Upconversion nanohybrids for NIR-induced photorepair of DNA etheno adducts

[EN] Here, we report NIR-triggered photorepair of DNA damages via photosensitization by using well-known upconversion nanohybrids consisting of ytterbium and erbium co-doped core-shell upconversion nanoparticles (UCs) and Rose Bengal (UC@RB). Specifically, two purine-derived etheno adducts (1,N6-eth...

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Detalles Bibliográficos
Autores: Francés-Soriano, Laura|||0000-0002-5630-4199, Rodríguez Muñiz, Gemma María|||0000-0001-8989-2401, Lhiaubet, Virginie Lyria|||0000-0002-8205-8892, Lizondo-Aranda, Paloma, Bellezza, Delia, González-Béjar, Maria
Tipo de recurso: artículo
Fecha de publicación:2025
País:España
Institución:Universitat Politècnica de València (UPV)
Repositorio:RiuNet. Repositorio Institucional de la Universitat Politécnica de Valéncia
Idioma:inglés
OAI Identifier:oai:riunet.upv.es:10251/224390
Acceso en línea:https://riunet.upv.es/handle/10251/224390
Access Level:acceso abierto
Palabra clave:Nanohybrids
Photosensitization
DNA damages
Descripción
Sumario:[EN] Here, we report NIR-triggered photorepair of DNA damages via photosensitization by using well-known upconversion nanohybrids consisting of ytterbium and erbium co-doped core-shell upconversion nanoparticles (UCs) and Rose Bengal (UC@RB). Specifically, two purine-derived etheno adducts (1,N6-etheno-2 '-deoxyadenosine (epsilon dA) and 1,N2-etheno-2 '-deoxyguanosine (epsilon dG)) have been used as proof of concept.

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