Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy

To investigate the frequency, time-course and predictors of intracerebral haemorrhage (ICH), recurrent convexity subarachnoid haemorrhage (cSAH), and ischemic stroke after cSAH associated with cerebral amyloid angiopathy (CAA). We performed a systematic review and international individual patient-da...

Descripción completa

Detalles Bibliográficos
Autores: Hostettler, Isabel Charlotte|||0000-0002-9004-2540, Wilson, Duncan, Fiebelkorn, Catherine Arnold, Aum, Diane, Ameriso, Sebastián Francisco, Eberbach, Federico, Beitzke, Markus, Kleinig, Timothy|||0000-0003-4430-3276, Phan, Thanh|||0000-0003-3400-6323, Marchina, Sarah, Schneckenburger, Romain, Carmona Iragui, Maria|||0000-0001-6914-2339, Charidimou, Andreas, Mourand, Isabelle, Parreira, Sara, Ambler, Gareth, Jäger, Hans Rolf|||0000-0002-6403-4184, Singhal, Shaloo, Ly, John, Ma, Henry|||0000-0002-0510-8059, Touzé, Emmanuel, Geraldes, Ruth|||0000-0001-5829-808X, Fonseca, Ana Catarina|||0000-0001-6913-5526, Melo, Teresa, Labauge, Pierre, Lefèvre, Pierre-Henry, Viswanathan, Anand, Greenberg, Steven Mark, Fortea, Juan|||0000-0002-1340-638X, Apoil, Marion, Boulanger, Marion, Viader, Fausto, Kumar, Sandeep, Srikanth, Velandai, Khurram, Ashan, Fazekas, Franz|||0000-0001-8155-7799, Bruno, Veronica, Zipfel, Gregory Joseph, Refai, Daniel, Rabinstein, Alejandro, Graff-Radford, Jonathan, Werring, David John
Tipo de recurso: artículo
Fecha de publicación:2021
País:España
Institución:Universitat Autònoma de Barcelona
Repositorio:Dipòsit Digital de Documents de la UAB
Idioma:inglés
OAI Identifier:oai:ddd.uab.cat:256510
Acceso en línea:https://ddd.uab.cat/record/256510
https://dx.doi.org/urn:doi:10.1007/s00415-021-10706-3
Access Level:acceso abierto
Palabra clave:Non-traumatic convexity/convexal/cortical subarachnoid haemorrhage
Intracerebral haemorrhage
Ischemic stroke
Cerebral amyloid angiopathy
Stroke
id ES_7a309e716c8f03bb6a5fd5cf1d0fe9b5
oai_identifier_str oai:ddd.uab.cat:256510
network_acronym_str ES
network_name_str España
repository_id_str
spelling Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathyinternational individual patient data pooled analysisHostettler, Isabel Charlotte|||0000-0002-9004-2540Wilson, DuncanFiebelkorn, Catherine ArnoldAum, DianeAmeriso, Sebastián FranciscoEberbach, FedericoBeitzke, MarkusKleinig, Timothy|||0000-0003-4430-3276Phan, Thanh|||0000-0003-3400-6323Marchina, SarahSchneckenburger, RomainCarmona Iragui, Maria|||0000-0001-6914-2339Charidimou, AndreasMourand, IsabelleParreira, SaraAmbler, GarethJäger, Hans Rolf|||0000-0002-6403-4184Singhal, ShalooLy, JohnMa, Henry|||0000-0002-0510-8059Touzé, EmmanuelGeraldes, Ruth|||0000-0001-5829-808XFonseca, Ana Catarina|||0000-0001-6913-5526Melo, TeresaLabauge, PierreLefèvre, Pierre-HenryViswanathan, AnandGreenberg, Steven MarkFortea, Juan|||0000-0002-1340-638XApoil, MarionBoulanger, MarionViader, FaustoKumar, SandeepSrikanth, VelandaiKhurram, AshanFazekas, Franz|||0000-0001-8155-7799Bruno, VeronicaZipfel, Gregory JosephRefai, DanielRabinstein, AlejandroGraff-Radford, JonathanWerring, David JohnNon-traumatic convexity/convexal/cortical subarachnoid haemorrhageIntracerebral haemorrhageIschemic strokeCerebral amyloid angiopathyStrokeTo investigate the frequency, time-course and predictors of intracerebral haemorrhage (ICH), recurrent convexity subarachnoid haemorrhage (cSAH), and ischemic stroke after cSAH associated with cerebral amyloid angiopathy (CAA). We performed a systematic review and international individual patient-data pooled analysis in patients with cSAH associated with probable or possible CAA diagnosed on baseline MRI using the modified Boston criteria. We used Cox proportional hazards models with a frailty term to account for between-cohort differences. We included 190 patients (mean age 74.5 years; 45.3% female) from 13 centers with 385 patient-years of follow-up (median 1.4 years). The risks of each outcome (per patient-year) were: ICH 13.2% (95% CI 9.9-17.4); recurrent cSAH 11.1% (95% CI 7.9-15.2); combined ICH, cSAH, or both 21.4% (95% CI 16.7-26.9), ischemic stroke 5.1% (95% CI 3.1-8) and death 8.3% (95% CI 5.6-11.8). In multivariable models, there is evidence that patients with probable CAA (compared to possible CAA) had a higher risk of ICH (HR 8.45, 95% CI 1.13-75.5, p = 0.02) and cSAH (HR 3.66, 95% CI 0.84-15.9, p = 0.08) but not ischemic stroke (HR 0.56, 95% CI 0.17-1.82, p = 0.33) or mortality (HR 0.54, 95% CI 0.16-1.78, p = 0.31). Patients with cSAH associated with probable or possible CAA have high risk of future ICH and recurrent cSAH. Convexity SAH associated with probable (vs possible) CAA is associated with increased risk of ICH, and cSAH but not ischemic stroke. Our data provide precise risk estimates for key vascular events after cSAH associated with CAA which can inform management decisions. The online version contains supplementary material available at 10.1007/s00415-021-10706-3.Universitat Autònoma de Barcelona 22021-01-0120212021-01-01Article de revisióhttp://purl.org/coar/resource_type/c_dcae04bcVoRhttp://purl.org/coar/version/c_970fb48d4fbd8a85info:eu-repo/semantics/articleapplication/pdfhttps://ddd.uab.cat/record/256510https://dx.doi.org/urn:doi:10.1007/s00415-021-10706-3reponame:Dipòsit Digital de Documents de la UABinstname:Universitat Autònoma de BarcelonaInglésengopen accesshttp://purl.org/coar/access_right/c_abf2Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.https://creativecommons.org/licenses/by/4.0/info:eu-repo/semantics/openAccessoai:ddd.uab.cat:2565102026-06-06T12:50:31Z
dc.title.none.fl_str_mv Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy
international individual patient data pooled analysis
title Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy
spellingShingle Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy
Hostettler, Isabel Charlotte|||0000-0002-9004-2540
Non-traumatic convexity/convexal/cortical subarachnoid haemorrhage
Intracerebral haemorrhage
Ischemic stroke
Cerebral amyloid angiopathy
Stroke
title_short Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy
title_full Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy
title_fullStr Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy
title_full_unstemmed Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy
title_sort Risk of intracranial haemorrhage and ischaemic stroke after convexity subarachnoid haemorrhage in cerebral amyloid angiopathy
dc.creator.none.fl_str_mv Hostettler, Isabel Charlotte|||0000-0002-9004-2540
Wilson, Duncan
Fiebelkorn, Catherine Arnold
Aum, Diane
Ameriso, Sebastián Francisco
Eberbach, Federico
Beitzke, Markus
Kleinig, Timothy|||0000-0003-4430-3276
Phan, Thanh|||0000-0003-3400-6323
Marchina, Sarah
Schneckenburger, Romain
Carmona Iragui, Maria|||0000-0001-6914-2339
Charidimou, Andreas
Mourand, Isabelle
Parreira, Sara
Ambler, Gareth
Jäger, Hans Rolf|||0000-0002-6403-4184
Singhal, Shaloo
Ly, John
Ma, Henry|||0000-0002-0510-8059
Touzé, Emmanuel
Geraldes, Ruth|||0000-0001-5829-808X
Fonseca, Ana Catarina|||0000-0001-6913-5526
Melo, Teresa
Labauge, Pierre
Lefèvre, Pierre-Henry
Viswanathan, Anand
Greenberg, Steven Mark
Fortea, Juan|||0000-0002-1340-638X
Apoil, Marion
Boulanger, Marion
Viader, Fausto
Kumar, Sandeep
Srikanth, Velandai
Khurram, Ashan
Fazekas, Franz|||0000-0001-8155-7799
Bruno, Veronica
Zipfel, Gregory Joseph
Refai, Daniel
Rabinstein, Alejandro
Graff-Radford, Jonathan
Werring, David John
author Hostettler, Isabel Charlotte|||0000-0002-9004-2540
author_facet Hostettler, Isabel Charlotte|||0000-0002-9004-2540
Wilson, Duncan
Fiebelkorn, Catherine Arnold
Aum, Diane
Ameriso, Sebastián Francisco
Eberbach, Federico
Beitzke, Markus
Kleinig, Timothy|||0000-0003-4430-3276
Phan, Thanh|||0000-0003-3400-6323
Marchina, Sarah
Schneckenburger, Romain
Carmona Iragui, Maria|||0000-0001-6914-2339
Charidimou, Andreas
Mourand, Isabelle
Parreira, Sara
Ambler, Gareth
Jäger, Hans Rolf|||0000-0002-6403-4184
Singhal, Shaloo
Ly, John
Ma, Henry|||0000-0002-0510-8059
Touzé, Emmanuel
Geraldes, Ruth|||0000-0001-5829-808X
Fonseca, Ana Catarina|||0000-0001-6913-5526
Melo, Teresa
Labauge, Pierre
Lefèvre, Pierre-Henry
Viswanathan, Anand
Greenberg, Steven Mark
Fortea, Juan|||0000-0002-1340-638X
Apoil, Marion
Boulanger, Marion
Viader, Fausto
Kumar, Sandeep
Srikanth, Velandai
Khurram, Ashan
Fazekas, Franz|||0000-0001-8155-7799
Bruno, Veronica
Zipfel, Gregory Joseph
Refai, Daniel
Rabinstein, Alejandro
Graff-Radford, Jonathan
Werring, David John
author_role author
author2 Wilson, Duncan
Fiebelkorn, Catherine Arnold
Aum, Diane
Ameriso, Sebastián Francisco
Eberbach, Federico
Beitzke, Markus
Kleinig, Timothy|||0000-0003-4430-3276
Phan, Thanh|||0000-0003-3400-6323
Marchina, Sarah
Schneckenburger, Romain
Carmona Iragui, Maria|||0000-0001-6914-2339
Charidimou, Andreas
Mourand, Isabelle
Parreira, Sara
Ambler, Gareth
Jäger, Hans Rolf|||0000-0002-6403-4184
Singhal, Shaloo
Ly, John
Ma, Henry|||0000-0002-0510-8059
Touzé, Emmanuel
Geraldes, Ruth|||0000-0001-5829-808X
Fonseca, Ana Catarina|||0000-0001-6913-5526
Melo, Teresa
Labauge, Pierre
Lefèvre, Pierre-Henry
Viswanathan, Anand
Greenberg, Steven Mark
Fortea, Juan|||0000-0002-1340-638X
Apoil, Marion
Boulanger, Marion
Viader, Fausto
Kumar, Sandeep
Srikanth, Velandai
Khurram, Ashan
Fazekas, Franz|||0000-0001-8155-7799
Bruno, Veronica
Zipfel, Gregory Joseph
Refai, Daniel
Rabinstein, Alejandro
Graff-Radford, Jonathan
Werring, David John
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universitat Autònoma de Barcelona
dc.subject.none.fl_str_mv Non-traumatic convexity/convexal/cortical subarachnoid haemorrhage
Intracerebral haemorrhage
Ischemic stroke
Cerebral amyloid angiopathy
Stroke
topic Non-traumatic convexity/convexal/cortical subarachnoid haemorrhage
Intracerebral haemorrhage
Ischemic stroke
Cerebral amyloid angiopathy
Stroke
description To investigate the frequency, time-course and predictors of intracerebral haemorrhage (ICH), recurrent convexity subarachnoid haemorrhage (cSAH), and ischemic stroke after cSAH associated with cerebral amyloid angiopathy (CAA). We performed a systematic review and international individual patient-data pooled analysis in patients with cSAH associated with probable or possible CAA diagnosed on baseline MRI using the modified Boston criteria. We used Cox proportional hazards models with a frailty term to account for between-cohort differences. We included 190 patients (mean age 74.5 years; 45.3% female) from 13 centers with 385 patient-years of follow-up (median 1.4 years). The risks of each outcome (per patient-year) were: ICH 13.2% (95% CI 9.9-17.4); recurrent cSAH 11.1% (95% CI 7.9-15.2); combined ICH, cSAH, or both 21.4% (95% CI 16.7-26.9), ischemic stroke 5.1% (95% CI 3.1-8) and death 8.3% (95% CI 5.6-11.8). In multivariable models, there is evidence that patients with probable CAA (compared to possible CAA) had a higher risk of ICH (HR 8.45, 95% CI 1.13-75.5, p = 0.02) and cSAH (HR 3.66, 95% CI 0.84-15.9, p = 0.08) but not ischemic stroke (HR 0.56, 95% CI 0.17-1.82, p = 0.33) or mortality (HR 0.54, 95% CI 0.16-1.78, p = 0.31). Patients with cSAH associated with probable or possible CAA have high risk of future ICH and recurrent cSAH. Convexity SAH associated with probable (vs possible) CAA is associated with increased risk of ICH, and cSAH but not ischemic stroke. Our data provide precise risk estimates for key vascular events after cSAH associated with CAA which can inform management decisions. The online version contains supplementary material available at 10.1007/s00415-021-10706-3.
publishDate 2021
dc.date.none.fl_str_mv 2
2021-01-01
2021
2021-01-01
dc.type.none.fl_str_mv Article de revisió
http://purl.org/coar/resource_type/c_dcae04bc
VoR
http://purl.org/coar/version/c_970fb48d4fbd8a85
dc.type.openaire.fl_str_mv info:eu-repo/semantics/article
format article
dc.identifier.none.fl_str_mv https://ddd.uab.cat/record/256510
https://dx.doi.org/urn:doi:10.1007/s00415-021-10706-3
url https://ddd.uab.cat/record/256510
https://dx.doi.org/urn:doi:10.1007/s00415-021-10706-3
dc.language.none.fl_str_mv Inglés
eng
language_invalid_str_mv Inglés
language eng
dc.rights.none.fl_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
dc.rights.openaire.fl_str_mv info:eu-repo/semantics/openAccess
rights_invalid_str_mv open access
http://purl.org/coar/access_right/c_abf2
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.source.none.fl_str_mv reponame:Dipòsit Digital de Documents de la UAB
instname:Universitat Autònoma de Barcelona
instname_str Universitat Autònoma de Barcelona
reponame_str Dipòsit Digital de Documents de la UAB
collection Dipòsit Digital de Documents de la UAB
repository.name.fl_str_mv
repository.mail.fl_str_mv
_version_ 1869411419522334720
score 15,811543

Similares en LA Referencia