Cerium doped dendritic mesoporous bioactive glass nanoparticles with bioactivity and drug delivery capability
Dendritic mesoporous bioactive glass nanoparticles (DMBGNs) with unique three-dimensional structures are attracting increasing attention for biomedical applications. However, it is still challenging to tune the chemical composition of DMBGNs. In this work, we provide for the first time a feasible po...
| Autores: | , , , , |
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| Tipo de documento: | artigo |
| Estado: | Versión enviada para evaluación y publicación |
| Data de publicação: | 2023 |
| País: | España |
| Recursos: | Universidad de Sevilla (US) |
| Repositório: | idUS. Depósito de Investigación de la Universidad de Sevilla |
| OAI Identifier: | oai:idus.us.es:11441/148631 |
| Acesso em linha: | https://hdl.handle.net/11441/148631 https://doi.org/10.1016/j.jnoncrysol.2023.122578 |
| Access Level: | Acceso aberto |
| Palavra-chave: | Cerium Bioactive glass Dendritic mesoporous nanoparticle Bioactivity Drug delivery |
| Resumo: | Dendritic mesoporous bioactive glass nanoparticles (DMBGNs) with unique three-dimensional structures are attracting increasing attention for biomedical applications. However, it is still challenging to tune the chemical composition of DMBGNs. In this work, we provide for the first time a feasible post-impregnation approach to incorporate metallic ions (Ca and Ce) into dendritic mesoporous silica nanoparticles, resulting in SiO₂-CaO and SiO₂-CaO-CeO₂ (Ce-DMBGNs) without destroying the dendritic mesoporous topography. Both DMBGNs and Ce-DMBGNs were amorphous, negatively charged, with a hydrodynamic size of ∼200 nm. The synthesized DMBGNs and Ce-DMBGNs exhibited high bioactivity as evidenced by the rapid formation of hydroxyapatite (HA) after immersion in simulated body fluid (SBF) for 7 days. In addition, DMBGNs and Ce-DMBGNs showed high propolis loading efficiency and sustained release behavior. The results suggest that the developed Ce-DMBGNs have the potential to be used as a delivery vehicle of therapeutic ions and drugs in bone regeneration applications. |
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