Survival of viral pathogens in animal feed ingredients under transboundary shipping models

The goal of this study was to evaluate survival of important viral pathogens of livestock in animal feed ingredients imported daily into the United States under simulated transboundary conditions. Eleven viruses were selected based on global significance and impact to the livestock industry, includi...

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Autores: Dee, Scott, Bauermann, Fernando, Niederwerder, Megan, Singrey, Aaron, Clement, Travis, de Lima, Marcelo, Long, Craig, Patterson, Gilbert, Sheahan, Maureen, Stoian, Ana Maria Mihaela, Petrovan, Vlad, Jones, Cassandra, De Jong, Jon, Ji, Ju, Spronk, Gordon
Tipo de recurso: artículo
Estado:Versión publicada
Fecha de publicación:2018
País:España
Institución:Universitat de Lleida (UdL)
Repositorio:Repositori Obert UdL
OAI Identifier:oai:repositori.udl.cat:10459.1/465999
Acceso en línea:https://doi.org/10.1371/journal.pone.0194509
https://hdl.handle.net/10459.1/465999
Access Level:acceso abierto
Palabra clave:Viral pathogens
Vesicular stomatitis virus
Swine
Livestock
Foot and mouth disease
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spelling Survival of viral pathogens in animal feed ingredients under transboundary shipping modelsDee, Scott Bauermann, Fernando Niederwerder, Megan Singrey, AaronClement, Travis de Lima, Marcelo Long, Craig Patterson, GilbertSheahan, Maureen Stoian, Ana Maria Mihaela Petrovan, Vlad Jones, Cassandra De Jong, Jon Ji, Ju Spronk, GordonViral pathogensVesicular stomatitis virusSwineLivestockFoot and mouth diseaseThe goal of this study was to evaluate survival of important viral pathogens of livestock in animal feed ingredients imported daily into the United States under simulated transboundary conditions. Eleven viruses were selected based on global significance and impact to the livestock industry, including Foot and Mouth Disease Virus (FMDV), Classical Swine Fever Virus (CSFV), African Swine Fever Virus (ASFV), Influenza A Virus of Swine (IAV-S), Pseudorabies virus (PRV), Nipah Virus (NiV), Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), Swine Vesicular Disease Virus (SVDV), Vesicular Stomatitis Virus (VSV), Porcine Circovirus Type 2 (PCV2) and Vesicular Exanthema of Swine Virus (VESV). Surrogate viruses with similar genetic and physical properties were used for 6 viruses. Surrogates belonged to the same virus families as target pathogens, and included Senecavirus A (SVA) for FMDV, Bovine Viral Diarrhea Virus (BVDV) for CSFV, Bovine Herpesvirus Type 1 (BHV1) for PRV, Canine Distemper Virus (CDV) for NiV, Porcine Sapelovirus (PSV) for SVDV and Feline Calicivirus (FCV) for VESV. For the remaining target viruses, actual pathogens were used. Virus survival was evaluated using Trans-Pacific or Trans-Atlantic transboundary models involving representative feed ingredients, transport times and environmental conditions, with samples tested by PCR, VI and/or swine bioassay. SVA (representing FMDV), FCV (representing VESV), BHV-1 (representing PRV), PRRSV, PSV (representing SVDV), ASFV and PCV2 maintained infectivity during transport, while BVDV (representing CSFV), VSV, CDV (representing NiV) and IAV-S did not. Notably, more viruses survived in conventional soybean meal, lysine hydrochloride, choline chloride, vitamin D and pork sausage casings. These results support published data on transboundary risk of PEDV in feed, demonstrate survival of certain viruses in specific feed ingredients (“high-risk combinations”) under conditions simulating transport between continents and provide further evidence that contaminated feed ingredients may represent a risk for transport of pathogens at domestic and global levels. This work was supported by the Swine Health InformationCenter, grants numbers 16-154 and 17-142.American Association of Swine VeterinariansFoundation(no grant number). State of Kansas National Bio and Agro-Defense Facility Fund (no grant number). SDSU Animal Disease Research and Diagnostic Laboratory (no grant number). The businessunit of PipestoneApplied Research (PipestoneHoldings) providedsalaries for individuals (SD, GDM, JD and LM) to assist with study design, data collection and analysis, decision to publish, or preparation of the manuscript. The specific roles of these authors are articulatedin the ‘authorcontributions’section.Public Library of Science2018info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionapplication/pdfhttps://doi.org/10.1371/journal.pone.0194509https://hdl.handle.net/10459.1/465999reponame:Repositori Obert UdL instname:Universitat de Lleida (UdL)InglésReproducció del document publicat a: https://doi.org/10.1371/journal.pone.0194509Plos One, 2018cc-by, (c) Dee et al., 2018info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/4.0/oai:repositori.udl.cat:10459.1/4659992026-06-24T12:42:17Z
dc.title.none.fl_str_mv Survival of viral pathogens in animal feed ingredients under transboundary shipping models
title Survival of viral pathogens in animal feed ingredients under transboundary shipping models
spellingShingle Survival of viral pathogens in animal feed ingredients under transboundary shipping models
Dee, Scott
Viral pathogens
Vesicular stomatitis virus
Swine
Livestock
Foot and mouth disease
title_short Survival of viral pathogens in animal feed ingredients under transboundary shipping models
title_full Survival of viral pathogens in animal feed ingredients under transboundary shipping models
title_fullStr Survival of viral pathogens in animal feed ingredients under transboundary shipping models
title_full_unstemmed Survival of viral pathogens in animal feed ingredients under transboundary shipping models
title_sort Survival of viral pathogens in animal feed ingredients under transboundary shipping models
dc.creator.none.fl_str_mv Dee, Scott
Bauermann, Fernando
Niederwerder, Megan
Singrey, Aaron
Clement, Travis
de Lima, Marcelo
Long, Craig
Patterson, Gilbert
Sheahan, Maureen
Stoian, Ana Maria Mihaela
Petrovan, Vlad
Jones, Cassandra
De Jong, Jon
Ji, Ju
Spronk, Gordon
author Dee, Scott
author_facet Dee, Scott
Bauermann, Fernando
Niederwerder, Megan
Singrey, Aaron
Clement, Travis
de Lima, Marcelo
Long, Craig
Patterson, Gilbert
Sheahan, Maureen
Stoian, Ana Maria Mihaela
Petrovan, Vlad
Jones, Cassandra
De Jong, Jon
Ji, Ju
Spronk, Gordon
author_role author
author2 Bauermann, Fernando
Niederwerder, Megan
Singrey, Aaron
Clement, Travis
de Lima, Marcelo
Long, Craig
Patterson, Gilbert
Sheahan, Maureen
Stoian, Ana Maria Mihaela
Petrovan, Vlad
Jones, Cassandra
De Jong, Jon
Ji, Ju
Spronk, Gordon
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Viral pathogens
Vesicular stomatitis virus
Swine
Livestock
Foot and mouth disease
topic Viral pathogens
Vesicular stomatitis virus
Swine
Livestock
Foot and mouth disease
description The goal of this study was to evaluate survival of important viral pathogens of livestock in animal feed ingredients imported daily into the United States under simulated transboundary conditions. Eleven viruses were selected based on global significance and impact to the livestock industry, including Foot and Mouth Disease Virus (FMDV), Classical Swine Fever Virus (CSFV), African Swine Fever Virus (ASFV), Influenza A Virus of Swine (IAV-S), Pseudorabies virus (PRV), Nipah Virus (NiV), Porcine Reproductive and Respiratory Syndrome Virus (PRRSV), Swine Vesicular Disease Virus (SVDV), Vesicular Stomatitis Virus (VSV), Porcine Circovirus Type 2 (PCV2) and Vesicular Exanthema of Swine Virus (VESV). Surrogate viruses with similar genetic and physical properties were used for 6 viruses. Surrogates belonged to the same virus families as target pathogens, and included Senecavirus A (SVA) for FMDV, Bovine Viral Diarrhea Virus (BVDV) for CSFV, Bovine Herpesvirus Type 1 (BHV1) for PRV, Canine Distemper Virus (CDV) for NiV, Porcine Sapelovirus (PSV) for SVDV and Feline Calicivirus (FCV) for VESV. For the remaining target viruses, actual pathogens were used. Virus survival was evaluated using Trans-Pacific or Trans-Atlantic transboundary models involving representative feed ingredients, transport times and environmental conditions, with samples tested by PCR, VI and/or swine bioassay. SVA (representing FMDV), FCV (representing VESV), BHV-1 (representing PRV), PRRSV, PSV (representing SVDV), ASFV and PCV2 maintained infectivity during transport, while BVDV (representing CSFV), VSV, CDV (representing NiV) and IAV-S did not. Notably, more viruses survived in conventional soybean meal, lysine hydrochloride, choline chloride, vitamin D and pork sausage casings. These results support published data on transboundary risk of PEDV in feed, demonstrate survival of certain viruses in specific feed ingredients (“high-risk combinations”) under conditions simulating transport between continents and provide further evidence that contaminated feed ingredients may represent a risk for transport of pathogens at domestic and global levels.
publishDate 2018
dc.date.none.fl_str_mv 2018
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv https://doi.org/10.1371/journal.pone.0194509
https://hdl.handle.net/10459.1/465999
url https://doi.org/10.1371/journal.pone.0194509
https://hdl.handle.net/10459.1/465999
dc.language.none.fl_str_mv Inglés
language_invalid_str_mv Inglés
dc.relation.none.fl_str_mv Reproducció del document publicat a: https://doi.org/10.1371/journal.pone.0194509
Plos One, 2018
dc.rights.none.fl_str_mv cc-by, (c) Dee et al., 2018
info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/4.0/
rights_invalid_str_mv cc-by, (c) Dee et al., 2018
https://creativecommons.org/licenses/by/4.0/
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv application/pdf
dc.publisher.none.fl_str_mv Public Library of Science
publisher.none.fl_str_mv Public Library of Science
dc.source.none.fl_str_mv reponame:Repositori Obert UdL
instname:Universitat de Lleida (UdL)
instname_str Universitat de Lleida (UdL)
reponame_str Repositori Obert UdL
collection Repositori Obert UdL
repository.name.fl_str_mv
repository.mail.fl_str_mv
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