Placental MFSD2A expression in fetal growth restriction and maternal and fetal DHA status

Introduction: Fetal growth restriction (FGR) may affect placental transfer of key nutrients to the fetus, such as the fatty acid docosahexaenoic acid (DHA). Major facilitator superfamily domain containing 2A (MFSD2A) has been described as a specific DHA carrier in placenta, but its expression has no...

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Autores: Origüela V, Ferrer-Aguilar P, Gázquez A, Pérez-Cruz M, Gómez-Roig MD, Gómez-Llorente C, Larqué E
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2024
País:España
Institución:Fundació Sant Joan de Déu
Repositorio:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
OAI Identifier:oai:fsjd.fundanetsuite.com:p26150
Acceso en línea:https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=26150
Access Level:acceso abierto
Palabra clave:Docosahexaenoic acid
Fatty acid
Fetal growth restriction
Small fetus
Placental insufficiency
Placental transfer
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spelling Placental MFSD2A expression in fetal growth restriction and maternal and fetal DHA statusOrigüela VFerrer-Aguilar PGázquez APérez-Cruz MGómez-Roig MDGómez-Llorente CLarqué EDocosahexaenoic acidFatty acidFetal growth restrictionSmall fetusPlacental insufficiencyPlacental transferIntroduction: Fetal growth restriction (FGR) may affect placental transfer of key nutrients to the fetus, such as the fatty acid docosahexaenoic acid (DHA). Major facilitator superfamily domain containing 2A (MFSD2A) has been described as a specific DHA carrier in placenta, but its expression has not been studied in FGR. The aim of this study was to evaluate for the first time the placental MFSD2A levels in late-FGR pregnancies and the maternal and cord plasma DHA. Methods: 87 pregnant women from a tertial reference center were classified into late-FGR (N = 18) or control (N = 69). Fatty acid profile was determined in maternal and cord venous plasma, as well as placental levels of MFSD2A and of insulin mediators like phospho-protein kinase B (phospho-AKT) and phospho-extracellular regulated kinase (phospho-ERK). Results: Maternal fatty acid profile did not differ between groups. Nevertheless, late-FGR cord vein presented higher content of saturated fatty acids than control, producing a concomitant decrease in the percentage of some unsaturated fatty acids. In the late-FGR group, a lower DHA fetal/maternal ratio was observed when using percentages, but not with concentrations. No alterations were found in the expression of MFSD2A in late-FGR placentas, nor in phospho-AKT or phospho-ERK. Discussion: MFSD2A protein expression was not altered in late-FGR placentas, in line with no differences in cord DHA concentration between groups. The increase in the saturated fatty acid content of late-FGR cord might be a compensatory mechanism to ensure fetal energy supply, decreasing other fatty acids percentage. Future studies are warranted to elucidate if altered saturated fatty acid profile in late-FGR fetuses might predispose them to postnatal catch-up and to long-term health consequences.W B SAUNDERS CO LTD2024info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttps://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=26150PLACENTAISSN: 01434004ISSNe: 15323102reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déuinstname:Fundació Sant Joan de DéuInglésinfo:eu-repo/semantics/openAccessoai:fsjd.fundanetsuite.com:p261502026-05-27T12:37:41Z
dc.title.none.fl_str_mv Placental MFSD2A expression in fetal growth restriction and maternal and fetal DHA status
title Placental MFSD2A expression in fetal growth restriction and maternal and fetal DHA status
spellingShingle Placental MFSD2A expression in fetal growth restriction and maternal and fetal DHA status
Origüela V
Docosahexaenoic acid
Fatty acid
Fetal growth restriction
Small fetus
Placental insufficiency
Placental transfer
title_short Placental MFSD2A expression in fetal growth restriction and maternal and fetal DHA status
title_full Placental MFSD2A expression in fetal growth restriction and maternal and fetal DHA status
title_fullStr Placental MFSD2A expression in fetal growth restriction and maternal and fetal DHA status
title_full_unstemmed Placental MFSD2A expression in fetal growth restriction and maternal and fetal DHA status
title_sort Placental MFSD2A expression in fetal growth restriction and maternal and fetal DHA status
dc.creator.none.fl_str_mv Origüela V
Ferrer-Aguilar P
Gázquez A
Pérez-Cruz M
Gómez-Roig MD
Gómez-Llorente C
Larqué E
author Origüela V
author_facet Origüela V
Ferrer-Aguilar P
Gázquez A
Pérez-Cruz M
Gómez-Roig MD
Gómez-Llorente C
Larqué E
author_role author
author2 Ferrer-Aguilar P
Gázquez A
Pérez-Cruz M
Gómez-Roig MD
Gómez-Llorente C
Larqué E
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Docosahexaenoic acid
Fatty acid
Fetal growth restriction
Small fetus
Placental insufficiency
Placental transfer
topic Docosahexaenoic acid
Fatty acid
Fetal growth restriction
Small fetus
Placental insufficiency
Placental transfer
description Introduction: Fetal growth restriction (FGR) may affect placental transfer of key nutrients to the fetus, such as the fatty acid docosahexaenoic acid (DHA). Major facilitator superfamily domain containing 2A (MFSD2A) has been described as a specific DHA carrier in placenta, but its expression has not been studied in FGR. The aim of this study was to evaluate for the first time the placental MFSD2A levels in late-FGR pregnancies and the maternal and cord plasma DHA. Methods: 87 pregnant women from a tertial reference center were classified into late-FGR (N = 18) or control (N = 69). Fatty acid profile was determined in maternal and cord venous plasma, as well as placental levels of MFSD2A and of insulin mediators like phospho-protein kinase B (phospho-AKT) and phospho-extracellular regulated kinase (phospho-ERK). Results: Maternal fatty acid profile did not differ between groups. Nevertheless, late-FGR cord vein presented higher content of saturated fatty acids than control, producing a concomitant decrease in the percentage of some unsaturated fatty acids. In the late-FGR group, a lower DHA fetal/maternal ratio was observed when using percentages, but not with concentrations. No alterations were found in the expression of MFSD2A in late-FGR placentas, nor in phospho-AKT or phospho-ERK. Discussion: MFSD2A protein expression was not altered in late-FGR placentas, in line with no differences in cord DHA concentration between groups. The increase in the saturated fatty acid content of late-FGR cord might be a compensatory mechanism to ensure fetal energy supply, decreasing other fatty acids percentage. Future studies are warranted to elucidate if altered saturated fatty acid profile in late-FGR fetuses might predispose them to postnatal catch-up and to long-term health consequences.
publishDate 2024
dc.date.none.fl_str_mv 2024
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=26150
url https://fsjd.fundanetsuite.com/Publicaciones/ProdCientif/PublicacionFrw.aspx?id=26150
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv W B SAUNDERS CO LTD
publisher.none.fl_str_mv W B SAUNDERS CO LTD
dc.source.none.fl_str_mv PLACENTA
ISSN: 01434004
ISSNe: 15323102
reponame:r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
instname:Fundació Sant Joan de Déu
instname_str Fundació Sant Joan de Déu
reponame_str r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
collection r-FSJD. Repositorio Institucional de Producción Científica de la Fundació Sant Joan de Déu
repository.name.fl_str_mv
repository.mail.fl_str_mv
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