576
score 15,811543

Registros relacionados